{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T23:36:09Z","timestamp":1793144169713,"version":"4.5.0"},"reference-count":25,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2024,5,17]],"date-time":"2024-05-17T00:00:00Z","timestamp":1715904000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100001316","name":"Abbott Laboratories","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001316","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Left bundle branch area (LBBA) pacing (LBBAP) has been proposed as an alternative therapy option in patients indicated for cardiac pacing to treat bradycardia or heart failure. The aim of the study was to evaluate the safety and effectiveness of LBBAP in patients implanted with a Tendril 2088 stylet\u2010driven lead.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The international retrospective data collection registry included 11 sites from 5 countries globally. Patients with attempted implants of the Tendril lead in the LBBA were followed for at least 6 months post the implant attempt. The primary safety and efficacy endpoints were freedom from LBBAP lead\u2010related serious adverse events and the composite of LBBA capture threshold of \u22642.0\u2009V and R\u2010wave amplitudes \u22655\u2009mV (or \u2265value at implant), respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 221 patients with attempted implants of the Tendril 2088 lead in the LBBA, 91.4% (202\/221) had successful implants for LBBAP. Regardless of the LBBAP implant success, all patients were followed for at least 6 months (8.7\u2009\u00b1\u20097.3 months). Baseline characteristics: 44% female, 84% \u226565 years old, 34% coronary artery disease, and 86% of primary indications for pacemaker implant. Both primary safety and effectiveness endpoints were met (freedom from LBBAP lead\u2010related serious adverse device effects of 99.5% and electrical performance composite success rate of 93%). The capture thresholds in LBBAP at implant and 6 months were 0.8\u2009\u00b1\u20090.3\u2009V@0.4\u2009\u00b1\u20090.1\u2009ms and 0.8\u2009\u00b1\u20090.3\u2009V@0.4\u2009\u00b1\u20090.1\u2009ms. The rate of patients with capture threshold rise \u22651\u2009V was 1.5% through 6 months. The R\u2010wave amplitudes in LBBAP at implant and 6 months were 9.3\u2009\u00b1\u20093.2\u2009mV and 10.6\u2009\u00b1\u20093.0\u2009mV.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This large multicenter study demonstrates that the stylet\u2010driven Tendril\u2122\u00a0STS 2088 lead is safe and effective for LBBAP with high success and low complication rates.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jce.16274","type":"journal-article","created":{"date-parts":[[2024,5,17]],"date-time":"2024-05-17T12:23:22Z","timestamp":1715948602000},"page":"1452-1460","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Result of the left bundle branch area pacing data collection registry, an international multicenter study of conduction system pacing with a Tendril STS 2088 stylet\u2010driven lead"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2230-100X","authenticated-orcid":false,"given":"Pugazhendhi","family":"Vijayaraman","sequence":"first","affiliation":[{"name":"Geisinger Wyoming Valley Medical Center Geisinger Heart Institute Wilkes\u2010Barre Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Foo","sequence":"additional","affiliation":[{"name":"Tan Tock Seng Hospital Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tien Siang Eric","family":"Lim","sequence":"additional","affiliation":[{"name":"National Heart Centre Singapore Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evangelos","family":"Diamantakos","sequence":"additional","affiliation":[{"name":"Eisenhower Medical Center Rancho Mirage California 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