{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T11:26:02Z","timestamp":1740137162813,"version":"3.37.3"},"reference-count":18,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2024,5,16]],"date-time":"2024-05-16T00:00:00Z","timestamp":1715817600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U1913210"],"award-info":[{"award-number":["U1913210"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>The accuracy of surface ECG algorithms for predicting the origin of outflow tract ventricular arrhythmias (OT\u2010VAs) might be questioned. Intracardiac electrograms recorded at anatomic landmarks could provide new predictive insights. We aim to evaluate the efficacy of a novel criterion utilizing the activation pattern of the coronary sinus (CS) in localizing OT\u2010VAs, including VAs originating from the right ventricular outflow tract (RVOT), endocardial left ventricular outflow tract (Endo\u2010LVOT), and epicardial left ventricular outflow tract (Epi\u2010LVOT).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We measured the ventricular activation time of the mitral annulus (MA) from the onset of the earliest QRS complex of VAs to the initial deflection over the isoelectric line at local signals, namely the QRS\u2010MA interval. The activation at 3 and 12 o'clock of the MA was recorded as the QRS\u2010MA3 and QRS\u2010MA12 intervals, respectively. Their predictive values were compared to previous ECG algorithms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 68 patients with OT\u2010VAs were enrolled (51 for development and 17 for validation). From early to late, the ventricular activation sequences at MA12 were as follows: Epi\u2010LVOT, Endo\u2010LVOT, and RVOT. In LBBB morphology OT\u2010VAs, the QRS\u2010MA12 interval was significantly earlier for LVOT origins than RVOT origins. In the combined cohort of development and validation cohort, a cut\u2010off value of \u226410\u2009ms predicted the LVOT origin with a sensitivity of 100% and specificity of 78%. The QRS\u2010MA12 interval\u2009\u2264\u2009\u221224\u2009ms additionally predicted epicardial LVOT sites of origin.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The QRS\u2010MA interval could accurately differentiate the OT\u2010VAs localization.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jce.16310","type":"journal-article","created":{"date-parts":[[2024,5,17]],"date-time":"2024-05-17T05:44:55Z","timestamp":1715924695000},"page":"1440-1449","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Activation pattern of the coronary sinus facilitates the differentiation for ventricular outflow tract arrhythmias"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0528-9870","authenticated-orcid":false,"given":"Li\u2010Jie","family":"Mi","sequence":"first","affiliation":[{"name":"State Key Laboratory of Cardiovascular Disease, Department of Cardiology Fuwai Hospital, National Center for Cardiovascular Disease, Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China"},{"name":"Department of Cardiology The First Affiliated Hospital, Zhejiang University School of Medicine Hangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2466-9046","authenticated-orcid":false,"given":"Si\u2010Xian","family":"Weng","sequence":"additional","affiliation":[{"name":"Department of Cardiology Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences Beijing China"},{"name":"College of Life Science University of Chinese Academy of Sciences Beijing China"},{"name":"Department of Cardiology Beijing Anzhen Hospital, Affiliated to Capital Medical University Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qi","family":"Sun","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Cardiovascular Disease, Department of Cardiology Fuwai Hospital, National Center for Cardiovascular Disease, Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9706-9239","authenticated-orcid":false,"given":"Hong\u2010Da","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Cardiovascular Disease, Department of Cardiology Fuwai Hospital, National Center for Cardiovascular Disease, Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lei","family":"Ding","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Cardiovascular Disease, Department of Cardiology Fuwai Hospital, National Center for Cardiovascular Disease, Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 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