{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T14:09:27Z","timestamp":1790431767130,"version":"4.1.0"},"reference-count":14,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,3,17]],"date-time":"2025-03-17T00:00:00Z","timestamp":1742169600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,3,17]],"date-time":"2025-03-17T00:00:00Z","timestamp":1742169600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100006479","name":"Cordis","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006479","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>While manual compression (MC) remains the standard of care to achieve hemostasis, a novel vascular closure device (VCD) was designed to achieve faster hemostasis without compromising safety. The objective of the ReliaSeal trial was to evaluate the safety and effectiveness of the Mynx Control Venous VCD to close a single or multiple femoral venous access sites in one or both limbs in patients undergoing catheter\u2010based procedures.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The ReliaSeal trial was a prospective, randomized controlled trial comparing VCD to MC in patients undergoing catheter\u2010based procedures requiring single or multiple access sites utilizing up to 12F sheaths. Endpoints included time to ambulation (TTA), time to hemostasis (TTH), time to discharge eligibility (TTDE), procedural\/device success, and 30\u2010day major and minor access site complications.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Two hundred and seventy subjects were randomized to the VCD or MC arm (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009177 vs.\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200993) with a mean age of 66.7\u2009\u00b1\u200911.27 years. TTA, TTH, and TTDE were significantly reduced in VCD subjects compared to MC (TTA: 2.6\u2009\u00b1\u20091.03 vs. 5.1\u2009\u00b1\u20094.35\u2009h,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001; TTH: 2.1\u2009\u00b1\u20091.79 vs. 11.4\u2009\u00b1\u20097.19\u2009min,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001; TTDE: 3.1\u2009\u00b1\u20091.24 vs. 5.5\u2009\u00b1\u20094.58\u2009h,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001, respectively). Procedural and device success was achieved in 100% of VCD subjects, compared to 98.9% of the MC group. No major or minor complications occurred in the VCD group; with a 5% minor complication rate in the MC group.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The use of VCD resulted in significant reductions in TTA, TTH, and TTDE, with no major or minor complications and a high success rate.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jce.16623","type":"journal-article","created":{"date-parts":[[2025,3,18]],"date-time":"2025-03-18T02:19:45Z","timestamp":1742264385000},"page":"1022-1031","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Safety and Efficacy of a Novel Sealant\u2010Based Vascular Closure Device Following Electrophysiology Procedures: ReliaSeal Trial"],"prefix":"10.1111","volume":"36","author":[{"given":"John","family":"Summers","sequence":"first","affiliation":[{"name":"South Oklahoma Heart Research Center Oklahoma City Oklahoma USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vijay","family":"Swarup","sequence":"additional","affiliation":[{"name":"Arizona Heart Rhythm Center Phoenix Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-0566-6919","authenticated-orcid":false,"given":"Ian","family":"Parker","sequence":"additional","affiliation":[{"name":"Oklahoma Heart Hospital South Oklahoma City Oklahoma USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Bumgarner","sequence":"additional","affiliation":[{"name":"NC Heart and Vascular Research Raleigh North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Brenyo","sequence":"additional","affiliation":[{"name":"Piedmont Medical Center &amp; OnSite Clinical Solutions Rock Hill South Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Layth","family":"Saleh","sequence":"additional","affiliation":[{"name":"St. Anthony's Hospital, Lakewood, and St. Anthony North Hospital Westminster Colorado USA"},{"name":"Colorado Heart and Vascular PC Lakewood Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saihari","family":"Sadanandan","sequence":"additional","affiliation":[{"name":"St. Joseph's Hospital and Tampa Cardiovascular Interventions and Research Tampa Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier","family":"Sanchez","sequence":"additional","affiliation":[{"name":"Medical City Dallas Heart Hospital Dallas Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Beasley","sequence":"additional","affiliation":[{"name":"Palm Vascular Centers Research Ft. Lauderdale Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1789-4712","authenticated-orcid":false,"given":"Sanjaya","family":"Gupta","sequence":"additional","affiliation":[{"name":"Saint Luke's Hospital of Kansas City Kansas City Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"other members of the ReliaSeal Study Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,3,17]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacep.2017.05.005"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/jce.13471"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10840-022-01255-4"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1253\/circj.CJ-17-1213"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jjcc.2020.01.012"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10840-021-00981-5"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacep.2022.02.016"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10840-024-01773-3"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacep.2019.08.013"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/jce.14828"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/euz004"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1177\/17085381211062745"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.a.33149"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00238-008-0265-8"}],"container-title":["Journal of Cardiovascular Electrophysiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jce.16623","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jce.16623","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jce.16623","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T10:06:06Z","timestamp":1772964366000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jce.16623"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,17]]},"references-count":14,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,5]]}},"alternative-id":["10.1111\/jce.16623"],"URL":"https:\/\/doi.org\/10.1111\/jce.16623","archive":["Portico"],"relation":{},"ISSN":["1045-3873","1540-8167"],"issn-type":[{"value":"1045-3873","type":"print"},{"value":"1540-8167","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,17]]},"assertion":[{"value":"2024-12-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-02-16","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-17","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}