{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T17:43:56Z","timestamp":1791395036963,"version":"4.3.3"},"reference-count":16,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,3,19]],"date-time":"2024-03-19T00:00:00Z","timestamp":1710806400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>The relationships between baseline tissue local impedance (LI), contact force (CF), atrial fibrosis, and atrial rhythm are uninvestigated in a clinical setting. We compared the relationship of LI and CF between atrial fibrillation (AF) and sinus rhythm (SR) accounting for the effects of atrial fibrosis as assessed by bipolar voltage and LI.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients undergoing persistent AF ablation were recruited. LI was recorded referenced to patient blood pool\u00a0(LIr) and concurrent to changes in CF, with data collected at the same locations in AF and SR.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty patients were recruited. 109 locations were sampled obtaining 1903 data points (SR: 966, AF: 937). CF correlated strongly with LI (repeated measures correlation\u2009=\u20090.64). The relationship between CF and LIr was logarithmic. Rhythm and CF had a significant main (both <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.0005) and interaction effect (<jats:italic>p<\/jats:italic>\u2009=\u2009.022) on tissue LI: AF demonstrated higher LIr values than SR for similar CF. Bipolar voltage had no effect on the relationship of CF to LIr in either rhythm. Assessing fibrosis using LIr showed an interaction effect with CF for LIr in SR and AF, (SR: <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.0005, AF: <jats:italic>p<\/jats:italic>\u2009=\u2009.01), with increased fibrosis showing lesser change in LIr per gram of CF.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>CF and rhythm significantly affect the measured LIr of LA myocardium. Optimal catheter\u2010tissue coupling may be better achieved with higher levels of CF and in AF rather than SR. Atrial fibrosis, as assessed by LIr\u00a0but not bipolar voltage, affected the CF\u2013LI relationship.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jce.16253","type":"journal-article","created":{"date-parts":[[2024,3,19]],"date-time":"2024-03-19T11:19:55Z","timestamp":1710847195000},"page":"1061-1068","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Determinants of left atrial local impedance: Relationships with contact force, atrial fibrosis, and rhythm"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5517-1964","authenticated-orcid":false,"given":"Alexander P.","family":"Bates","sequence":"first","affiliation":[{"name":"Department of Cardiology University Hospital Southampton NHS Foundation Trust Tremona Road Southampton UK"},{"name":"School of Human Development and Health, Faculty of Medicine University of Southampton Southampton UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Paisey","sequence":"additional","affiliation":[{"name":"Department of Cardiology University Hospital Southampton NHS Foundation Trust Tremona Road Southampton UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arthur","family":"Yue","sequence":"additional","affiliation":[{"name":"Department of Cardiology University Hospital Southampton NHS Foundation Trust Tremona Road Southampton UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phil","family":"Banks","sequence":"additional","affiliation":[{"name":"Department of Cardiology University Hospital Southampton NHS Foundation Trust Tremona Road Southampton UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1174-6401","authenticated-orcid":false,"given":"Paul R.","family":"Roberts","sequence":"additional","affiliation":[{"name":"Department of Cardiology University Hospital Southampton NHS Foundation Trust Tremona Road Southampton UK"},{"name":"School of Human Development and Health, Faculty of Medicine University of Southampton Southampton UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Waqas","family":"Ullah","sequence":"additional","affiliation":[{"name":"Department of Cardiology University Hospital Southampton NHS Foundation Trust Tremona Road Southampton UK"},{"name":"School of Human Development and Health, Faculty of Medicine University of Southampton Southampton UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,3,19]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2020.03.016"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/jce.15356"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/jce.15135"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/euab004"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacep.2022.01.009"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10840-022-01317-7"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/pace.14500"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.117.005831"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2021.788885"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/jce.12542"},{"key":"e_1_2_8_12_1","first-page":"31","article-title":"Redefining atrial scar: an analysis using pacing thresholds, electrogram amplitudes and local impedance. Can we improve on 0.05 and 0.5mV?","volume":"8","author":"Bates AP","year":"2022","journal-title":"Eur\u00a0J\u00a0Arrhythm\u00a0Electrophysiol"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1109\/TBME.2022.3196545"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/jce.15253"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2021.808541"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10840-022-01282-1"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrcr.2020.11.004"}],"container-title":["Journal of Cardiovascular Electrophysiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jce.16253","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,9]],"date-time":"2024-07-09T04:33:06Z","timestamp":1720499586000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jce.16253"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3,19]]},"references-count":16,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2024,6]]}},"alternative-id":["10.1111\/jce.16253"],"URL":"https:\/\/doi.org\/10.1111\/jce.16253","archive":["Portico"],"relation":{},"ISSN":["1045-3873","1540-8167"],"issn-type":[{"value":"1045-3873","type":"print"},{"value":"1540-8167","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,3,19]]},"assertion":[{"value":"2022-12-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-03-07","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-03-19","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}