{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,3]],"date-time":"2025-07-03T04:05:53Z","timestamp":1751515553357,"version":"3.41.0"},"reference-count":32,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,12,2]],"date-time":"2024-12-02T00:00:00Z","timestamp":1733097600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>A variable proportion of non\u2010responders to cardiac resynchronization therapy (CRT) warrants the search for new approaches to optimize the position of the left ventricular (LV) lead and the CRT device programming. CineECG is a novel ECG modality proposed for the spatial visualization and quantification of myocardial depolarization and repolarization sequences.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>The present study aimed to evaluate CineECG\u2010derived parameters in different pacing modes and to test their associations with acute hemodynamic responses in CRT patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and Results<\/jats:title><jats:p>CineECG was used to construct the average electrical path within the cardiac anatomy from the 12\u2010lead ECG. CineECG and LV dP\/dt max were tested in 15 patients with nonischemic dilated cardiomyopathy and left bundle branch block (QRS: 170\u2009\u00b1\u200917\u2009ms; LVEF: 26\u2009\u00b1\u20095.5%) under pacing protocols with different LV lead localizations. The CineECG\u2010derived path directions were computed for the QRS and ST\u2010T intervals for the anteroposterior (X<jats:sub>h<\/jats:sub>), interventricular (Y<jats:sub>h<\/jats:sub>), and apicobasal (Z<jats:sub>h<\/jats:sub>) axes. In a multivariate linear regression analysis with adjustment for the pacing protocol type, the ST\u2010T path direction Y<jats:sub>h<\/jats:sub> was independently associated with the increase in dP\/dt max during CRT, [regression coefficient 639.4 (95% confidence interval: 187.9\u20131090.9), <jats:italic>p<\/jats:italic>\u2009=\u20090.006]. In ROC curve analysis, the ST\u2010T path direction Y<jats:sub>h<\/jats:sub> was associated with the achievement of a 10% increase in dP\/dt max (AUC: 0.779, <jats:italic>p<\/jats:italic>\u2009=\u20090.002) with the optimal cut\u2010off &gt; 0.084 (left\u2010to\u2010right direction) with sensitivity 0.67 and specificity 0.92.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The acute hemodynamic response in CRT patients was associated with specific CineECG repolarization sequence parameters, warranting their further testing as potential predictors of clinical outcomes.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jce.16525","type":"journal-article","created":{"date-parts":[[2024,12,2]],"date-time":"2024-12-02T09:27:38Z","timestamp":1733131658000},"page":"338-346","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["CineECG Repolarization Gradients Predict Acute Hemodynamic Response in CRT Patients"],"prefix":"10.1111","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0723-2675","authenticated-orcid":false,"given":"Ksenia","family":"Sedova","sequence":"first","affiliation":[{"name":"Department of Biomedical Technology Faculty of Biomedical Engineering, Czech Technical University in Prague Kladno Czech Republic"},{"name":"Department of Cardiology Institute for Clinical and Experimental Medicine Prague Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1779-273X","authenticated-orcid":false,"given":"Jan E.","family":"Azarov","sequence":"additional","affiliation":[{"name":"Department of Biomedical Technology Faculty of Biomedical Engineering, Czech Technical University in Prague Kladno Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter M.","family":"Van Dam","sequence":"additional","affiliation":[{"name":"Center for Digital Medicine and Robotics Jagiellonian University Medical College Krakow Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucie","family":"Necasova","sequence":"additional","affiliation":[{"name":"Department of Cardiology Institute for Clinical and Experimental Medicine Prague Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan","family":"Kukla","sequence":"additional","affiliation":[{"name":"Department of Cardiology Institute for Clinical and Experimental Medicine Prague Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marek","family":"Sramko","sequence":"additional","affiliation":[{"name":"Department of Cardiology Institute for Clinical and Experimental Medicine Prague Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lukas","family":"Kryze","sequence":"additional","affiliation":[{"name":"Department of Cardiology Institute for Clinical and Experimental Medicine Prague Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Josef","family":"Kautzner","sequence":"additional","affiliation":[{"name":"Department of Cardiology Institute for Clinical and Experimental Medicine Prague Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,12,2]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehab364"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcdd10100428"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2015.07.012"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hroo.2020.03.003"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacep.2023.07.007"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2023.1054095"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2017.12.028"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/euab267"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/pace.14185"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/ehjopen\/oeac013"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2010.11.010"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jelectrocard.2012.09.001"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jelectrocard.2022.10.001"},{"key":"e_1_2_10_15_1","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.jelectrocard.2021.07.014","article-title":"The Relation of 12 Lead ECG to the Cardiac Anatomy: The Normal CineECG","volume":"69","author":"Dam P. 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