{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T15:08:58Z","timestamp":1787843338392,"version":"build-2784847793"},"reference-count":13,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,12,23]],"date-time":"2024-12-23T00:00:00Z","timestamp":1734912000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Cryoballoon ablation is less operator\u2010dependent than radiofrequency ablation. Recently, size\u2010adjustable cryoballoons (SA\u2010CBs) have become available. We sought to analyze the individual baseline operator experience's impact on procedural results.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This multicenter observational study included atrial fibrillation (AF) patients who underwent pulmonary vein (PV) isolation using SA\u2010CBs capable of 28\u2010mm or 31\u2010mm balloon sizes. Experienced (E\u2010group) or less experienced (LE\u2010group) operators were defined as experiencing &gt;\u2009100 or \u2264\u2009100 cryoballoon procedures, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 510 patients (67\u2009\u00b1\u200911 years, 355 men, 325 paroxysmal AF [PAF]) who underwent an SA\u2010CB ablation, 240 and 270 were in the E\u2010group and LE\u2010group, respectively. All cryoballoon parameters were similar between the groups, except for a significantly higher 31\u2010mm balloon isolation rate in the E\u2010group than LE\u2010group, especially for right superior PVs. Cryoballoon\u2010related phrenic nerve injury occurred in 34 (6.7%) patients and tended to be higher in the LE\u2010group than E\u2010group (8.1% vs. 5.0%, <jats:italic>p<\/jats:italic>\u2009=\u20090.16). The AF freedom was comparable between the groups for both PAF and non\u2010PAF patients. A total of 36(7.1%) patients underwent re\u2010do procedures at 5.2\u2009\u00b1\u20092.6 months post\u2010index procedure. The PV reconnection rate was significantly higher in the LE\u2010group than E\u2010group (27.1% vs. 8.9%, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01), and this trend was more pronounced for right PVs than left PVs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In AF ablation using SA\u2010CBs, the overall procedural efficacy and safety were comparable between the E\u2010group and LE\u2010group. However, 100 CB procedures seemed to still be in the middle of a learning curve for selecting the balloon size and balloon position, especially for right PVs.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jce.16526","type":"journal-article","created":{"date-parts":[[2024,12,24]],"date-time":"2024-12-24T05:34:41Z","timestamp":1735018481000},"page":"422-429","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Impact of the Individual Operator Experience and Learning Curve of a Novel Size Adjustable Cryoballoon"],"prefix":"10.1111","volume":"36","author":[{"given":"Yosuke","family":"Hayashi","sequence":"first","affiliation":[{"name":"Department of Cardiology Sakakibara Heart Institute Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0230-0934","authenticated-orcid":false,"given":"Shinsuke","family":"Miyazaki","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Institute of Science Tokyo Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junichi","family":"Nitta","sequence":"additional","affiliation":[{"name":"Department of Cardiology Sakakibara Heart Institute Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2179-3786","authenticated-orcid":false,"given":"Osamu","family":"Inaba","sequence":"additional","affiliation":[{"name":"Department of Cardiology Japanese Red Cross Saitama Hospital Saitama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuichiro","family":"Sagawa","sequence":"additional","affiliation":[{"name":"Department of Cardiology Japanese Red Cross Yokohama City Bay Hospital Kanagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7775-6429","authenticated-orcid":false,"given":"Shinsuke","family":"Iwai","sequence":"additional","affiliation":[{"name":"Department of Cardiology Hiratsuka Kyosai Hospital Kanagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukio","family":"Sekiguchi","sequence":"additional","affiliation":[{"name":"Department of Cardiology Sakakibara Heart Institute Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7027-2613","authenticated-orcid":false,"given":"Yukihiro","family":"Inamura","sequence":"additional","affiliation":[{"name":"Department of Cardiology Japanese Red Cross Saitama Hospital Saitama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4661-2999","authenticated-orcid":false,"given":"Yasuteru","family":"Yamauchi","sequence":"additional","affiliation":[{"name":"Department of Cardiology Japanese Red Cross Yokohama City Bay Hospital Kanagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kentaro","family":"Goto","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Institute of Science Tokyo Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takuro","family":"Nishimura","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Institute of Science Tokyo Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3582-6104","authenticated-orcid":false,"given":"Tetsuo","family":"Sasano","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Institute of Science Tokyo Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,12,23]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2017.05.012"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2015.03.021"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2029554"},{"issue":"1","key":"e_1_2_9_5_1","first-page":"48","article-title":"Results From a Multicentre Comparison of Cryoballoon vs. Radiofrequency Ablation for Paroxysmal Atrial Fibrillation: Is Cryoablation More Reproducible?","volume":"19","author":"Providencia R.","year":"2017","journal-title":"Europace"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/jce.14951"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/jce.14915"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10840-023-01645-2"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/jce.16220"},{"key":"e_1_2_9_10_1","article-title":"Novel Size Adjustable Cryoballoon Ablation Catheter for Atrial Fibrillation: Multicenter Experience of Over 500 Cases","author":"Hayashi Y.","journal-title":"JACC Clinical Electrophysiology"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.111.969923"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/euac148"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/euac100"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.121.010516"}],"container-title":["Journal of Cardiovascular Electrophysiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jce.16526","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T11:03:31Z","timestamp":1751454211000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jce.16526"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,23]]},"references-count":13,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,2]]}},"alternative-id":["10.1111\/jce.16526"],"URL":"https:\/\/doi.org\/10.1111\/jce.16526","archive":["Portico"],"relation":{},"ISSN":["1045-3873","1540-8167"],"issn-type":[{"value":"1045-3873","type":"print"},{"value":"1540-8167","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12,23]]},"assertion":[{"value":"2024-10-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-11-20","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-12-23","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}