{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T18:12:54Z","timestamp":1781115174379,"version":"3.54.1"},"reference-count":31,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2024,5,16]],"date-time":"2024-05-16T00:00:00Z","timestamp":1715817600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004374","name":"Medtronic","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004374","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Cryoballoon ablation is a safe and efficient rhythm control strategy in atrial fibrillation (AF) patients. The impact of time from diagnosis to ablation is unclear. The aim of this study was to examine the impact of timing of first\u2010time cryoballoon ablation on AF recurrence in a nationwide cohort of AF patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and Results<\/jats:title><jats:p>From nationwide registers, all AF patients \u226518 years of age who underwent first\u2010time AF cryoballoon ablation in Denmark from 2012 to 2018 were included. The AF patients were stratified by ablation timing: Early group (\u22641 year after AF diagnosis), intermediate group (1\u20133 years after AF diagnosis), and late group (\u22653 years after AF diagnosis). By adjusted Cox regression models, the effect of timing on AF recurrence was examined.<\/jats:p><jats:p>This study included 1064 AF patients with a median age of 63 years. Most patients were male (66%) and had paroxysmal AF (67%). The 1\u2010year risk of AF recurrence increased from 31% in the early group to 41% and 44% in the intermediate and late group. The hazard ratios (95% confidence intervals) were 1.28 (0.95, 1.74) in the intermediate group and 1.42 (1.09, 1.86) in the late group when compared to the early group. Continuous diagnosis\u2010to\u2010ablation time seemed to have the greatest impact on AF recurrence within the first 2 years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In AF patients undergoing cryoballoon ablation, late timing of ablation was associated with a significantly higher AF recurrence rate when compared to early timing of ablation. These findings support early cryoballoon ablation to improve the outcomes after ablation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jce.16303","type":"journal-article","created":{"date-parts":[[2024,5,17]],"date-time":"2024-05-17T03:34:07Z","timestamp":1715916847000},"page":"1429-1439","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Effect of early cryoballoon ablation on atrial fibrillation recurrence\u2014A Danish nationwide register study"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-0928-5547","authenticated-orcid":false,"given":"Regitze","family":"Hein","sequence":"first","affiliation":[{"name":"Copenhagen Cardiovascular Research Center, Department of Cardiology Copenhagen University Hospital Herlev and Gentofte Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lise Da","family":"Riis\u2010Vestergaard","sequence":"additional","affiliation":[{"name":"Copenhagen Cardiovascular Research Center, Department of Cardiology Copenhagen University Hospital Herlev and Gentofte Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacob","family":"T\u00f8nnesen","sequence":"additional","affiliation":[{"name":"Copenhagen Cardiovascular Research Center, Department of Cardiology Copenhagen University Hospital Herlev and Gentofte Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher Ryan","family":"Zo\u0308rner","sequence":"additional","affiliation":[{"name":"Copenhagen Cardiovascular Research Center, Department of Cardiology Copenhagen University Hospital Herlev and Gentofte Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter Vibe","family":"Rasmussen","sequence":"additional","affiliation":[{"name":"Copenhagen Cardiovascular Research Center, Department of Cardiology Copenhagen University Hospital Herlev and Gentofte Copenhagen Denmark"},{"name":"The Department of Cardiology Copenhagen University Hospital Bispebjerg and Frederiksberg Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1541-309X","authenticated-orcid":false,"given":"Martin Huth","family":"Ruwald","sequence":"additional","affiliation":[{"name":"Copenhagen Cardiovascular Research Center, Department of Cardiology Copenhagen University Hospital Herlev and Gentofte Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arne","family":"Johannessen","sequence":"additional","affiliation":[{"name":"Copenhagen Cardiovascular Research Center, Department of Cardiology Copenhagen University Hospital Herlev and Gentofte Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ren\u00e9 Husted","family":"Worck","sequence":"additional","affiliation":[{"name":"Copenhagen Cardiovascular Research Center, Department of Cardiology Copenhagen University Hospital Herlev and Gentofte Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jim","family":"Hansen","sequence":"additional","affiliation":[{"name":"Copenhagen Cardiovascular Research Center, Department of Cardiology Copenhagen University Hospital Herlev and Gentofte Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte","family":"Middelfart","sequence":"additional","affiliation":[{"name":"Copenhagen Cardiovascular Research Center, Department of Cardiology Copenhagen University Hospital Herlev and Gentofte Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gunnar Hilmar","family":"Gislason","sequence":"additional","affiliation":[{"name":"Copenhagen Cardiovascular Research Center, Department of Cardiology Copenhagen University Hospital Herlev and Gentofte Copenhagen Denmark"},{"name":"The Danish Heart Foundation Copenhagen Denmark"},{"name":"Department of Clinical Medicine, Faculty of Health and Medical Sciences University of Copenhagen Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morten Lock","family":"Hansen","sequence":"additional","affiliation":[{"name":"Copenhagen Cardiovascular Research Center, Department of Cardiology Copenhagen University Hospital Herlev and Gentofte Copenhagen Denmark"},{"name":"Department of Clinical Medicine, Faculty of Health and Medical Sciences University of Copenhagen Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,5,16]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2017.01.038"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2009.11.040"},{"key":"e_1_2_9_4_1","unstructured":"ESC Guidelines on atrial fibrillation. 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