{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T22:47:28Z","timestamp":1790722048066,"version":"4.1.0"},"reference-count":76,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2024,6,28]],"date-time":"2024-06-28T00:00:00Z","timestamp":1719532800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Gliflozins are recommended as first\u2010line treatment in patients with heart failure and\/or cardiovascular comorbidities and are demonstrated to reduce atrial fibrillation (AF) occurrence. However, it is not well known which gliflozin yields the larger cardioprotection in terms of AF occurrence reduction. Hence, we aimed to compare data regarding AF recurrence associated with different gliflozins.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>An accurate search of online scientific libraries (from inception to June 1, 2023) was performed. Fifty\u2010nine studies were included in the meta\u2010analysis involving 108\u2009026 patients, of whom 60\u2009097 received gliflozins and 47\u2009929 received placebo.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Gliflozins provided a statistically significant reduction of AF occurrence relative to standard of care therapy in the overall population (relative risks [RR]: 0.8880, 95% CI: [0.8059; 0.9784],\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.0164) and in patients with diabetes and cardiorenal diseases (RR: 0.8352, 95% CI: [0.7219; 0.9663],\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.0155). Dapagliflozin significantly decreased AF occurrence as compared to placebo (0.7259 [0.6337; 0.8316],\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.0001) in the overall population, in patients with diabetes (RR: 0.2482, 95% CI: [0.0682; 0.9033],\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.0345), with diabetes associated with cardiorenal diseases (RR: 0.7192, 95% CI: [0.5679; 0.9110],\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.0063) and in the subanalysis including studies with follow\u2010up \u22651 year (RR: 0.7792, 95% CI: [0.6508; 0.9330],\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.0066). No significant differences in terms of AF protection were found among different gliflozins.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Dapagliflozin use was associated with significant reduction in AF risk as compared to placebo in overall population and patients with diabetes, whereas the use of other gliflozins did not significantly reduce AF occurrence.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jce.16344","type":"journal-article","created":{"date-parts":[[2024,6,28]],"date-time":"2024-06-28T06:29:09Z","timestamp":1719556149000},"page":"1754-1765","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":46,"title":["SGLT2i effect on atrial fibrillation: A network meta\u2010analysis of randomized controlled 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Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-7621-5776","authenticated-orcid":false,"given":"Domenico","family":"Laviola","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular, Respiratory, Nephrological, Aenesthesiological and Geriatric Sciences \u201cSapienza\u201d University of Rome Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5995-4963","authenticated-orcid":false,"given":"Agostino","family":"Piro","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular, Respiratory, Nephrological, Aenesthesiological and Geriatric Sciences \u201cSapienza\u201d University of Rome Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"D'Amato","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular, Respiratory, Nephrological, Aenesthesiological and Geriatric Sciences 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