{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T19:57:59Z","timestamp":1776369479021,"version":"3.51.2"},"reference-count":43,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,2,10]],"date-time":"2025-02-10T00:00:00Z","timestamp":1739145600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The epidemiological landscape and treatment efficacy of atrial fibrillation (AF) in the Middle East, notably in the United Arab Emirates (UAE), remain under\u2010explored, presenting a distinct demographic and clinical pattern compared to Western populations. The FLOW\u2010AF Registry aimed to bridge this knowledge gap by examining the characteristics, treatment patterns, clinical outcomes, and healthcare resource utilization (HCRU) of newly diagnosed non\u2010valvular atrial fibrillation (NVAF) patients in the UAE, contributing to the scant literature on NVAF management in the region.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This multicenter, prospective observational study enrolled patients diagnosed with NVAF across six sites in the UAE. Data were collected on demographics, medical history, treatment decisions, clinical outcomes, and HCRU over a 12\u2010month observation period.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 198 patients were enrolled, with a mean age of 63.44 years. Mean CHA\u2082DS\u2082\u2010VASc and HAS\u2010BLED scores at baseline were 2.95 and 1.76, respectively. Most patients (55.77%) were prescribed non\u2010vitamin K antagonist oral anticoagulants (NOACs). One\u2010year incidence rates for major clinical events were 6.7% for all\u2010cause mortality, 2.8% for bleeding complications, and 0.6% for myocardial infarction. No strokes were reported during the study period.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The FLOW\u2010AF Registry provides valuable insights into NVAF management in the UAE, demonstrating a distinct patient profile and a preference for NOACs. The NVAF cohort in the UAE was characterized by a younger demographic with lower risk scores and lower rate of clinical events relative to global counterparts. The findings underscore the evolving approach to AF management in the UAE, suggestive of a shift towards NOAC use but also highlights the need for ongoing research to fully understand long\u2010term outcomes and validate current treatment paradigms in the UAE.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jce.16598","type":"journal-article","created":{"date-parts":[[2025,2,11]],"date-time":"2025-02-11T13:49:18Z","timestamp":1739281758000},"page":"813-823","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["The Atrial Fibrillation Registry (The FLOW\u2010AF Registry): Insights From the United Arab Emirates\u2014Patient Characteristics, Treatment, and One\u2010Year Outcomes"],"prefix":"10.1111","volume":"36","author":[{"given":"Moutaz","family":"El Kadri","sequence":"first","affiliation":[{"name":"Sheikh Khalifa Medical City Abu Dhabi United Arab Emirates"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Khalid","family":"AlMuti","sequence":"additional","affiliation":[{"name":"Cleveland Clinic Abu Dhabi Abu Dhabi United Arab Emirates"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amrish","family":"Agrawal","sequence":"additional","affiliation":[{"name":"Fujairah Hospital, EHS Fujairah United Arab Emirates"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nooshin","family":"Bazargani","sequence":"additional","affiliation":[{"name":"Dubai Hospital Dubai United Arab Emirates"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed Fathy Soliman","family":"Gamaleldin","sequence":"additional","affiliation":[{"name":"Pfizer Gulf Dubai United Arab Emirates"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2883-3317","authenticated-orcid":false,"given":"Haytham Mohamed","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Pfizer Gulf Dubai United Arab Emirates"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Omneya","family":"Hassanain","sequence":"additional","affiliation":[{"name":"IQVIA, Real\u2010World Evidence Dubai United Arab Emirates"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natasha","family":"Khalife","sequence":"additional","affiliation":[{"name":"IQVIA, Real\u2010World Evidence Dubai United Arab Emirates"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ghazi","family":"Radaideh","sequence":"additional","affiliation":[{"name":"Rashid Hospital Dubai United Arab Emirates"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed","family":"Magdy","sequence":"additional","affiliation":[{"name":"Al Qassimi Hospital Sharjah United Arab Emirates"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0312-9910","authenticated-orcid":false,"given":"Wael A.","family":"Almahmeed","sequence":"additional","affiliation":[{"name":"Cleveland Clinic Abu Dhabi Abu Dhabi United Arab Emirates"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,2,10]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/1747493019897870"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.311.7017.1425"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.15420\/usc.2007.4.1.14"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/euv309"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.2459\/JCM.0000000000000236"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)61682-2"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.2147\/CLEP.S47385"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12889-022-14403-2"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1080\/14779072.2018.1457953"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.2174\/1874220301906010033"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCOUTCOMES.110.958165"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.33590\/emjcardiol\/10310292"},{"key":"e_1_2_11_14_1","first-page":"17","article-title":"Health Care Resource Utilization and Costs in Individuals With Atrial Fibrillation in United Arab Emirates and Kingdom of Saudi Arabia: A Retrospective Cohort Study","volume":"4","author":"Johnston K. 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