{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T05:33:23Z","timestamp":1772516003658,"version":"3.50.1"},"reference-count":5,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2024,5,9]],"date-time":"2024-05-09T00:00:00Z","timestamp":1715212800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>We performed a cross\u2010sectional study using the Centers for Disease Control and Prevention's (CDC's) Wide\u2010Ranging Online Data for Epidemiologic Research (WONDER) database to analyze the trends in cardiac implantable electronic device (CIED) infection\u2010related mortality from 1999 to 2020.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We analyzed the death certificate data from the CDC WONDER database from 1999 to 2020 for CIED infections in the US population aged \u226525 years using\u00a0International Classification of Diseases, Tenth Revision\u00a0(ICD\u201010) codes, listed as the underlying or contributing cause of death. Age\u2010adjusted mortality rates (AAMR) and 95% confidence intervals (CIs) were computed per 1 million population by standardizing crude mortality rates to the 2000 US census population. To assess annual mortality trends, we employed the Joinpoint regression model, calculating the annual percent change (APC) in AAMR and corresponding 95% CIs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Overall, there was an observed declining trend in AAMRs related to CIED infection\u2010related mortality. Males accounted for 55% of the total deaths, with persistently higher AAMRs compared to females over the study duration. Both males and females had an overall decreasing trend in AAMRs throughout the study duration. On race\/ethnicity stratified analysis, non\u2010Hispanic (NH) Blacks exhibited the highest overall AAMR, followed by NH American Indians or Alaska Natives, NH Whites, Hispanic or Latinos, and NH Asian or Pacific Islanders. On a stratified analysis based on region, the South region had the highest overall AAMR, followed by the Midwest, West, and Northeast regions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our study demonstrates a significant decline in CIED infection\u2010related mortality in patients over the last two decades. Notable gender, racial\/ethnic, and regional differences exist in the rates of mortality related to CIED infections.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jce.16298","type":"journal-article","created":{"date-parts":[[2024,5,10]],"date-time":"2024-05-10T05:19:25Z","timestamp":1715318365000},"page":"1487-1489","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Trends and disparities in cardiac implantable electronic device infection\u2010related mortality in the United States"],"prefix":"10.1111","volume":"35","author":[{"given":"Siddharth","family":"Agarwal","sequence":"first","affiliation":[{"name":"Department of Medicine University of Oklahoma Health Sciences Center Oklahoma City Oklahoma USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Usama","family":"Qamar","sequence":"additional","affiliation":[{"name":"Department of Medicine King Edward Medical University Lahore Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muhammad Bilal","family":"Munir","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine University of California Davis Sacramento California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zain Ul Abideen","family":"Asad","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Oklahoma Health Sciences Center Oklahoma City Oklahoma USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9560-1102","authenticated-orcid":false,"given":"Abhishek","family":"Deshmukh","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Mayo Clinic Rochester Minnesota USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel C.","family":"DeSimone","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Mayo Clinic Rochester Minnesota USA"},{"name":"Division of Infectious Diseases, Department of Internal Medicine Mayo Clinic Rochester Minnesota USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8420-4670","authenticated-orcid":false,"given":"Christopher V.","family":"DeSimone","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Mayo Clinic Rochester Minnesota USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,5,9]]},"reference":[{"key":"e_1_2_3_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacep.2019.06.016"},{"key":"e_1_2_3_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dku383"},{"key":"e_1_2_3_4_1","unstructured":"Centers for Disease Control and Prevention National Center for Health Statistics. Multiple cause of death 1999\u20102019 on CDC WONDER online database released in 2020. Data are from the multiple cause of death files 1999\u20102019 as compiled from data provided by the 57 vital statistics jurisdictions through the Vital Statistics Cooperative Program. Accessed December 26 2023.http:\/\/wonder.cdc.gov.webproxy2.ouhsc.edu\/mcd-icd10.html"},{"key":"e_1_2_3_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2021.12.023"},{"key":"e_1_2_3_6_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.122.025600"}],"container-title":["Journal of Cardiovascular Electrophysiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jce.16298","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,11]],"date-time":"2024-07-11T14:57:45Z","timestamp":1720709865000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jce.16298"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,9]]},"references-count":5,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2024,7]]}},"alternative-id":["10.1111\/jce.16298"],"URL":"https:\/\/doi.org\/10.1111\/jce.16298","archive":["Portico"],"relation":{},"ISSN":["1045-3873","1540-8167"],"issn-type":[{"value":"1045-3873","type":"print"},{"value":"1540-8167","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,5,9]]},"assertion":[{"value":"2024-03-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-04-28","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-05-09","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}