{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T16:11:18Z","timestamp":1791821478169,"version":"4.3.4"},"reference-count":29,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2024,6,18]],"date-time":"2024-06-18T00:00:00Z","timestamp":1718668800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>The impact of early recurrence of atrial tachyarrhythmia (ERAT) within the 90\u2010day blanking period on long\u2010term outcomes in atrial fibrillation (AF) patients undergoing cryoballoon ablation (CBA) is controversial. This study aimed to assess the relationship between ERAT and late recurrence of atrial tachyarrhythmia (LRAT) post\u2010CBA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Utilizing data from a multicenter registry in Korea (May 2018 to June 2022), we analyzed the presence and timing of ERAT (&lt;30, 30\u201360, and 60\u201390 days) and its association with LRAT risk after CBA. LRAT was defined as any recurrence of AF, atrial flutter, or atrial tachycardia lasting more than 30\u2009s beyond the 90 days.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Out of 2636 patients, 745 (28.2%) experienced ERAT post\u2010CBA. Over an average follow\u2010up period of 21.2\u2009\u00b1\u200910.3 months, LRAT was observed in 874 (33.1%) patients. Patients with ERAT had significantly lower 1\u2010year LRAT freedom compared to those without ERAT (42.6% vs. 85.5%, <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001). Multivariate analysis identified ERAT as a potential predictor of LRAT, with a hazard ratio (HR) of 3.98 (95% confidence interval [CI], 3.47\u20134.57). Significant associations were noted across all examined time frames (HR, 3.84; 95% CI, 3.32\u20134.45 in &lt;30 days, HR, 5.53; 95% CI, 4.13\u20137.42 in 30\u201360 days, and HR, 4.29; 95% CI, 3.12\u20135.89 in 60\u201390 days). This finding was consistently observed across all types of AF.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>ERAT during the 90\u2010day blanking period strongly predicts LRAT in AF patients undergoing CBA, indicating a need to reconsider the clinical significance of this period.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jce.16334","type":"journal-article","created":{"date-parts":[[2024,6,19]],"date-time":"2024-06-19T04:49:42Z","timestamp":1718772582000},"page":"1614-1623","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Long\u2010term clinical impact of early recurrence of atrial tachyarrhythmia after cryoballoon ablation in patients with atrial fibrillation"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8831-8344","authenticated-orcid":false,"given":"Jinsun","family":"Park","sequence":"first","affiliation":[{"name":"Division of Cardiology, Asan Medical Center University of Ulsan College of Medicine Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myung\u2010Jin","family":"Cha","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Asan Medical Center University of Ulsan College of Medicine Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8716-1146","authenticated-orcid":false,"given":"Chang Hee","family":"Kwon","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine Konkuk University Medical Center, Konkuk University School of Medicine Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9867-4991","authenticated-orcid":false,"given":"Min Soo","family":"Cho","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Asan Medical Center University of Ulsan College of Medicine 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Youn","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine, Heart Vascular Stroke Institute Samsung Medical Center, Sungkyunkwan University School of Medicine Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sung Ho","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine, Kangbuk Samsung Hospital Sungkyunkwan University School of Medicine Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junbeom","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Cardiology School of Medicine Ewha Womans University Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6599-6895","authenticated-orcid":false,"given":"Ki\u2010Hun","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of 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