{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T19:34:51Z","timestamp":1790710491009,"version":"4.1.0"},"reference-count":17,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2024,6,25]],"date-time":"2024-06-25T00:00:00Z","timestamp":1719273600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Access site complications remain common following atrial fibrillation (AF) catheter ablation. Femoral vascular closure devices (VCDs) reduce time to hemostasis compared with manual compression, although large\u2010scale data comparing clinical outcomes between the two approaches are lacking.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Two cohorts of patients undergoing AF ablation were identified from 36 healthcare organizations using a global federated research network (TriNetX): those receiving a VCD for femoral hemostasis, and those not receiving a VCD. A 1:1 propensity score matching (PSM) model based on baseline characteristics was used to create two comparable cohorts. The primary outcome was a composite of all\u2010cause mortality, vascular complications, bleeding events, and need for blood transfusion. Outcomes were assessed during early (within 7 days of ablation) and extended follow\u2010up (within 8\u201330 days of ablation).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>After PSM, 28\u2009872 patients were included (14\u2009436 in each cohort). The primary composite outcome occurred less frequently in the VCD cohort during early (1.97% vs. 2.60%, odds ratio (OR) 0.76, 95% confidence interval (CI) 0.65\u20130.88; <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001) and extended follow\u2010up (1.15% vs. 1.43%, OR 0.80, 95% CI 0.65\u20130.98; <jats:italic>p<\/jats:italic>\u2009=\u2009.032). This was driven by a lower rate of vascular complications during early follow\u2010up in the VCD cohort (0.83% vs. 1.26%, OR 0.66, 95% CI 0.52\u20130.83; <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001), and fewer bleeding events during early (0.90% vs. 1.23%, OR 0.73, 95% CI 0.58\u20130.92; <jats:italic>p<\/jats:italic>\u2009=\u2009.007) and extended follow\u2010up (0.36% vs. 0.59%, OR 0.61, 95% CI 0.43\u20130.86; <jats:italic>p<\/jats:italic>\u2009=\u2009.005).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Following AF ablation, femoral venous hemostasis with a VCD was associated with reduced complications compared with hemostasis without a VCD.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jce.16345","type":"journal-article","created":{"date-parts":[[2024,6,26]],"date-time":"2024-06-26T05:13:30Z","timestamp":1719378810000},"page":"1656-1662","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Outcomes of vascular closure devices for femoral venous hemostasis following catheter ablation of atrial fibrillation"],"prefix":"10.1111","volume":"35","author":[{"given":"Mark T.","family":"Mills","sequence":"first","affiliation":[{"name":"Department of Cardiology Liverpool Heart &amp; Chest Hospital Liverpool UK"},{"name":"Liverpool Centre for Cardiovascular Science at University of Liverpool, Liverpool John Moores University and Liverpool Heart &amp; Chest Hospital Liverpool UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8401-4033","authenticated-orcid":false,"given":"Peter","family":"Calvert","sequence":"additional","affiliation":[{"name":"Department of Cardiology Liverpool Heart &amp; Chest Hospital Liverpool UK"},{"name":"Liverpool Centre for Cardiovascular Science at University of Liverpool, Liverpool John Moores University and Liverpool Heart &amp; Chest Hospital Liverpool UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory Y. H.","family":"Lip","sequence":"additional","affiliation":[{"name":"Department of Cardiology Liverpool Heart &amp; Chest Hospital Liverpool UK"},{"name":"Liverpool Centre for Cardiovascular Science at University of Liverpool, Liverpool John Moores University and Liverpool Heart &amp; Chest Hospital Liverpool UK"},{"name":"Department of Clinical Medicine, Danish Center for Health Services Research Aalborg University Aalborg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3274-7128","authenticated-orcid":false,"given":"Vishal","family":"Luther","sequence":"additional","affiliation":[{"name":"Department of Cardiology Liverpool Heart &amp; Chest Hospital Liverpool UK"},{"name":"Liverpool Centre for Cardiovascular Science at University of Liverpool, Liverpool John Moores University and Liverpool Heart &amp; Chest Hospital Liverpool UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3490-090X","authenticated-orcid":false,"given":"Dhiraj","family":"Gupta","sequence":"additional","affiliation":[{"name":"Department of Cardiology Liverpool Heart &amp; Chest Hospital Liverpool UK"},{"name":"Liverpool Centre for Cardiovascular Science at University of Liverpool, Liverpool John Moores University and Liverpool Heart &amp; Chest Hospital Liverpool UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,6,25]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2023.03.418"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/euad361"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2011.05.017"},{"issue":"3","key":"e_1_2_7_5_1","first-page":"693","article-title":"Incidence of vascular complications for electrophysiology procedures in the ultrasound era: a single\u2010centre experience over 10,000 procedures in the long term","volume":"66","author":"Ding WY","year":"2022","journal-title":"J Interv Card Electrophysiol"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.33963\/KP.a2022.0148"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/euz004"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacep.2019.08.013"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10840-021-00981-5"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacep.2023.06.008"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.121.020804"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2012.96867"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/euab116.221"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/jce.15555"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcha.2016.09.002"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1177\/159101991301900313"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2006.10.032"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2024.03.1244"}],"container-title":["Journal of Cardiovascular Electrophysiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jce.16345","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,17]],"date-time":"2024-12-17T05:37:35Z","timestamp":1734413855000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jce.16345"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,25]]},"references-count":17,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2024,8]]}},"alternative-id":["10.1111\/jce.16345"],"URL":"https:\/\/doi.org\/10.1111\/jce.16345","archive":["Portico"],"relation":{},"ISSN":["1045-3873","1540-8167"],"issn-type":[{"value":"1045-3873","type":"print"},{"value":"1540-8167","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,6,25]]},"assertion":[{"value":"2024-04-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-06-06","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-06-25","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}