{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T20:18:49Z","timestamp":1790885929466,"version":"4.1.0"},"reference-count":34,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,4,18]],"date-time":"2025-04-18T00:00:00Z","timestamp":1744934400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>High\u2010frequency low\u2010tidal\u2010volume (HFLTV) ventilation is a safe and cost\u2010effective strategy that improves catheter stability, first\u2010pass pulmonary vein isolation, and freedom from all\u2010atrial arrhythmias during radiofrequency catheter ablation (RFCA) of paroxysmal and persistent atrial fibrillation (AF). However, the incremental value of adding rapid\u2010atrial pacing (RAP) to HFLTV\u2010ventilation has not yet been determined.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To evaluate the effect of HFLTV\u2010ventilation plus RAP during RFCA of paroxysmal AF on procedural and long\u2010term clinical outcomes compared to HFLTV\u2010ventilation alone.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Patients from the REAL\u2010AF prospective multicenter registry, who underwent RFCA of paroxysmal AF using either HFLTV\u2009+\u2009RAP (500\u2013600\u2009msec) or HFLTV ventilation alone from April 2020 to February 2023 were included. The primary outcome was freedom from all\u2010atrial arrhythmias at 12\u2010month follow\u2010up. Secondary outcomes included procedural characteristics, long\u2010term clinical outcomes, and procedure\u2010related complications.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 545 patients were included in the analysis (HFLTV\u2009+\u2009RAP\u2009=\u2009327 vs. HFLTV\u2009=\u2009218). There were no significant differences in baseline characteristics between the groups. No differences were observed in procedural (HFLTV\u2009+\u2009RAP 74 [57\u201398] vs. HFLTV 66 [53\u201385.75] min,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.617) and RF (HFLTV\u2009+\u2009RAP 15.15 [11.22\u201321.22] vs. HFLTV 13.99 [11.04\u201317.13] min,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.620) times. Both groups showed a similar freedom from all\u2010atrial arrhythmias at 12\u2010month follow\u2010up (HFLTV\u2009+\u2009RAP 82.68% vs. HFLTV 86.52%, HR\u2009=\u20091.43, 95% CI [0.94\u20132.16],\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.093). There were no significant differences in freedom from AF\u2010related symptoms (HFLTV\u2009+\u2009RAP 91.4% vs. HFLTV 93.1%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.476) or AF\u2010related hospitalizations (HFLTV\u2009+\u2009RAP 98.5% vs. HFLTV 97.2%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.320). Procedure\u2010related complications were low in both groups (HFLTV\u2009+\u2009RAP 0.6% vs. HFLTV 0%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.247).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In patients undergoing RFCA for paroxysmal AF, adding RAP to HFLTV\u2010ventilation was not associated with improved procedural and long\u2010term clinical outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jce.16661","type":"journal-article","created":{"date-parts":[[2025,4,18]],"date-time":"2025-04-18T10:21:36Z","timestamp":1744971696000},"page":"1461-1471","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Procedural and Clinical Outcomes of High\u2010Frequency Low\u2010Tidal Volume Ventilation Plus Rapid\u2010Atrial Pacing in Paroxysmal Atrial Fibrillation Ablation"],"prefix":"10.1111","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3681-2321","authenticated-orcid":false,"given":"Paul C.","family":"Zei","sequence":"first","affiliation":[{"name":"Harvard Medical School, Division of Cardiovascular Medicine, Cardiac Arrhythmia Service Brigham and Women's Hospital Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0370-5618","authenticated-orcid":false,"given":"Daniela","family":"Hincapie","sequence":"additional","affiliation":[{"name":"Harvard Medical School, Division of Cardiovascular Medicine, Cardiac Arrhythmia Service Brigham and Women's Hospital Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joan","family":"Rodriguez\u2010Taveras","sequence":"additional","affiliation":[{"name":"Department of Medicine Boston Medical Center &amp; Boston University Chobanian &amp; Avedisian School of Medicine Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose","family":"Osorio","sequence":"additional","affiliation":[{"name":"HCA Florida Miami Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5417-9777","authenticated-orcid":false,"given":"Isabella","family":"Alviz","sequence":"additional","affiliation":[{"name":"Harvard Medical School, Division of Cardiovascular Medicine, Cardiac Arrhythmia Service Brigham and Women's Hospital Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andres F.","family":"Miranda\u2010Arboleda","sequence":"additional","affiliation":[{"name":"Harvard Medical School, Division of Cardiovascular Medicine, Cardiac Arrhythmia Service Brigham and Women's Hospital Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed","family":"Gabr","sequence":"additional","affiliation":[{"name":"Harvard Medical School, Division of Cardiovascular Medicine, Cardiac Arrhythmia Service Brigham and Women's Hospital Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Thorne","sequence":"additional","affiliation":[{"name":"Heart Rhythm Clinical Research Solutions Birmingham Alabama USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua R.","family":"Silverstein","sequence":"additional","affiliation":[{"name":"Allegheny Health Network Baden Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amit J.","family":"Thosani","sequence":"additional","affiliation":[{"name":"Allegheny Health Network Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allyson L.","family":"Varley","sequence":"additional","affiliation":[{"name":"Heart Rhythm Clinical Research Solutions Birmingham Alabama USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando","family":"Moreno","sequence":"additional","affiliation":[{"name":"Harvard Medical School, Division of Cardiovascular Medicine, Cardiac Arrhythmia Service Brigham and Women's Hospital Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-5512-475X","authenticated-orcid":false,"given":"Daniel A.","family":"Zapata","sequence":"additional","affiliation":[{"name":"Harvard Medical School, Division of Cardiovascular Medicine, Cardiac Arrhythmia Service Brigham and Women's Hospital Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"D'Souza","sequence":"additional","affiliation":[{"name":"Perelman School of Medicine at the University of Pennsylvania Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7607-1479","authenticated-orcid":false,"given":"Anil","family":"Rajendra","sequence":"additional","affiliation":[{"name":"Arrhythmia Institute Grandview Medical Group Birmingham Alabama USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saumil","family":"Oza","sequence":"additional","affiliation":[{"name":"Ascension