{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T06:11:46Z","timestamp":1787983906665,"version":"build-2784847793"},"reference-count":30,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2024,10,15]],"date-time":"2024-10-15T00:00:00Z","timestamp":1728950400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Real\u2010world studies comparing safety and efficacy of combined percutaneous left atrial appendage occlusion (LAAO) and catheter ablation (CA) to LAAO alone are limited.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Patients from a large US hospital system undergoing combined LAAO and left\u2010atrial CA from 8\/2020 to 2\/2024 were retrospectively analyzed and compared to a control group undergoing LAAO alone. Controls were identified using a 1:2 propensity score match based on LAAO device type (Watchman FLX vs. Amulet), CHA\n                      <jats:sub>2<\/jats:sub>\n                      D\n                      <jats:sub>2<\/jats:sub>\n                      \u2010VASc and Hypertension, Abnormal renal\/liver function, Stroke, Bleeding history or predisposition, Labile international normalized ratio [INR], Elderly, Drugs\/alcohol (HAS\u2010BLED) scores and compared for safety, sealing performance and clinical outcomes at 6 months.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Patients were younger in the combined (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200972) than in the control group (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009144, 70.2\u2009\u00b1\u20097.3 vs. 76.7\u2009\u00b1\u20096.9 years,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) but otherwise comparable with a mean CHA\n                      <jats:sub>2<\/jats:sub>\n                      D\n                      <jats:sub>2<\/jats:sub>\n                      \u2010VASc score of 4.2\u2009\u00b1\u20091.1 and 4.4\u2009\u00b1\u20091.2 (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.26) and HAS\u2010BLED score of 2.2\u2009\u00b1\u20090.8 and 2.3\u2009\u00b1\u20090.7 (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.34). Successful LAAO implantation rates were the same (95.8% vs. 95.8%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.99) with longer procedure times seen in the combined group (156.5\u2009\u00b1\u200953 vs. 56\u2009\u00b1\u200926\u2009min,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Both major (1.4% vs. 2.1%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.72) and minor (27.8% vs. 19.4%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.17) in\u2010hospital complications were similar between the combined and control group, respectively. At 45 days, presence of peri\u2010device leak (18.3% vs. 30.4%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.07) and device related thrombosis (4.5% vs. 4.5%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.96) on transesophageal echocardiogram did not differ. Finally, all\u2010cause mortality (0% vs. 1.4%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.99), thromboembolic (0% vs. 0%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.99) and bleeding (6.1% vs. 4.4%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.73) events during follow\u2010up were comparable.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This large, real\u2010world analysis indicates comparable safety and efficiency of combined LAAO and CA when compared with LAAO alone.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jce.16466","type":"journal-article","created":{"date-parts":[[2024,10,16]],"date-time":"2024-10-16T00:26:09Z","timestamp":1729038369000},"page":"2423-2431","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Combined left atrial appendage occlusion and catheter ablation procedure for left atrial arrhythmias: A real\u2010world, propensity\u2010matched analysis"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2320-5175","authenticated-orcid":false,"given":"Stefan","family":"Preisend\u00f6rfer","sequence":"first","affiliation":[{"name":"Heart &amp; Vascular Institute, University of Pittsburgh Medical Center Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad T.","family":"Ayub","sequence":"additional","affiliation":[{"name":"Heart &amp; Vascular Institute, University of Pittsburgh Medical Center Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aakash","family":"Sheth","sequence":"additional","affiliation":[{"name":"Heart &amp; Vascular Institute, University of Pittsburgh Medical Center Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George Y.","family":"Jabbour","sequence":"additional","affiliation":[{"name":"Heart &amp; Vascular Institute, University of Pittsburgh Medical Center Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madhurmeet","family":"Singh","sequence":"additional","affiliation":[{"name":"Heart &amp; Vascular Institute, University of Pittsburgh Medical Center Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chinmay P.","family":"Patel","sequence":"additional","affiliation":[{"name":"Heart &amp; 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Vascular Institute, University of Pittsburgh Medical Center Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krishna","family":"Kancharla","sequence":"additional","affiliation":[{"name":"Heart &amp; Vascular Institute, University of Pittsburgh Medical Center Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dustin E.","family":"Kliner","sequence":"additional","affiliation":[{"name":"Heart &amp; Vascular Institute, University of Pittsburgh Medical Center Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amber","family":"Makani","sequence":"additional","affiliation":[{"name":"Heart &amp; Vascular Institute, University of Pittsburgh Medical Center Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aditi","family":"Naniwadekar","sequence":"additional","affiliation":[{"name":"Heart &amp; Vascular Institute, University of Pittsburgh Medical Center Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2000-7678","authenticated-orcid":false,"given":"Alaa","family":"Shalaby","sequence":"additional","affiliation":[{"name":"Heart &amp; 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