{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T15:39:04Z","timestamp":1770824344491,"version":"3.50.1"},"reference-count":38,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2024,7,12]],"date-time":"2024-07-12T00:00:00Z","timestamp":1720742400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Scar substrate in nonischemic cardiomyopathy (NICM) patients is often difficult to identify. Advances in cardiac imaging, especially using late iodine\u2010enhanced computed tomography (LIE\u2010CT), allow better characterization of scars giving rise to ventricular tachycardia (VT). Currently, there are limited data on clinical correlates of CT\u2010derived scar substrates in NICM. We sought assess the relationship between scar location on LIE\u2010CT and outcomes after radiofrequency catheter ablation (RFCA) in NICM patients with VT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>From 2020 to 2022, consecutive patients with NICM undergoing VT RFCA with integration of cardiac CT scar modeling (inHeart, Pessac, France) were included at two US tertiary care centers. The CT protocol included both arterial\u2010enhanced imaging for anatomical modeling and LIE\u2010CT for scar assessment. The distribution of substrate on CT was analyzed in relation to patient outcomes, with primary endpoints being VT recurrence and the need for repeat ablation procedure.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Sixty patients were included (age 64\u2009\u00b1\u200912 years, 90% men). Over a median follow\u2010up of 120 days (interquartile range [IQR]: 41\u2013365), repeat ablation procedures were required in 32 (53%). VT recurrence occurred in 46 (77%), with a median time to recurrence of 40 days (IQR: 8\u201365). CT\u2010derived total scar volume positively correlated with intrinsic QRS duration (<jats:italic>r<\/jats:italic>\u2009=\u2009.34, <jats:italic>p<\/jats:italic>\u2009=\u20090.008). Septal scar was found on CT in 34 (57%), and lateral scar in 40 (7%). On univariate logistic regression, septal scar was associated with increased odds of repeat ablation (odds ratio [OR]: 2.9 [1.0\u20138.4]; <jats:italic>p<\/jats:italic>\u2009=\u20090.046), while lateral scar was not (OR: 0.9 [0.3\u20132.7]; <jats:italic>p<\/jats:italic>\u2009=\u20090.855). Septal scar better predicted VT recurrence when compared to lateral scar, but neither were statistically significant (septal scar OR: 3.0 [0.9\u201310.7]; <jats:italic>p<\/jats:italic>\u2009=\u20090.078; lateral scar OR: 1.7 [0.5\u20135.9]; <jats:italic>p<\/jats:italic>\u2009=\u20090.391).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In this tertiary care referral population, patients with NICM undergoing VT catheter ablation with septal LIE\u2010CT have nearly threefold increased risk of need for repeat ablation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jce.16356","type":"journal-article","created":{"date-parts":[[2024,7,12]],"date-time":"2024-07-12T10:05:21Z","timestamp":1720778721000},"page":"1806-1816","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Septal late enhancement by cardiac CT is associated with repeat ablation in nonischemic cardiomyopathy patients"],"prefix":"10.1111","volume":"35","author":[{"given":"Leah A.","family":"John","sequence":"first","affiliation":[{"name":"Cardiovascular Division, Department of Medicine Brigham and Women's Hospital Boston Massachusetts USA"},{"name":"Division of Cardiology Medical University of South Carolina Charleston South Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sanjay","family":"Divakaran","sequence":"additional","affiliation":[{"name":"Cardiovascular Division, Department of Medicine Brigham and Women's Hospital Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ron","family":"Blankstein","sequence":"additional","affiliation":[{"name":"Cardiovascular Division, Department of Medicine Brigham and Women's Hospital Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Uyanga","family":"Batnyam","sequence":"additional","affiliation":[{"name":"Cardiovascular Division, Department of Medicine Brigham and Women's Hospital Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pal","family":"Suranyi","sequence":"additional","affiliation":[{"name":"Division of Cardiology Medical University of South Carolina Charleston South Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mathew","family":"Gregoski","sequence":"additional","affiliation":[{"name":"Division of Cardiology Medical University of South Carolina Charleston South Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hubert","family":"Cochet","sequence":"additional","affiliation":[{"name":"Institut Hospitalo\u2010Universitaire Liryc Bordeaux France"},{"name":"Bordeaux University Hospital Bordeaux France"},{"name":"inHEART Bordeaux\u2010Pessac France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean\u2010Marc","family":"Peyrat","sequence":"additional","affiliation":[{"name":"inHEART Bordeaux\u2010Pessac 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