{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T15:57:08Z","timestamp":1772985428785,"version":"3.50.1"},"reference-count":21,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,3,19]],"date-time":"2025-03-19T00:00:00Z","timestamp":1742342400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,3,19]],"date-time":"2025-03-19T00:00:00Z","timestamp":1742342400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100008497","name":"Boston Scientific Corporation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008497","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Pulmonary vein isolation (PVI) using a cryoballoon is well\u2010established for the treatment of paroxysmal atrial fibrillation (PAF). Compared to other available technologies, the usage of a stable, low\u2010pressure cryoballoon (POLARx, Boston Scientific) has demonstrated lower nadir temperatures and longer thawing times. However, 1\u2010year efficacy and safety still needs to be proven. The aim of the POLAR ICE Study was to evaluate 1\u2010year efficacy and safety outcomes of cryoballoon ablation in patients with paroxysmal atrial fibrillation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>POLAR ICE, a prospective, non\u2010randomized, international, multicenter study to examine safety and efficacy of the novel cryoballoon for paroxysmal atrial fibrillation and de novo PVI, enrolled 399 patients across 19 centers, between August 2020 and May 2021, of which 11 were redo patients (previous treatment in the LA) and 10 were non\u2010PAF patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      This study treated 391 patients with the novel cryoballoon. After 12 months, freedom from atrial fibrillation could be demonstrated in 88.1% and freedom from any arrhythmia in 83.5%. Long\u2010term primary composite safety events occurred in four (1.0%) patients, including one (0.26%) death (9.5 months post\u2010index, cause unknown), one (0.26%) stroke, one (0.26%) myocardial infarction, and one (0.26%) persistent PNP (0.26%). AAD usage showed a significant decrease over the course of the study. Biophysical parameters nadir temperature (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.008) and thaw time (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.053) were predictive of 12\u2010month freedom from recurrence.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In this prospective, non\u2010randomized, international, multicenter study, isolation of the pulmonary veins using a stable, low pressure cryoballoon was highly effective and safe in patients treated for paroxysmal atrial fibrillation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jce.16645","type":"journal-article","created":{"date-parts":[[2025,3,20]],"date-time":"2025-03-20T00:34:58Z","timestamp":1742430898000},"page":"1046-1052","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["One\u2010Year Success Rates of a Stable, Low Pressure Cryoballoon for the Treatment of Paroxysmal Atrial Fibrillation: Results of the Prospective, International, Multicenter POLAR ICE Study"],"prefix":"10.1111","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5926-6696","authenticated-orcid":false,"given":"Armin","family":"Luik","sequence":"first","affiliation":[{"name":"Medizinische Klinik IV, St\u00e4dtisches Klinikum Karlsruhe gGmbH Karlsruhe Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ante","family":"Anic","sequence":"additional","affiliation":[{"name":"Klinicki Bolnicki Centar Split Spinciceva Split Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claire A.","family":"Martin","sequence":"additional","affiliation":[{"name":"Royal Papworth Hospital NHS Foundation Trust Cambridge UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0122-7130","authenticated-orcid":false,"given":"Roland R.","family":"Tilz","sequence":"additional","affiliation":[{"name":"S Department of Rhythmology University Heart Center and German Center for Cardiovascular Research DZHK, Partner Site Hamburg Kiel L\u00fcbeck L\u00fcbeck Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4520-2725","authenticated-orcid":false,"given":"S. C.","family":"Yap","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Thoraxcenter, Cardiovascular Institute Erasmus MC Rotterdam the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlo","family":"de Asmundis","sequence":"additional","affiliation":[{"name":"University Hospital UZ Brussels Brussels Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5769-4398","authenticated-orcid":false,"given":"Laure","family":"Champ\u2010Rigot","sequence":"additional","affiliation":[{"name":"University Hospital of Caen Caen France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2131-1110","authenticated-orcid":false,"given":"Saverio","family":"Iacopino","sequence":"additional","affiliation":[{"name":"Maria Cecilia Hospital Cotignola Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3037-8704","authenticated-orcid":false,"given":"Phillip","family":"Sommer","sequence":"additional","affiliation":[{"name":"Heart and Diabetes Center NRW Bad Oeynhausen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2021-5434","authenticated-orcid":false,"given":"Elizabeth M.","family":"Albrecht","sequence":"additional","affiliation":[{"name":"Boston Scientific Arden Hills USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan D.","family":"Raybuck","sequence":"additional","affiliation":[{"name":"Boston Scientific Arden Hills USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth","family":"Richards","sequence":"additional","affiliation":[{"name":"Boston Scientific Arden Hills USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nele","family":"Cielen","sequence":"additional","affiliation":[{"name":"Boston Scientific Arden Hills USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pascal","family":"Defaye","sequence":"additional","affiliation":[{"name":"Grenoble Alpes University Hospital Grenoble France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,3,19]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehaa612"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/euw080"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/jce.15861"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1602014"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2029980"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.123.063988"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hroo.2023.03.001"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2023.05.018"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/euac100"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10840-021-01063-2"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2012.11.064"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/euad286"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/jce.16220"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.121.010516"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/jce.15368"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.115.002734"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2022.814026"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10840-023-01645-2"},{"key":"e_1_2_8_20_1","first-page":"S178","article-title":"Clinical Application of a Novel 31mm Cryoballoon for Pulmonary Vien Isolation, Procedural Data From the FIT Arm of FROZEN AF","volume":"2023","author":"Su W. 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