{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,18]],"date-time":"2026-04-18T07:30:31Z","timestamp":1776497431089,"version":"3.51.2"},"reference-count":5,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,12,23]],"date-time":"2024-12-23T00:00:00Z","timestamp":1734912000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Idiopathic ventricular arrhythmias (VAs) arising from the left anterior fascicle (LAF) are uncommonly seen, and their characteristics still need to be sufficiently investigated. This study aimed to conclude these VAs' characteristics and explore efficient ablation strategies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Data were analyzed from 118 patients undergoing successful catheter ablation for LAF VAs. Patients were divided into three groups based on target sites in LAF: proximal\u2010LAF group (<jats:italic>n<\/jats:italic>\u2009=\u200930, from the common trunk of the left bundle branch to the LAF below the right coronary cusp (RCC), middle\u2010LAF group (<jats:italic>n<\/jats:italic>\u2009=\u200935, the LAF below the RCC and left coronary cusp (LCC), distal\u2010LAF group (<jats:italic>n<\/jats:italic>\u2009=\u200953, the LAF below LCC to the LAF terminal).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>From proximal\u2010 to distal\u2010LAF, VAs showed a gradually decreased Purkinje\u2010ventricular (PV) and His\u2010ventricular (HV) interval. For proximal\u2010LAF VAs, a distance from the sites recorded with the earliest Purkinje potential to RCC of 4.08\u2009\u00b1\u20091.03\u2009mm predicted successful ablation in RCC. There are significant differences among the three groups in QRS duration, R\/S ratio in V6, and Lead I. Using these three ECG characteristics as a panel to predict the origin of LAF VAs, the area under curve (AUC) was 0.96% and 95% confidence interval (CI) was 0.916\u20131.0 in the proximal\u2010 and middle\u2010LAF group, the AUC was 0.998 and 95% CI was 0.994\u20131.0 in the middle\u2010 and distal\u2010LAF group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>When LAF is anatomically divided into proximal, middle, and distal segments, QRS duration and R\/S ratio in Leads V6 and I are available to predict the origin and promote a successful catheter ablation. In addition, combining these three ECG characteristics as a panel can better facilitate the prediction of LAF\u2010VA origin.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jce.16549","type":"journal-article","created":{"date-parts":[[2024,12,24]],"date-time":"2024-12-24T05:45:23Z","timestamp":1735019123000},"page":"449-456","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Catheter Ablation of Idiopathic Left Anterior Fascicular Ventricular Arrhythmias: Predicting Origin Sites via Mapping and Electrocardiography"],"prefix":"10.1111","volume":"36","author":[{"given":"Zhi\u2010Xiang","family":"Zhou","sequence":"first","affiliation":[{"name":"Department of Cardiology Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University Wenzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wu\u2010Ming","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Cardiology Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University Wenzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jia\u2010Sheng","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Cardiology Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University Wenzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ze\u2010Chao","family":"Hong","sequence":"additional","affiliation":[{"name":"Department of Cardiology Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University Wenzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Cardiology Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University Wenzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Cardiology Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University Wenzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Cardiology Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University Wenzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jia\u2010Xuan","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Cardiology Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University Wenzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi\u2010Fan","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Cardiology Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University Wenzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucia","family":"D'Angelo","sequence":"additional","affiliation":[{"name":"Department of Cardiology Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University Wenzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shea Michaela","family":"James","sequence":"additional","affiliation":[{"name":"Department of Cardiology Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University Wenzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mei\u2010ling","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Cardiology Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University Wenzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1748-7794","authenticated-orcid":false,"given":"Jia\u2010Feng","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Cardiology Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University Wenzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6100-6671","authenticated-orcid":false,"given":"Cheng","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Cardiology Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University Wenzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,12,23]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1021100828459"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2015.12.003"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2014.06.024"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.117.005240"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.119.008173"}],"container-title":["Journal of Cardiovascular Electrophysiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jce.16549","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T11:03:29Z","timestamp":1751454209000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jce.16549"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,23]]},"references-count":5,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,2]]}},"alternative-id":["10.1111\/jce.16549"],"URL":"https:\/\/doi.org\/10.1111\/jce.16549","archive":["Portico"],"relation":{},"ISSN":["1045-3873","1540-8167"],"issn-type":[{"value":"1045-3873","type":"print"},{"value":"1540-8167","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12,23]]},"assertion":[{"value":"2024-08-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication 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