{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T11:13:32Z","timestamp":1791026012942,"version":"4.1.0"},"reference-count":32,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,2,13]],"date-time":"2024-02-13T00:00:00Z","timestamp":1707782400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Brugada syndrome (BrS) is characterized by ST\u2010segment elevation in the right precordial leads, which is not explained by ischemia, electrolyte disturbances, or obvious structural heart disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>In present study, we aim to evaluate presentation, long\u2010term outcome, genetic findings, and therapeutic interventions in patients with BrS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Between September 2001 and June 2022, all consecutive patients with diagnosis of BrS were enrolled in the present study. All patients gave written informed consent for the procedure, and the local ethical committee approved the study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 76 cases, 79% were proband and 21% were detected during screening after diagnosis of BrS in a family member. Thirty\u2010three (43%) patients had a typical spontaneous electrocardiogram (ECG) pattern. Thirty percent of the patients were symptomatic; symptomatic patients were more likely to have spontaneous type 1 Brugada ECG pattern in their ECGs (<jats:italic>p<\/jats:italic>\u2009=\u2009.01), longer PR interval (<jats:italic>p<\/jats:italic> = .03), and SCN5A mutation (<jats:italic>p<\/jats:italic>\u2009=\u2009.01) than asymptomatic patients. The mean PR interval was considerably longer in men than women (<jats:italic>p<\/jats:italic>\u2009=\u2009.034). <jats:italic>SCN5A<\/jats:italic> mutation was found in 9 out of 50 (18%) studied patients. Fifteen percent received appropriate implantable cardioverter\u2010defibrillator (ICD) therapy and inappropriate ICD interventions were observed in 17%. Presentation with aborted SCD or arrhythmic syncope was the only predictor of adverse outcome in follow\u2010up (odds ratio: 3.1, 95% confidence interval: 0.7\u201319.6, <jats:italic>p<\/jats:italic>\u2009=\u2009.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Symptomatic patients with BrS are more likely to present with spontaneous type 1 Brugada ECG pattern, longer PR interval, and pathogenic mutation in SCN5A gene. Appropriate ICD interventions are more likely in symptomatic patients and those with <jats:italic>SCN5A<\/jats:italic> mutation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jce.16206","type":"journal-article","created":{"date-parts":[[2024,2,13]],"date-time":"2024-02-13T09:14:06Z","timestamp":1707815646000},"page":"708-714","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Brugada syndrome in Iran: Insights from a 12\u2010year longitudinal study"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9963-6628","authenticated-orcid":false,"given":"Majid","family":"Haghjoo","sequence":"first","affiliation":[{"name":"Cardiac Electrophysiology Research Center, Rajaie Cardiovascular Medical and Research Institute Iran University of Medical Sciences Tehran Iran"},{"name":"Department of Cardiac Electrophysiology, Rajaie Cardiovascular Medical and Research Institute Iran University of Medical 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