{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T15:57:01Z","timestamp":1772985421779,"version":"3.50.1"},"reference-count":26,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,3,18]],"date-time":"2025-03-18T00:00:00Z","timestamp":1742256000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,3,18]],"date-time":"2025-03-18T00:00:00Z","timestamp":1742256000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Radiofrequency ablation is a cornerstone therapy for patients with ischemic cardiomyopathy (ICM) presenting with ventricular tachycardia (VT). In this context, ablation is typically performed endocardially as a first\u2010line approach. However, despite acute procedural success, the risk of recurrence remains high, potentially due to the presence of epicardial substrate. Several observational studies have suggested the potential benefits of a first\u2010line endo\u2010epicardial approach in decreasing recurrence. In this context, the EPIC\u2010VT trial was designed to compare endocardial\u2010only ablation versus combined endo\u2010epicardial ablation as a first\u2010line approach in ICM patients with VT.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      The EPIC\u2010VT trial is a prospective, multicenter, controlled, randomized, open\u2010label superiority trial with two parallel groups (endocardial\u2010only approach vs\n                      <jats:italic>.<\/jats:italic>\n                      combined endo\u2010epicardial approach) in a 1:1 ratio. The primary objective of this study is to demonstrate that a combined endo\u2010epicardial approach reduces the risk of VT recurrence compared to an endocardial approach alone in patients with ICM. Patients will be followed for 2 years after the procedure.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results and Conclusion<\/jats:title>\n                    <jats:p>To date, only retrospective studies have compared VA recurrences in patients with ICM, depending on whether ablation was performed using an endocardial or an endo\u2010epicardial approach, with conflicting results. A meta\u2010analysis suggested an advantage of the endo\u2010epicardial approach over the endocardial approach (odds ratio\u2009=\u20090.39 [95% CI: 0.18\u20130.83]). However, the level of evidence remains low, and no controlled randomized study has confirmed this hypothesis. If the EPIC\u2010VT study confirms the superiority of a first\u2010line endo\u2010epicardial approach, such strategy could become the preferred option for VT ablation in ICM, thereby reducing the risk of VA recurrence.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jce.16630","type":"journal-article","created":{"date-parts":[[2025,3,19]],"date-time":"2025-03-19T01:10:05Z","timestamp":1742346605000},"page":"1038-1045","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Endo\u2010Epicardial vs. Endocardial\u2010Only Catheter Ablation of Ventricular Tachycardia in Patients With Ischemic Cardiomyopathy: The EPIC\u2010VT Trial Design"],"prefix":"10.1111","volume":"36","author":[{"given":"Rapha\u00ebl P.","family":"Martins","sequence":"first","affiliation":[{"name":"Univ Rennes, CHU Rennes, INSERM Rennes 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