{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T20:50:40Z","timestamp":1779310240218,"version":"3.51.4"},"reference-count":16,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,4,7]],"date-time":"2025-04-07T00:00:00Z","timestamp":1743984000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Approximately 10% of heart transplant (HT) recipients require a pacemaker (PM) implant. Despite graft\u2010related complications such as rejection, cardiac allograft vasculopathy and fibrosis, there is no evidence on the long\u2010term stability of pacing indices. Moreover, one of the most common indications for PM implant is early post\u2010transplant sinus node dysfunction (SND), although this is reversible in many cases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and Results<\/jats:title><jats:p>A retrospective observational study including all HT recipients at our institution who underwent permanent PM implantation between April 1991 and January 2023 was conducted. The incidence of PM implantation, indications for PM implantation and changes in pacing indices were evaluated. A total of 861 adult HT were performed (92.1% using bicaval anastomosis technique), and 46 received a permanent pacemaker (cumulative incidence 5.3%) over a median follow\u2010up of 7.9 years (IQR 2.5\u201315.1 years). Only one patient (2%) received a PM due to early post\u2010HT SND. The median PM follow\u2010up time was 5.4 years (IQR 2.0\u20138.1 years). Atrial and ventricular leads showed an initial impedance drop (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001 both) and an initial capture threshold increase (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001 and <jats:italic>p<\/jats:italic>\u2009=\u20090.003, respectively) with subsequent stabilization. R\u2010wave amplitude remained stable, but there was a drop in P\u2010wave amplitude (<jats:italic>p<\/jats:italic>\u2009=\u20090.026).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Pacing indices remained stable and showed a behavior similar to that of native hearts except for a progressive decrease in P\u2010wave amplitude, suggesting the need to aim for the highest possible P\u2010wave amplitude during implantation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jce.16671","type":"journal-article","created":{"date-parts":[[2025,4,7]],"date-time":"2025-04-07T07:06:16Z","timestamp":1744009576000},"page":"1336-1343","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Pacemaker Indications and Long\u2010Term Stability of Pacing Indices in Heart Transplant Recipients"],"prefix":"10.1111","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2676-8507","authenticated-orcid":false,"given":"Pablo Fern\u00e1ndez","family":"de\u2010Aspe","sequence":"first","affiliation":[{"name":"Department of Cardiology Complexo Hospitalario Universitario A Coru\u00f1a (CHUAC), A Coru\u00f1a  Galicia Spain"},{"name":"Instituto de Investigaci\u00f3n Biom\u00e9dica de A Coru\u00f1a (INIBIC), A Coru\u00f1a, Galicia  Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4384-222X","authenticated-orcid":false,"given":"Raquel","family":"V\u00e1zquez\u2010Garc\u00eda","sequence":"additional","affiliation":[{"name":"Department of Cardiology Complexo Hospitalario Universitario A Coru\u00f1a (CHUAC), A Coru\u00f1a  Galicia Spain"},{"name":"Instituto de Investigaci\u00f3n Biom\u00e9dica de A Coru\u00f1a (INIBIC), A Coru\u00f1a, Galicia  Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2599-799X","authenticated-orcid":false,"given":"Alejandro","family":"Used\u2010Gav\u00edn","sequence":"additional","affiliation":[{"name":"Department of Cardiology Complexo Hospitalario Universitario A Coru\u00f1a (CHUAC), A Coru\u00f1a  Galicia Spain"},{"name":"Instituto de Investigaci\u00f3n Biom\u00e9dica de A Coru\u00f1a (INIBIC), A Coru\u00f1a, Galicia  Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2632-0507","authenticated-orcid":false,"given":"Jorge L.","family":"Rodr\u00edguez\u2010Garrido","sequence":"additional","affiliation":[{"name":"Department of Cardiology Complexo Hospitalario Universitario A Coru\u00f1a (CHUAC), A Coru\u00f1a  Galicia Spain"},{"name":"Instituto de Investigaci\u00f3n Biom\u00e9dica de A Coru\u00f1a (INIBIC), A Coru\u00f1a, Galicia  Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0236-8111","authenticated-orcid":false,"given":"Ignacio","family":"Mosquera\u2010P\u00e9rez","sequence":"additional","affiliation":[{"name":"Department of