{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T16:06:47Z","timestamp":1791216407937,"version":"4.1.0"},"reference-count":29,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2025,4,2]],"date-time":"2025-04-02T00:00:00Z","timestamp":1743552000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,4,2]],"date-time":"2025-04-02T00:00:00Z","timestamp":1743552000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Real\u2010life data on efficacy and safety of pulsed\u2010field ablation (PFA) using the pentaspline multi\u2010electrode catheter in symptomatic atrial fibrillation (AF) patients is still scarce.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study aims to assess the efficacy and safety of PFA in patients with persistent AF.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Data from early commercial use across seven European centers were collected in a registry. To confirm the efficacy and safety of extra pulmonary vein (PV) ablation, patients were categorized into two groups: those undergoing pulmonary vein isolation (PVI) alone and those receiving additional ablation. Procedural and follow\u2010up data were collected.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The study included 448 patients (347 PVI only, 101 PVI +\n                      <jats:italic>\u03b1<\/jats:italic>\n                      ). In the PVI +\n                      <jats:italic>\u03b1<\/jats:italic>\n                      group, extra PV ablation included left atrial posterior wall isolation (87%), mitral isthmus ablation (37%), and cavo\u2010tricuspid isthmus ablation (3%). At 1\u2010year follow\u2010up, the PVI only group showed significantly fewer atrial tachyarrhythmia recurrences compared to PVI +\n                      <jats:italic>\u03b1<\/jats:italic>\n                      group (69% vs. 56%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.013). While AF recurrence did not significantly differ (25% vs. 28%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.713), PVI +\n                      <jats:italic>\u03b1<\/jats:italic>\n                      group had a significantly higher atrial tachycardia recurrence (8%\n                      <jats:italic>vs.<\/jats:italic>\n                      22%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Major complications occurred in 2.0% versus 1.0% (PVI only\n                      <jats:italic>vs.<\/jats:italic>\n                      PVI +\n                      <jats:italic>\u03b1<\/jats:italic>\n                      ), including pericardial tamponade (6 vs. 0;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.345) and stroke (1 vs. 1;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.400).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>PVI plus extra PV ablation using a pentaspline PFA catheter is associated with a higher incidence of atrial tachycardia recurrences. For persistent AF, a simpler approach of performing only PVI may be more effective.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jce.16583","type":"journal-article","created":{"date-parts":[[2025,4,4]],"date-time":"2025-04-04T04:17:21Z","timestamp":1743740241000},"page":"1710-1720","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Pulsed\u2010Field Ablation for Persistent Atrial Fibrillation in EU\u2010PORIA Registry"],"prefix":"10.1111","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5588-0533","authenticated-orcid":false,"given":"Jun","family":"Hirokami","sequence":"first","affiliation":[{"name":"Cardioangiologisches Centrum Bethanien Frankfurt Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2355-6015","authenticated-orcid":false,"given":"Kyoung Ryul 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Witten\/Herdecke University Witten Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7197-8415","authenticated-orcid":false,"given":"Tobias","family":"Reichlin","sequence":"additional","affiliation":[{"name":"Inselspital\u2014Bern University Hospital University of Bern Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuri","family":"Blaauw","sequence":"additional","affiliation":[{"name":"Department of Cardiology University of Groningen, University Medical Center Groningen Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6600-9006","authenticated-orcid":false,"given":"Jim","family":"Hansen","sequence":"additional","affiliation":[{"name":"Arrhythmia Unit, Department of Cardiology Gentofte Hospital Copenhagen 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