{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T18:49:17Z","timestamp":1773686957609,"version":"3.50.1"},"reference-count":38,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2024,9,30]],"date-time":"2024-09-30T00:00:00Z","timestamp":1727654400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Pericardial effusion, a known complication to implantation of cardiac implantable electronic devices (CIED), may cause life\u2010threatening cardiac tamponade. Limited knowledge is available about risk factors for clinically relevant procedural pericardial effusion. The aim is to identify the patient\u2010 and procedure\u2010related risk factors associated with clinically relevant procedural pericardial effusion.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>A nationwide observational cohort study based on data on 55 121 patients from the Danish Pacemaker Register between 2000 and 2018. We defined a clinically relevant procedural pericardial effusion related to the implantation if it occurred within 90 days after the primary CIED\u2010procedure. Prespecified risk factors were analysed by multivariable logistic regression models to estimate the association with pericardial effusion.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were 115 (0.21%) patients diagnosed with clinically relevant procedural pericardial effusion, with a median age of 75 years and 38.3% were females. Of these, 80.9% lead to a subsequent pericardiocentesis procedure. In adjusted logistic regression analysis, an increased risk of clinically relevant pericardial effusion was associated with female sex (OR:1.49 [95%CI: 1.03\u20132.16]), heart failure (OR:1.54 [95%CI: 1.06\u20132.23]), previous cardiac surgery (OR:1.63 [95%CI: 1.05\u20132.55]), CRT\u2010device (OR:2.05 [95%CI: 1.23\u20133.41]), tertiary\u2010centres (OR:1.8 [95%CI: 1.18\u20132.73]), increased procedural volume per year (&gt;1000) (OR:1.85 [95%CI: 1.03\u20133.30]), indication of device\u2010implantation (atrioventricular block) (OR:2.37 [95CI: 1.45\u20133.87]), and increasing number of leads implanted (two leads (OR:2.39 [95%CI: 1.43\u20134.00]), three leads (OR:4.77 [95%CI: 2.50\u20139.10])).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Clinically relevant procedural pericardial effusion is a rare complication after CIED\u2010implantation in Denmark. This study reveals important patient\u2010 and procedure\u2010related risk factors associated with clinically relevant procedural pericardial effusion.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jce.16442","type":"journal-article","created":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T04:16:47Z","timestamp":1727756207000},"page":"2314-2328","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Risk factors associated with clinically relevant pericardial effusion after primary cardiac implantable electronic device implantation"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-3716-5522","authenticated-orcid":false,"given":"Yangzhi","family":"Zhou","sequence":"first","affiliation":[{"name":"Department of Cardiology Bispebjerg and Frederiksberg Hospital Copenhagen 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