{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T07:41:35Z","timestamp":1775634095484,"version":"3.50.1"},"reference-count":34,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2024,9,30]],"date-time":"2024-09-30T00:00:00Z","timestamp":1727654400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Obesity is implicated in adverse atrial remodeling and worse outcomes in patients with atrial fibrillation. The objective of this study is to assess the effect of body mass index (BMI) on ablation\u2010induced scar formation on late gadolinium enhancement cardiac magnetic resonance imaging (LGE\u2010CMR).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted an analysis of DECAAF II participants who underwent LGE\u2010CMR scans to measure scar formation 3 months after catheter ablation. Ablation parameters and lesion delivery were not dependent on BMI. The effect of BMI on ablation success was explored.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Our analyses included 811 patients. Comorbidities were more prevalent in obese patients. Baseline left atrial volume was higher in obese individuals, 118, 126, 135, 140, and 143\u2009mm<jats:sup>3<\/jats:sup> for normal weight, overweight, obese grade 1, 2, and 3, respectively (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001). BMI was associated with scar formation (R\u2009=\u2009\u22120.135, <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001), with patients with Class 3 obesity having the lowest percentage of ablation\u2010induced scar, 11.1%, 10.3%, 9.5%, 8.8%, 6.8% by ascending BMI group. There was an inverse correlation between BMI and the amount of fibrosis covered by ablation scar, 24%, 23%, 21%, and 18% by ascending BMI group (<jats:italic>p<\/jats:italic>\u2009=\u2009.001). For the fibrosis\u2010guided ablation group, BMI was associated with residual fibrosis (R\u2009=\u20090.056, <jats:italic>p<\/jats:italic>\u2009=\u2009.005).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Obese patients have lower ablation scar formation, covered fibrosis, and more residual fibrosis postablation compared to nonobese patients, regardless of ablation parameters including impedance drop.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jce.16448","type":"journal-article","created":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T04:38:38Z","timestamp":1727757518000},"page":"2330-2341","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Body mass index as a determinant of scar formation post\u2010AF ablation: Insights from DECAAF II"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3562-7386","authenticated-orcid":false,"given":"Ghassan","family":"Bidaoui","sequence":"first","affiliation":[{"name":"Tulane Research Innovation for Arrhythmia Discovery (TRIAD), Cardiac Electrophysiology Tulane University School of Medicine New Orleans Louisiana USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-2542-941X","authenticated-orcid":false,"given":"Eli","family":"Tsakiris","sequence":"additional","affiliation":[{"name":"Tulane Research Innovation for Arrhythmia Discovery (TRIAD), Cardiac Electrophysiology Tulane University School of Medicine New Orleans Louisiana USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7202-1164","authenticated-orcid":false,"given":"Hadi","family":"Younes","sequence":"additional","affiliation":[{"name":"Tulane Research Innovation for Arrhythmia Discovery 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