{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T08:10:52Z","timestamp":1791447052895,"version":"4.3.3"},"reference-count":29,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,11,26]],"date-time":"2024-11-26T00:00:00Z","timestamp":1732579200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Little is known about age and clinical intervention after implantable loop recorder (ILR) insertion. This study investigated the association between age and clinical intervention after ILR implantation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and Results<\/jats:title><jats:p>Data were obtained from a multicenter registry of ILR in Korea (2017\u20132020, <jats:italic>n<\/jats:italic>\u2009=\u2009795). ILRs were inserted with indications of unexplained syncope, recurrent palpitation, or cryptogenic stroke. The primary outcome was clinically actionable event that was a composite of the newly detected atrial fibrillation (AF), pacemaker or implantable cardioverter defibrillator (ICD) implantation, catheter ablation, and anticoagulation initiation. The mean age was 64.3 years, and the mean follow\u2010up duration was 20.6 months. Clinically actionable events were observed in 322 (40.5%) patients. Compared to younger age (&lt;\u200950 years), older age (\u2265\u200950 years) showed higher prevalence of newly detected AF (3.7% vs. 15.8%; <jats:italic>p<\/jats:italic>\u2009=\u20090.001), pacemaker implantation (11.2% vs. 21.2%; <jats:italic>p<\/jats:italic>\u2009=\u20090.022), and initiation of anticoagulation (3.7% vs. 18.6%; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). No significant differences were found in ICD implantation (1.9% vs. 1.3%; <jats:italic>p<\/jats:italic>\u2009=\u20090.996) or catheter ablation (3.8% vs. 6.0%; <jats:italic>p<\/jats:italic>\u2009=\u20090.512). The older age group more frequently experienced clinically actionable events compared to the younger age group (hazard ratio 2.52, 95% confidence interval: 1.86\u20133.41; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). A significant association was found in the increase of age (per 1\u2010year) and the risk of clinically actionable events (adjusted hazard ratio 1.03, 95% confidence interval 1.02\u20131.04; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Advanced age is a significant risk factor for clinical intervention after ILR insertion. ILR should be considered more actively in older patients requiring prolonged rhythm monitoring.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jce.16509","type":"journal-article","created":{"date-parts":[[2024,11,27]],"date-time":"2024-11-27T05:29:45Z","timestamp":1732685385000},"page":"266-275","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Age and Clinically Actionable Events in Patients With Implantable Loop Recorders: Analysis of Multicenter Loop Recorder Registry"],"prefix":"10.1111","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8308-0197","authenticated-orcid":false,"given":"Joo Hee","family":"Jeong","sequence":"first","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine Korea University College of Medicine and Korea University Anam Hospital Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6351-5015","authenticated-orcid":false,"given":"So\u2010Ryoung","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Seoul National University Hospital Seoul South Korea"},{"name":"Department of Internal Medicine Seoul National University College of Medicine Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Il\u2010Young","family":"Oh","sequence":"additional","affiliation":[{"name":"Cardiovascular Center Seoul National University Bundang Hospital, Seoul National University College of Medicine Seongnam South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myung\u2010Jin","family":"Cha","sequence":"additional","affiliation":[{"name":"Heart Institute University of Ulsan College of Medicine, Asan Medical Center Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8102-8352","authenticated-orcid":false,"given":"Hong Euy","family":"Lim","sequence":"additional","affiliation":[{"name":"Division of Cardiology Hallym University Sacred Heart Hospital, Hallym University College of Medicine Anyang South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyoung\u2010Seob","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Keimyung University Dongsan Medical Center. Keimyung University College of Medicine Daegu South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pil\u2010Sung","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, CHA Bundang Medical Center CHA University Seongnam South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sung Ho","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Kangbuk Samsung Hospital Sungkyunkwan University School of Medicine Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junbeom","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Cardiology, School of Medicine Ewha Womans University Seoul South 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