{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,17]],"date-time":"2025-12-17T13:06:52Z","timestamp":1765976812121,"version":"3.40.4"},"reference-count":10,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,1,27]],"date-time":"2025-01-27T00:00:00Z","timestamp":1737936000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004374","name":"Medtronic","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004374","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Freedom from recurrences of atrial tachyarrhythmia (ATA) is suboptimal after pulmonary vein isolation (PVI) in patients with persistent atrial fibrillation (PsAF). This sub\u2010analysis from the Cryo Global Registry sought to investigate predictors of ablation success after PVI using cryoballoon ablation (CBA) for PsAF.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and Results<\/jats:title><jats:p>ATA recurrence was defined as \u2265\u200930\u2009s recurrence of atrial fibrillation, atrial flutter or atrial tachycardia after a 90\u2010day blanking period and through 12\u2010months. Univariate and multivariable Cox regression analysis (with ATA recurrence as an endpoint) was performed to identify CBA responders. PsAF patients (<jats:italic>N<\/jats:italic>\u2009=\u2009882) were on average 63.9\u2009\u00b1\u200911.3 years old (69.2% male), and freedom from ATA recurrence was 79.7% (76.8%\u201382.2%). Longer elapsed time from PsAF diagnosis to ablation (hazard ratio [HR] 1.07 (95% confidence interval [CI]: 1.03\u20131.11); <jats:italic>p<\/jats:italic>\u2009=\u20090.002) and a larger number of previously failed antiarrhythmic drugs (HR 1.39 (95% CI: 1.13\u20131.70); <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.002) were shown to be independent predictors of ATA recurrence in a multivariate model which included 703 evaluated patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>These real\u2010world results provide important insights to guide referral of PsAF patients, including the benefits of earlier treatment via CBA.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jce.16571","type":"journal-article","created":{"date-parts":[[2025,1,27]],"date-time":"2025-01-27T14:03:18Z","timestamp":1737986598000},"page":"874-878","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Predictors of Arrhythmia Recurrence After Cryoballoon Ablation for Persistent Atrial Fibrillation: A Sub\u2010Analysis of the Cryo Global Registry"],"prefix":"10.1111","volume":"36","author":[{"given":"K. R. Julian","family":"Chun","sequence":"first","affiliation":[{"name":"Cardioangiologisches Centrum Bethanien Frankfurt Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christoph","family":"Stellbrink","sequence":"additional","affiliation":[{"name":"Universitat Bielefeld Medizinische Fakultat OWL Bielefeld Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masato","family":"Murakami","sequence":"additional","affiliation":[{"name":"Shonan Kamakura Sogo Byoin Nosocchu Shinryoka Kamakura Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Drephal","sequence":"additional","affiliation":[{"name":"Sana Klinikum Lichtenberg Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Il\u2010Young","family":"Oh","sequence":"additional","affiliation":[{"name":"Seoul National University Bundang Hospital Seongnam South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4118-4291","authenticated-orcid":false,"given":"Kelly A.","family":"van Bragt","sequence":"additional","affiliation":[{"name":"Medtronic Minneapolis MN United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8023-9246","authenticated-orcid":false,"given":"Daniel","family":"Becker","sequence":"additional","affiliation":[{"name":"Medtronic Minneapolis MN United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sylvain","family":"Anselme","sequence":"additional","affiliation":[{"name":"Medtronic France SAS Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Derick","family":"Todd","sequence":"additional","affiliation":[{"name":"Liverpool Heart and Chest Hospital NHS Foundation Trust Liverpool UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Krzysztof","family":"Kaczmarek","sequence":"additional","affiliation":[{"name":"Uniwersytet Medyczny w Lodzi Klinika Kardiologii \u0141\u00f3d\u017a Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junichi","family":"Nitta","sequence":"additional","affiliation":[{"name":"Sakakibara Kinen Byoin Fuchu Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,1,27]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacep.2018.07.007"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2020.06.020"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/joa3.12504"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.5603\/KP.a2016.0186"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/pace.14881"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10840-023-01636-3"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.92.7.1954"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000001193"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/jce.15002"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacep.2023.07.008"}],"container-title":["Journal of Cardiovascular Electrophysiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jce.16571","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,10]],"date-time":"2025-04-10T12:32:41Z","timestamp":1744288361000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jce.16571"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,27]]},"references-count":10,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,4]]}},"alternative-id":["10.1111\/jce.16571"],"URL":"https:\/\/doi.org\/10.1111\/jce.16571","archive":["Portico"],"relation":{},"ISSN":["1045-3873","1540-8167"],"issn-type":[{"type":"print","value":"1045-3873"},{"type":"electronic","value":"1540-8167"}],"subject":[],"published":{"date-parts":[[2025,1,27]]},"assertion":[{"value":"2024-09-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-12-31","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-01-27","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}