Medical Group St Vincent's Cardiology Jacksonville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. N.","family":"Linda Justice","sequence":"additional","affiliation":[{"name":"Heart Rhythm Clinical Research Solutions Birmingham Alabama USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Baranowski","sequence":"additional","affiliation":[{"name":"Heart Rhythm Clinical Research Solutions Birmingham Alabama USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huy","family":"Phan","sequence":"additional","affiliation":[{"name":"Valley Heart Rhythm Specialists, PLLC Chandler Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandro","family":"Velasco","sequence":"additional","affiliation":[{"name":"University of Texas Health San Antonio San Antonio Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles C.","family":"Te","sequence":"additional","affiliation":[{"name":"Oklahoma Heart Hospital Oklahoma City Oklahoma USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew C.","family":"Sackett","sequence":"additional","affiliation":[{"name":"Centra Heart and Vascular Institute Lynchburg Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7266-0951","authenticated-orcid":false,"given":"Matthew J.","family":"Singleton","sequence":"additional","affiliation":[{"name":"WellSpan Health York Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony R.","family":"Magnano","sequence":"additional","affiliation":[{"name":"Ascension Medical Group St Vincent's Cardiology Jacksonville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Singh","sequence":"additional","affiliation":[{"name":"Queen's Heart Institute Honolulu Hawaii USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Kuk","sequence":"additional","affiliation":[{"name":"Centra Heart and Vascular Institute Lynchburg Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathaniel A.","family":"Steiger","sequence":"additional","affiliation":[{"name":"Harvard Medical School, Division of Cardiovascular Medicine, Cardiac Arrhythmia Service Brigham and Women's Hospital Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7070-0307","authenticated-orcid":false,"given":"William H.","family":"Sauer","sequence":"additional","affiliation":[{"name":"Harvard Medical School, Division of Cardiovascular Medicine, Cardiac Arrhythmia Service Brigham and Women's Hospital Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6420-8669","authenticated-orcid":false,"given":"Jorge E.","family":"Romero","sequence":"additional","affiliation":[{"name":"Harvard Medical School, Division of Cardiovascular Medicine, Cardiac Arrhythmia Service Brigham and Women's Hospital Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,4,18]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)61774-8"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.120.316340"},{"issue":"149","key":"e_1_2_9_4_1","first-page":"e1","article-title":"ACC\/AHA\/ACCP\/HRS Guideline for the Diagnosis and Management of Atrial Fibrillation: A Report of the American College of Cardiology\/American Heart Association Joint Committee on Clinical Practice Guidelines","volume":"2024","author":"Joglar J. A.","year":"2023","journal-title":"Circulation"},{"issue":"24","key":"e_1_2_9_5_1","first-page":"00261","article-title":"European Heart Rhythm Association (EHRA)\/Heart Rhythm Society (HRS)\/Asia Pacific Heart Rhythm Society (APHRS)\/Latin American Heart Rhythm Society (LAHRS) Expert Consensus Statement on Catheter and Surgical Ablation of Atrial Fibrillation","volume":"1547","author":"Tzeis S.","year":"2024","journal-title":"Heart Rhythm: The Official Journal of the Heart Rhythm Society"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.293.21.2634"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2014.467"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2009.2029"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.108.772582"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/eht457"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.119.007414"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.120.009573"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.120.008480"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/euad244"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacep.2022.12.020"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2014.04.072"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2012.07.016"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2014.07.033"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2012.02.015"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00380-017-0961-z"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2010.10.043"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/jce.14507"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacep.2018.08.016"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.121.010722"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacep.2023.05.015"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2024.07.094"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacep.2017.12.017"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10840-021-01031-w"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacep.2023.08.005"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.4022\/jafib.2097"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10840-022-01205-0"},{"issue":"24","key":"e_1_2_9_32_1","article-title":"Severe Periprocedural Complications After Ablation for Atrial Fibrillation: An International Collaborative Individual Patient Data Registry","volume":"2405","author":"Du Fay de Lavallaz J.","year":"2024","journal-title":"JACC Clinical Electrophysiology"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2007.01.016"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacep.2020.09.027"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2005.09.013"}],"container-title":["Journal of Cardiovascular Electrophysiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jce.16661","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,16]],"date-time":"2025-07-16T04:35:13Z","timestamp":1752640513000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jce.16661"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,18]]},"references-count":34,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2025,7]]}},"alternative-id":["10.1111\/jce.16661"],"URL":"https:\/\/doi.org\/10.1111\/jce.16661","archive":["Portico"],"relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2024.08.12.24311903","asserted-by":"object"}]},"ISSN":["1045-3873","1540-8167"],"issn-type":[{"value":"1045-3873","type":"print"},{"value":"1540-8167","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4,18]]},"assertion":[{"value":"2024-10-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-16","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-04-18","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}