{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T05:56:19Z","timestamp":1772171779590,"version":"3.50.1"},"reference-count":12,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2024,6,25]],"date-time":"2024-06-25T00:00:00Z","timestamp":1719273600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>The dST\u2010Tiso is a newly proposed electrocardiographic (ECG) marker during Brugada (BrS) type I pattern, that predicts the likelihood of ventricular arrhythmia (VA) inducibility in patients with ajmaline\u2010induced pattern. The objective of this study was to validate the effectiveness of this criterion using an independent data set.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Consecutive patients exhibiting a BrS type I ECG pattern following ajmaline administration underwent programmed ventricular stimulation (PVS). dST\u2010Tiso interval was measured in all patients and tested as a predictor for positive VA inducibility.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 128 patients (median age 43 years, 59% male) with drug\u2010induced BrS type I ECG pattern who underwent PVS, 32 (25.0%) had VA inducibility that required defibrillation. Compared to noninducible subjects, those with positive PVS were more commonly male (81% vs. 51%, <jats:italic>p<\/jats:italic>\u2009=\u20090.003), had longer PQ (165 vs. 160\u2009ms, <jats:italic>p<\/jats:italic>\u2009=\u20090.016) and dST\u2010Tiso (310 vs. 230\u2009ms, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) intervals, and shorter QT interval (412 vs. 420\u2009ms, <jats:italic>p<\/jats:italic>\u2009=\u20090.022). When treated as a continuous variable, dST\u2010Tiso confirmed significant association with VA inducibility, with an adjusted odds ratio of 1.02 (95% confidence interval: 1.01\u20131.03, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) for each 1\u2009ms increase in duration. A dST\u2010Tiso interval &gt;300\u2009ms yielded a sensitivity of 75%, a specificity of 86%, and positive and negative predictive values of 69% and 91%, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The validation of the model based on the dST\u2010Tiso interval &gt;300\u2009ms confirmed its high accuracy in predicting VA inducibility in drug\u2010induced BrS type I pattern. This straightforward ECG marker might be linked to the extent of the electrical substrate of the disease.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jce.16348","type":"journal-article","created":{"date-parts":[[2024,6,26]],"date-time":"2024-06-26T05:05:29Z","timestamp":1719378329000},"page":"1747-1753","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Predicting ventricular arrhythmia inducibility in ajmaline\u2010induced Brugada type I pattern: Validation of the dST\u2010Tiso interval"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2131-1110","authenticated-orcid":false,"given":"Saverio","family":"Iacopino","sequence":"first","affiliation":[{"name":"Maria Cecilia Hospital GVM Care &amp; Research Cotignola Ravenna Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emmanuel","family":"Fabiano","sequence":"additional","affiliation":[{"name":"Maria Cecilia Hospital GVM Care &amp; Research Cotignola Ravenna Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paolo","family":"Sorrenti","sequence":"additional","affiliation":[{"name":"Maria Cecilia Hospital GVM Care &amp; Research Cotignola Ravenna Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Petretta","sequence":"additional","affiliation":[{"name":"Maria Cecilia Hospital GVM Care &amp; Research Cotignola Ravenna Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacopo","family":"Colella","sequence":"additional","affiliation":[{"name":"Maria Cecilia Hospital GVM Care &amp; Research Cotignola Ravenna Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandro","family":"Di Vilio","sequence":"additional","affiliation":[{"name":"Maria Cecilia Hospital GVM Care &amp; Research Cotignola Ravenna Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanni","family":"Statuto","sequence":"additional","affiliation":[{"name":"Maria Cecilia Hospital GVM Care &amp; Research Cotignola Ravenna Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pasquale","family":"Filannino","sequence":"additional","affiliation":[{"name":"Maria Cecilia Hospital GVM Care &amp; Research Cotignola Ravenna Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paolo","family":"Artale","sequence":"additional","affiliation":[{"name":"Maria Cecilia Hospital GVM Care &amp; Research Cotignola Ravenna Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1584-7944","authenticated-orcid":false,"given":"Daniele","family":"Giacopelli","sequence":"additional","affiliation":[{"name":"Clinical Research Unit BIOTRONIK Italia Vimodrone Milano Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gianluca","family":"Peluso","sequence":"additional","affiliation":[{"name":"Maria Cecilia Hospital GVM Care &amp; Research Cotignola Ravenna Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gennaro","family":"Fabiano","sequence":"additional","affiliation":[{"name":"Maria Cecilia Hospital GVM Care &amp; Research Cotignola Ravenna Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"Campagna","sequence":"additional","affiliation":[{"name":"Maria Cecilia Hospital GVM Care &amp; Research Cotignola Ravenna Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Federico","family":"Cecchini","sequence":"additional","affiliation":[{"name":"Maria Cecilia Hospital GVM Care &amp; Research Cotignola Ravenna Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,6,25]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehx490"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehac262"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2021.08.014"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2011.08.064"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-130-6-199903160-00016"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.123.064689"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2014.10.007"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2013.09.060"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2022.931622"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartjsupp\/suad035"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.121.010004"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/euac168"}],"container-title":["Journal of Cardiovascular Electrophysiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jce.16348","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,19]],"date-time":"2024-11-19T11:51:58Z","timestamp":1732017118000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jce.16348"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,25]]},"references-count":12,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2024,9]]}},"alternative-id":["10.1111\/jce.16348"],"URL":"https:\/\/doi.org\/10.1111\/jce.16348","archive":["Portico"],"relation":{},"ISSN":["1045-3873","1540-8167"],"issn-type":[{"value":"1045-3873","type":"print"},{"value":"1540-8167","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,6,25]]},"assertion":[{"value":"2023-12-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-06-08","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-06-25","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}