{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T15:20:24Z","timestamp":1778858424282,"version":"3.51.4"},"reference-count":69,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2024,4,25]],"date-time":"2024-04-25T00:00:00Z","timestamp":1714003200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Although left bundle branch area pacing (LBBAP) has been shown to be a feasible option for delivering physiological pacing, data are largely limited to single\u2010center reports. The aim of this analysis was to systematically assess the safety and efficacy of LBBAP with the Model 3830 lead among primarily bradycardia patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and Results<\/jats:title><jats:p>PubMed, Embase, Cochrane Library, and Google Scholar were searched for full\u2010text articles on LBBAP using the SelectSecure Model 3830 lumenless lead. Rates and means were estimated using random\u2010 and mixed\u2010effects models. Of 3395 articles, 53 met inclusion criteria, representing 6061 patients undergoing an implant attempt. Average patient age was 68.1 years (95% CI: 66.6, 69.6) and 53.1% were male (95% CI: 50.5%, 55.7%). The average implant success rate among bradycardia\u2010indicated patients was 92.7% (95% CI: 89.5%, 94.9%). The overall estimated procedural adverse event rate was 2.5% (95% CI: 1.1%, 5.4%). The estimated septal perforation rate at implant was 1.6% (95% CI: 1.0%, 2.6%) with no adverse clinical sequelae reported. Pacing thresholds were low at implant (0.67\u2009V [95% CI: 0.64, 0.70]) and remained stable through 12 months (0.76\u2009V [95% CI: 0.72, 0.80]). Among bradycardia\u2010indicated patients, LVEF remained stable from baseline to post\u2010implant (59.5% [95% CI: 57.9%, 61.1%] vs. 60.1% [95% CI: 58.5%, 61.7%]).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This meta\u2010analysis including 6061 patients implanted with a Model 3830 lead for LBBAP found an average implant success rate of 92.7% and a procedural adverse event rate of 2.5% with stable electrical parameters and LVEF post\u2010implant.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jce.16287","type":"journal-article","created":{"date-parts":[[2024,4,26]],"date-time":"2024-04-26T04:24:22Z","timestamp":1714105462000},"page":"1721-1735","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Left bundle branch area pacing using a lumenless lead: A systematic literature review and meta\u2010analysis"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8527-569X","authenticated-orcid":false,"given":"Kenneth A.","family":"Ellenbogen","sequence":"first","affiliation":[{"name":"Department of Cardiac Electrophysiology Virginia Commonwealth University Health System Richmond Virginia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1430-4588","authenticated-orcid":false,"given":"Dedra H.","family":"Fagan","sequence":"additional","affiliation":[{"name":"Medtronic, Inc. 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