{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T16:41:08Z","timestamp":1774629668391,"version":"3.50.1"},"reference-count":26,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,3,13]],"date-time":"2024-03-13T00:00:00Z","timestamp":1710288000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Repolarization dispersion in the right ventricular outflow tract (RVOT) contributes to the type\u20101 electrocardiographic (ECG) phenotype of Brugada syndrome (BrS), while data on the significance and feasibility of mapping repolarization dispersion in BrS patients are scarce. Moreover, the role of endocardial repolarization dispersion in BrS is poorly investigated. We aimed to assess endocardial repolarization patterns through an automated calculation of activation recovery interval (ARI) estimated on unipolar electrograms (UEGs) in spontaneous type\u20101 BrS patients and controls; we also investigated the relation between ARI and right ventricle activation time (RVAT), and T\u2010wave peak\u2010to\u2010end interval (Tpe) in BrS patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients underwent endocardial high\u2010density electroanatomical mapping (HDEAM); BrS showing an overt type\u20101 ECG were defined as\u00a0OType1, while those without (latent type\u20101 ECG\u00a0and\u00a0LType1) received ajmaline infusion. BrS patients only underwent programmed ventricular stimulation (PVS). Data were elaborated to obtain ARI corrected with the Bazett formula (ARIc), while RVAT was derived from activation maps.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>39 BrS subjects (24 OType1 and 15 LTtype1) and 4 controls were enrolled. OType1 and post\u2010ajmaline LType1 showed longer mean ARIc than controls (306\u2009\u00b1\u200927.3\u2009ms and 333.3\u2009\u00b1\u200916.3\u2009ms vs. 281.7\u2009\u00b1\u200910.3 ms, <jats:italic>p<\/jats:italic>\u2009=\u2009.05 and <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001, respectively). Ajmaline induced a significant prolongation of ARIc compared to pre\u2010ajmaline LTtype1 (333.3\u2009\u00b1\u200916.3\u2009vs. 303.4\u2009\u00b1\u200920.7\u2009ms, <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001) and OType1 (306\u2009\u00b1\u200927.3\u2009ms, <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001). In patients with type\u20101 ECG (OTtype1 and post\u2010ajmaline LType1) ARIc correlated with RVAT (<jats:italic>r<\/jats:italic>\u2009=\u2009.34, <jats:italic>p<\/jats:italic>\u2009=\u2009.04) and Tpec (<jats:italic>r<\/jats:italic>\u2009=\u2009.60, <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001), especially in OType1 subjects (<jats:italic>r<\/jats:italic>\u2009=\u2009.55, <jats:italic>p<\/jats:italic>\u2009=\u2009.008 and <jats:italic>r<\/jats:italic>\u2009=\u2009.65 <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001, respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>ARIc mapping demonstrates increased endocardial repolarization dispersion in RVOT in BrS. Endocardial ARIc positively correlates with RVAT and Tpec, especially in OType1.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jce.16244","type":"journal-article","created":{"date-parts":[[2024,3,13]],"date-time":"2024-03-13T09:55:34Z","timestamp":1710323734000},"page":"965-974","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Endocardial repolarization dispersion in BrS: A novel automatic algorithm for mapping activation recovery interval"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-3514-8774","authenticated-orcid":false,"given":"Sara","family":"Latrofa","sequence":"first","affiliation":[{"name":"Health Science Interdisciplinary Center Scuola Superiore Sant'Anna Pisa Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valentina","family":"Hartwig","sequence":"additional","affiliation":[{"name":"Institute of Clinical Physiology Pisa Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lorenzo","family":"Bachi","sequence":"additional","affiliation":[{"name":"Health Science Interdisciplinary Center Scuola Superiore Sant'Anna Pisa Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pasquale","family":"Notarstefano","sequence":"additional","affiliation":[{"name":"Cardiovascular and Neurological Department San Donato Hospital Arezzo Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvia","family":"Garibaldi","sequence":"additional","affiliation":[{"name":"Fondazione Toscana Gabriele Monasterio Pisa Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luca","family":"Panchetti","sequence":"additional","affiliation":[{"name":"Fondazione Toscana Gabriele Monasterio Pisa Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martina","family":"Nesti","sequence":"additional","affiliation":[{"name":"Fondazione Toscana Gabriele Monasterio Pisa Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5965-6539","authenticated-orcid":false,"given":"Paolo","family":"Seghetti","sequence":"additional","affiliation":[{"name":"Health Science Interdisciplinary Center Scuola Superiore Sant'Anna Pisa Italy"},{"name":"Institute of Clinical Physiology Pisa Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Umberto","family":"Startari","sequence":"additional","affiliation":[{"name":"Fondazione Toscana Gabriele Monasterio Pisa Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gianluca","family":"Mirizzi","sequence":"additional","affiliation":[{"name":"Fondazione Toscana Gabriele Monasterio Pisa Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Sole","family":"Morelli","sequence":"additional","affiliation":[{"name":"Fondazione Toscana Gabriele Monasterio Pisa Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0555-542X","authenticated-orcid":false,"given":"Martina","family":"Modena","sequence":"additional","affiliation":[{"name":"Health Science Interdisciplinary Center Scuola Superiore Sant'Anna Pisa Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Mazzanti","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine University of Pavia Pavia Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michele","family":"Emdin","sequence":"additional","affiliation":[{"name":"Health Science Interdisciplinary Center Scuola Superiore Sant'Anna Pisa Italy"},{"name":"Fondazione Toscana Gabriele Monasterio Pisa Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alberto","family":"Giannoni","sequence":"additional","affiliation":[{"name":"Health Science Interdisciplinary Center Scuola Superiore Sant'Anna Pisa Italy"},{"name":"Fondazione Toscana Gabriele Monasterio Pisa Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Rossi","sequence":"additional","affiliation":[{"name":"Fondazione Toscana Gabriele Monasterio Pisa Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,3,13]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(92)90253-J"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardiores.2005.03.005"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000118467.53182.D1"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1540-8167.2001.01369.x"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/joa3.12118"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(81)91028-6"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehab724.0638"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2016.07.025"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2007.10.059"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.108.771401"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.117.005107"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2013.05.014"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehac262"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.115.017885"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/jce.14155"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2021.646023"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-012387582-2\/50038-1"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2019.01.017"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.100.15.1660"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2006.05.027"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00034.2011"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.110.972612"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2014.01.067"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.117.005775"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2015.07.029"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2011.08.064"}],"container-title":["Journal of Cardiovascular Electrophysiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jce.16244","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,25]],"date-time":"2024-04-25T11:08:54Z","timestamp":1714043334000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jce.16244"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3,13]]},"references-count":26,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2024,5]]}},"alternative-id":["10.1111\/jce.16244"],"URL":"https:\/\/doi.org\/10.1111\/jce.16244","archive":["Portico"],"relation":{},"ISSN":["1045-3873","1540-8167"],"issn-type":[{"value":"1045-3873","type":"print"},{"value":"1540-8167","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,3,13]]},"assertion":[{"value":"2023-12-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-02-27","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-03-13","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}