{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T11:26:13Z","timestamp":1740137173817,"version":"3.37.3"},"reference-count":40,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,11,15]],"date-time":"2024-11-15T00:00:00Z","timestamp":1731628800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Guidance and outcomes of coronary ischemia assessment (IA) in those with structural heart disease (SHD), presenting with monomorphic ventricular tachycardia (MMVT) is unclear.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To assess the impact of IA on arrhythmic and non\u2010arrhythmic outcomes in those with SHD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients presenting with MMVT over a 6\u2010year period to a tertiary center were retrospectively analyzed. Propensity score\u2010matched analysis was performed comparing those undergoing IA to those who did not. The primary endpoint was a composite of VT recurrence, appropriate ICD therapy, heart failure hospitalization, and death. Secondary analysis of the individual components of the composite was performed. Kaplan\u2013Meier, univariate and multivariate analysis was performed to compare the two groups and derive predictors of poor outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Two hundred and seventeen patients (57.6% ICM) were analyzed. 55.8% underwent IA. Following propensity score\u2010matching, 120 patients remained. At 12 months, freedom from the primary endpoint was 68.3% of those undergoing IA versus 43.3% who did not, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001, multivariate HR 0.56 (0.34\u20130.92). This was driven by a reduction in all\u2010cause mortality, with a 12\u2010month survival of 98.3% in those undergoing IA versus 86.5% in those not undergoing IA (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01). Coronary intervention was associated with a significantly higher event\u2010free 12\u2010month survival compared to those who did not undergo intervention (82.4% vs 51.5%, respectively, <jats:italic>p<\/jats:italic>\u2009=\u20090.01).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Patients with SHD presenting MMVT who undergo an IA have significantly improved freedom from VT recurrence, appropriate ICD therapies, HF hospitalization, and death compared to those who do not, driven by a reduction in mortality.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jce.16495","type":"journal-article","created":{"date-parts":[[2024,11,16]],"date-time":"2024-11-16T03:20:06Z","timestamp":1731727206000},"page":"201-211","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Impact of Coronary Ischemia Assessment on Outcomes in Those With Scar\u2010Dependent Ventricular Tachycardia"],"prefix":"10.1111","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8714-5808","authenticated-orcid":false,"given":"Michael C.","family":"Waight","sequence":"first","affiliation":[{"name":"City St George's University of London London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5622-3233","authenticated-orcid":false,"given":"Davide","family":"Fabbricatore","sequence":"additional","affiliation":[{"name":"St George's University Hospitals NHS Foundation Trust London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8731-2853","authenticated-orcid":false,"given":"Elijah R.","family":"Behr","sequence":"additional","affiliation":[{"name":"City St George's University of London London UK"},{"name":"St George's University Hospitals NHS Foundation Trust London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5771-5504","authenticated-orcid":false,"given":"Manav","family":"Sohal","sequence":"additional","affiliation":[{"name":"St George's University Hospitals NHS Foundation Trust London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5516-1117","authenticated-orcid":false,"given":"Anthony C.","family":"Li","sequence":"additional","affiliation":[{"name":"City St George's University of London London UK"},{"name":"St George's University Hospitals NHS Foundation Trust London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0134-4214","authenticated-orcid":false,"given":"Magdi M.","family":"Saba","sequence":"additional","affiliation":[{"name":"City St George's University of London London UK"},{"name":"St George's University Hospitals NHS Foundation Trust London UK"},{"name":"Cleveland Clinic of London London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,11,15]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.51.4.606"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-8703(89)90670-4"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10102183"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCIMAGING.114.002332"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehac262"},{"key":"e_1_2_10_7_1","first-page":"272","article-title":"2017 Aha\/Acc\/Hrs Guideline for Management of Patients With Ventricular Arrhythmias and the Prevention of Sudden Cardiac Death","volume":"138","author":"Al\u2010Khatib S. 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