{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T11:26:13Z","timestamp":1740137173838,"version":"3.37.3"},"reference-count":31,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,11,7]],"date-time":"2024-11-07T00:00:00Z","timestamp":1730937600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Left bundle branch area pacing (LBBAP) and endocardial resynchronization (Endo\u2010CRT) are alternatives to biventricular pacing for cardiac resynchronization therapy (CRT).<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To compare the outcomes of LBBAP versus Endo\u2010CRT using conventional pacing leads.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients with heart failure (HF) undergoing CRT with LBBAP or Endo\u2010CRT were included. The primary efficacy outcome was a composite of HF\u2010related hospitalization and all\u2010cause mortality. The primary safety outcome was any procedure\u2010related complication. Secondary outcomes included procedural characteristics, electrocardiographic, and echocardiographic parameters.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 223 patients (LBBAP <jats:italic>n<\/jats:italic>\u2009=\u2009197, Endo\u2010CRT <jats:italic>n<\/jats:italic>\u2009=\u200926; mean age 69\u2009\u00b1\u200910.3 years, 32.3% female) were included. Patients in the LBBAP group had lower NYHA class, shorter preprocedural QRS durations (161 [142\u2013183] vs. 180 [170\u2013203] msec, <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001), and a lower preprocedural spironolactone use (57.4% vs. 84.6%, <jats:italic>p<\/jats:italic>\u2009=\u2009.009) than patients in the Endo\u2010CRT group. Fluoroscopy time was significantly shorter in patients undergoing LBBAP (11.4 [7.2\u201320] vs. 23 [14.2\u201334.5] min; <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001). There was no significant difference in the primary efficacy outcome between both groups (Cox proportional HR 1.21, 95% CI 0.635\u20132.31; <jats:italic>p<\/jats:italic>\u2009=\u2009.56). During follow\u2010up, patients undergoing LBBAP had a lower incidence of stroke than patients in the Endo\u2010CRT group (0% vs. 11.5%, <jats:italic>p<\/jats:italic>\u2009=\u2009.001). Postprocedural LVEF (35% [25\u201345] vs. 40% [20\u201355]; <jats:italic>p<\/jats:italic>\u2009=\u2009.307) and change in LVEF (7% [0\u201320] vs. 11% [2\u201318]; <jats:italic>p<\/jats:italic>\u2009=\u2009.384) were similar between the LBBAP and the Endo\u2010CRT groups, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>LBBAP and Endo\u2010CRT using conventional leads are associated with similar mortality and HF\u2010related hospitalization, as well as improvements in LVEF. Endo\u2010CRT is associated with longer fluoroscopy times and a higher risk of stroke.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jce.16479","type":"journal-article","created":{"date-parts":[[2024,11,8]],"date-time":"2024-11-08T05:39:01Z","timestamp":1731044341000},"page":"135-143","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Left bundle branch area pacing versus endocardial resynchronization in patients with heart failure"],"prefix":"10.1111","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0887-1700","authenticated-orcid":false,"given":"Juan Carlos","family":"Diaz","sequence":"first","affiliation":[{"name":"Division of Cardiology Cardiac Arrhythmia and Electrophysiology Service, Clinica Las Vegas Medellin Colombia"},{"name":"Universidad CES School of Medicine Medellin 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