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Our review specifically targets Hispanic\/Latino and Indigenous populations, which are often underrepresented in healthcare studies. This review encompasses investigations into genetic variants, epidemiology, etiologies, and clinical risk factors associated with arrhythmias in these demographic groups. The review explores the Hispanic paradox, a phenomenon linking healthcare outcomes to socioeconomic factors within Hispanic communities in the United States. Furthermore, it discusses studies exemplifying this observation in the context of arrhythmias and ion channelopathies in Hispanic populations. Current research also sheds light on disparities in overall healthcare quality in Indigenous populations. The available yet limited literature underscores the pressing need for more extensive and comprehensive research on cardiac ion channelopathies in Hispanic\/Latino and Indigenous populations. Specifically, additional studies are essential to fully characterize pathogenic genetic variants, identify population\u2010specific risk factors, and address health disparities to enhance the detection, prevention, and management of arrhythmias and sudden cardiac death in these demographic groups.<\/jats:p>","DOI":"10.1111\/jce.16282","type":"journal-article","created":{"date-parts":[[2024,4,24]],"date-time":"2024-04-24T03:23:07Z","timestamp":1713928987000},"page":"1219-1228","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Arrhythmias and ion channelopathies causing sudden cardiac death in Hispanic\/Latino and Indigenous populations"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0116-8297","authenticated-orcid":false,"given":"Sahil","family":"Zaveri","sequence":"first","affiliation":[{"name":"Cardiovascular Research Program VA New York Harbor Healthcare System New York New 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