{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T11:25:48Z","timestamp":1787311548086,"version":"build-2736575974"},"reference-count":25,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,3,13]],"date-time":"2024-03-13T00:00:00Z","timestamp":1710288000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100001316","name":"Abbott Laboratories","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001316","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006510","name":"Duke University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006510","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Peak frequency (PF) mapping is a novel method that may identify critical portions of myocardial substrate supporting reentry. The aim of this study was to describe and evaluate PF\u00a0mapping combined with omnipolar voltage mapping in the identification of critical isthmuses of left atrial (LA) atypical flutters.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and Results<\/jats:title>\n                    <jats:p>\n                      LA omnipolar voltage and PF maps were generated in flutter using the Advisor HD\u2010Grid catheter (Abbott) and EnSite Precision Mapping System (Abbott) in 12 patients. Normal voltage was defined as \u22650.5\u2009mV, low\u2010voltage as 0.1\u22120.5\u2009mV, and scar as &lt;0.1\u2009mV. PF distributions were compared with ANOVA and post hoc Tukey analyses. The 1\u2009cm radius from arrhythmia termination was compared to global myocardium with unpaired\n                      <jats:italic>t<\/jats:italic>\n                      \u2010testing. The mean age was 65.8\u2009\u00b1\u20099.7 years and 50% of patients were female. Overall, 34\u2009312 points were analyzed. Atypical flutters most frequently involved the mitral isthmus (58%) or anterior wall (25%). Mean PF varied significantly by myocardial voltage: normal (335.5\u2009\u00b1\u2009115.0\u2009Hz), low (274.6\u2009\u00b1\u2009144.0\u2009Hz), and scar (71.6\u2009\u00b1\u2009140.5\u2009Hz) (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.0001 for all pairwise comparisons). All termination sites resided in low\u2010voltage regions containing intermediate or high PF. Overall, mean voltage in the 1\u2009cm radius from termination was significantly lower than the remaining myocardium (0.58\u00a0vs. 0.95\u2009mV,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.0001) and PF was significantly higher (326.4\u00a0vs. 245.1\u2009Hz,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.0001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Low\u2010voltage, high\u2010PF areas may be critical targets during catheter ablation of atypical atrial flutter.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jce.16221","type":"journal-article","created":{"date-parts":[[2024,3,13]],"date-time":"2024-03-13T05:29:05Z","timestamp":1710307745000},"page":"950-964","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Peak frequency mapping of atypical atrial flutter"],"prefix":"10.1111","volume":"35","author":[{"given":"Maham F.","family":"Karatela","sequence":"first","affiliation":[{"name":"Cardiac Electrophysiology Section, Division of Cardiology Duke University Medical Center Durham North Carolina USA"},{"name":"Duke Clinical Research Institute Durham North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert S.","family":"Dowell","sequence":"additional","affiliation":[{"name":"Cardiac Electrophysiology Section, Division of Cardiology Duke University Medical Center Durham North Carolina USA"},{"name":"Abbott St. Paul Minnesota 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