{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T15:47:32Z","timestamp":1768405652012,"version":"3.49.0"},"reference-count":26,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,1,7]],"date-time":"2025-01-07T00:00:00Z","timestamp":1736208000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>Data are scarce regarding Wolf\u2010Parkinson White Syndrome (WPW) syndrome and asymptomatic pre\u2010excitation in Africa. This study tried to understand the current approaches utilized in Africa for the diagnosis and management of both symptomatic and asymptomatic ventricular pre\u2010excitation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The current prospective study was conducted in 20 centers located in 17 countries spanning all areas of Africa. Participants included had ventricular pre\u2010excitation patterns. The data collected included symptoms, locations of accessory pathways (AP) and tachyarrhythmia, risk stratification, as well as acute and long\u2010term management. In addition, we assessed the clinical effectiveness of the centers and the impact of socioeconomic and health metrics on these treatment approaches.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 541 participants, 93% were diagnosed with WPW syndrome, with orthodromic atrioventricular reciprocating tachycardia (AVRT) being the most prevalent arrhythmia, affecting 55% of the cases. Approximately 30% of patients in Africa, except for the southern region, received intravenous amiodarone as the first\u2010choice drug for orthodromic AVRT while adenosine was the drug of choice in the Southern region. Electrical cardioversion was the first\u2010line treatment for pre\u2010excited atrial fibrillation and antidromic AVRT across all of Africa. Radiofrequency ablation (RF) was the first long\u2010term therapy option for 88% of patients in all African regions, unlike western and central Africa where it was implemented for less than 30% of patients (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). The rates of RF success, long\u2010term recurrence, and complications were 93%, 4.1%, and 3.8%, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>There are significant variations between African regions in terms of diagnostic workup, accessory pathway localizations, and volume of invasive treatment. Countries in Northern and Southern Africa are more advanced than other African countries in terms of modern management strategy. Additional government investments are necessary to enhance diagnostic likelihood and curative treatments as well as to reduce the gap between different regions in Africa.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jce.16523","type":"journal-article","created":{"date-parts":[[2025,1,7]],"date-time":"2025-01-07T06:07:40Z","timestamp":1736230060000},"page":"2117-2131","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Clinical Profile and Management of Wolf\u2010Parkinson White Syndrome and Asymptomatic Pre\u2010Excitation Carriers in Africa: A Multicenter Pan African Registry From 17 Countries"],"prefix":"10.1111","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0648-9196","authenticated-orcid":false,"given":"Lamyaa","family":"Allam","sequence":"first","affiliation":[{"name":"Cardiology Department, Faculty of Medicine Ain Shams University Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean Timnou","family":"Bekouti","sequence":"additional","affiliation":[{"name":"Interventional Cardiology Center of Douala Douala Cameroon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed Diaa","family":"Gabra","sequence":"additional","affiliation":[{"name":"Faculty of Medicine South Valley University Qena Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tolulope Taiwo","family":"Shogade","sequence":"additional","affiliation":[{"name":"Cardiology Unit, Department of Internal Medicine University of Uyo Teaching Hospital Uyo Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hazem Mohamed","family":"El\u2010Hariri","sequence":"additional","affiliation":[{"name":"Community Medicine Department National Research Centre Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ait Messaoudene Mohamed","family":"Seddik","sequence":"additional","affiliation":[{"name":"CHU Mustapha Cardiologi Algiers Algeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bouasria","family":"Kahled","sequence":"additional","affiliation":[{"name":"CHU Mustapha Algiers Algeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian","family":"Vezi","sequence":"additional","affiliation":[{"name":"EThekwini Hospital Durban South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariem","family":"Jabeur","sequence":"additional","affiliation":[{"name":"Hedi Chaker University Hospital of Sfax Sfax Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pessinaba","family":"Soulemane","sequence":"additional","affiliation":[{"name":"Campus Teaching Hospital Lom\u00e9 Togo"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arnaud","family":"Sonou","sequence":"additional","affiliation":[{"name":"National Teaching Hospital Hubert Koutoukou Maga Cotonou Benin Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael Rory","family":"Alison","sequence":"additional","affiliation":[{"name":"Lady Pohamba Private Hospital Windhoek Namibia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lemon\u00e9","family":"Houchinne","sequence":"additional","affiliation":[{"name":"Clinique Maison du Coeur N'Djam\u00e9na Chad"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Allah\u2010Amine","family":"Adjougoulta Koboy","sequence":"additional","affiliation":[{"name":"CHU la R\u00e9f\u00e9rence Nationale N'Djam\u00e9na Chad"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9","family":"Roberto","sequence":"additional","affiliation":[{"name":"Clinica sagrada esperanca Luanda Angola"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kouame Koffi","family":"Stephane","sequence":"additional","affiliation":[{"name":"Institut de cardiologie CHU Treichville Abidjan C\u00f4te D'Ivoire"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adama","family":"Diakit\u00e9","sequence":"additional","affiliation":[{"name":"CSREF Commune 2 Bamako Mali"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ikama M\u00e9o","family":"St\u00e9phane","sequence":"additional","affiliation":[{"name":"CHU de Brazzaville Brazzaville Congo"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Avinash","family":"Jeewoth","sequence":"additional","affiliation":[{"name":"Dr. A.G. 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