{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T03:12:42Z","timestamp":1790478762493,"version":"4.1.0"},"reference-count":15,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,3,23]],"date-time":"2025-03-23T00:00:00Z","timestamp":1742688000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The use of an automated annotation algorithm based on the maximal negative derivative of the unipolar potential (\u2212dV\/dTmax) for local activation timing in the ablation of outflow tract (OT) ventricular premature contractions (VPCs) remains controversial.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate the spatial differences in the earliest activation sites (EASs) of OT\u2010VPCs identified by an automated annotation based on unipolar \u2212dV\/dTmax versus manual annotation using local bipolar potentials.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Seventy\u2010nine patients with frequent OT\u2010VPCs who underwent successful ablation were included. VPCs originated from the right ventricular OT (RVOT) free wall (<jats:italic>n<\/jats:italic>\u2009=\u200910), RVOT septum (<jats:italic>n<\/jats:italic>\u2009=\u200925), aortomitral continuity (AMC) (<jats:italic>n<\/jats:italic>\u2009=\u200919), and aortic sinus cusps (ASCs) (<jats:italic>n<\/jats:italic>\u2009=\u200925). The spatial distance between EASs identified by the two annotation methods was analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The spatial distance between EASs was significantly larger in ASC\u2010origin VPCs compared to non\u2010ASC\u2010origin VPCs (median: 11.9\u2009mm [IQR: 7.9\u201314.9] vs. 1.2\u2009mm [IQR: 0.0\u20133.3], <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). Among non\u2010ASC\u2010origin VPCs, the spatial difference was smallest in VPCs from the RVOT free wall (median: 0\u2009mm) and larger in those from the RVOT septum (median: 1.6\u2009mm) and AMC (median: 2.2\u2009mm).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The spatial discordance of EAS between unipolar and bipolar mapping varies by the VPC origin site. The discrepancy is particularly pronounced in ASC\u2010origin VPCs, emphasizing the need for careful interpretation of automated annotation algorithms to ensure accurate localization and effective ablation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jce.16647","type":"journal-article","created":{"date-parts":[[2025,3,24]],"date-time":"2025-03-24T09:21:59Z","timestamp":1742808119000},"page":"1213-1222","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Differences Between the Unipolar Versus Bipolar Potential\u2010Based Activation Maps of Ventricular Premature Contractions Arising From Ventricular Outflow Tracts"],"prefix":"10.1111","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5287-8259","authenticated-orcid":false,"given":"Yoshimori J.","family":"An","sequence":"first","affiliation":[{"name":"Cardiac Electrophysiology Section, Department of Cardiovascular Medicine Cleveland Clinic Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masafumi","family":"Sugawara","sequence":"additional","affiliation":[{"name":"Cardiac Electrophysiology Section, Department of Cardiovascular Medicine Cleveland Clinic Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jakub","family":"Sroubek","sequence":"additional","affiliation":[{"name":"Cardiac Electrophysiology Section, Department of Cardiovascular Medicine Cleveland Clinic Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7269-9808","authenticated-orcid":false,"given":"Katsuhide","family":"Hayashi","sequence":"additional","affiliation":[{"name":"Cardiac Electrophysiology Section, Department of Cardiovascular Medicine Cleveland Clinic Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9943-3556","authenticated-orcid":false,"given":"John O.","family":"Lopez","sequence":"additional","affiliation":[{"name":"Cardiac Electrophysiology Section, Department of Cardiovascular Medicine Cleveland Clinic Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justin","family":"Lee","sequence":"additional","affiliation":[{"name":"Cardiac Electrophysiology Section, Department of Cardiovascular Medicine Cleveland Clinic Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4495-3845","authenticated-orcid":false,"given":"Shady","family":"Nakhla","sequence":"additional","affiliation":[{"name":"Cardiac Electrophysiology Section, Department of Cardiovascular Medicine Cleveland Clinic Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0023-9666","authenticated-orcid":false,"given":"Pasquale","family":"Santangeli","sequence":"additional","affiliation":[{"name":"Cardiac Electrophysiology Section, Department of Cardiovascular Medicine Cleveland Clinic Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oussama M.","family":"Wazni","sequence":"additional","affiliation":[{"name":"Cardiac Electrophysiology Section, Department of Cardiovascular Medicine Cleveland Clinic Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9218-1966","authenticated-orcid":false,"given":"Koji","family":"Higuchi","sequence":"additional","affiliation":[{"name":"Cardiac Electrophysiology Section, Department of Cardiovascular Medicine Cleveland Clinic Cleveland Ohio 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