Cardiology Complexo Hospitalario Universitario A Coru\u00f1a (CHUAC), A Coru\u00f1a  Galicia Spain"},{"name":"Instituto de Investigaci\u00f3n Biom\u00e9dica de A Coru\u00f1a (INIBIC), A Coru\u00f1a, Galicia  Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Cardiovasculares (CIBERCV), Instituto de Salud Carlos III Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda J.","family":"Paniagua\u2010Mart\u00edn","sequence":"additional","affiliation":[{"name":"Department of Cardiology Complexo Hospitalario Universitario A Coru\u00f1a (CHUAC), A Coru\u00f1a  Galicia Spain"},{"name":"Instituto de Investigaci\u00f3n Biom\u00e9dica de A Coru\u00f1a (INIBIC), A Coru\u00f1a, Galicia  Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Cardiovasculares (CIBERCV), Instituto de Salud Carlos III Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2572-2048","authenticated-orcid":false,"given":"Eduardo","family":"Barge\u2010Caballero","sequence":"additional","affiliation":[{"name":"Department of Cardiology Complexo Hospitalario Universitario A Coru\u00f1a (CHUAC), A Coru\u00f1a  Galicia Spain"},{"name":"Instituto de Investigaci\u00f3n Biom\u00e9dica de A Coru\u00f1a (INIBIC), A Coru\u00f1a, Galicia  Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Cardiovasculares (CIBERCV), Instituto de Salud Carlos III Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5662-5323","authenticated-orcid":false,"given":"Gonzalo","family":"Barge\u2010Caballero","sequence":"additional","affiliation":[{"name":"Department of Cardiology Complexo Hospitalario Universitario A Coru\u00f1a (CHUAC), A Coru\u00f1a  Galicia Spain"},{"name":"Instituto de Investigaci\u00f3n Biom\u00e9dica de A Coru\u00f1a (INIBIC), A Coru\u00f1a, Galicia  Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Cardiovasculares (CIBERCV), Instituto de Salud Carlos III Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1112-4063","authenticated-orcid":false,"given":"David","family":"Couto\u2010Mall\u00f3n","sequence":"additional","affiliation":[{"name":"Department of Cardiology Complexo Hospitalario Universitario A Coru\u00f1a (CHUAC), A Coru\u00f1a  Galicia Spain"},{"name":"Instituto de Investigaci\u00f3n Biom\u00e9dica de A Coru\u00f1a (INIBIC), A Coru\u00f1a, Galicia  Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Cardiovasculares (CIBERCV), Instituto de Salud Carlos III Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3989-8746","authenticated-orcid":false,"given":"Daniel","family":"Enr\u00edquez\u2010V\u00e1zquez","sequence":"additional","affiliation":[{"name":"Department of Cardiology Complexo Hospitalario Universitario A Coru\u00f1a (CHUAC), A Coru\u00f1a  Galicia Spain"},{"name":"Instituto de Investigaci\u00f3n Biom\u00e9dica de A Coru\u00f1a (INIBIC), A Coru\u00f1a, Galicia  Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Cardiovasculares (CIBERCV), Instituto de Salud Carlos III Madrid 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R.","year":"2017","journal-title":"Ochsner journal"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehab364"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10840-017-0226-x"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8159.1986.tb05408.x"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacep.2023.05.020"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.1102"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2011.08.003"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/eht511"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2011.12.014"}],"container-title":["Journal of Cardiovascular Electrophysiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jce.16671","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,12]],"date-time":"2025-06-12T12:47:41Z","timestamp":1749732461000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jce.16671"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,7]]},"references-count":16,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,6]]}},"alternative-id":["10.1111\/jce.16671"],"URL":"https:\/\/doi.org\/10.1111\/jce.16671","archive":["Portico"],"relation":{},"ISSN":["1045-3873","1540-8167"],"issn-type":[{"value":"1045-3873","type":"print"},{"value":"1540-8167","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4,7]]},"assertion":[{"value":"2024-12-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-24","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-04-07","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}