{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T21:44:22Z","timestamp":1789422262239,"version":"build-2803163510"},"reference-count":30,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,4,10]],"date-time":"2025-04-10T00:00:00Z","timestamp":1744243200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Despite leadless pacemakers (LPMs) showing promise, real\u2010world data comparing them to transvenous pacemakers (TV\u2010VVI) are insufficient and often contradictory, especially in patients without major comorbidities like heart failure.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Comparing LPMs with TV\u2010VVIs in real\u2010world patients without HF.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The TriNetX database (Jan 2015\u2013June 2023) was queried to include adults receiving their first single\u2010chamber ventricular pacemaker for heart block, bradycardia, sick sinus syndrome, atrial fibrillation, or syncope, excluding those with prior pacemakers, heart failure or enrolled for research settings. Propensity score matching (PSM) was done on 90 covariates. Primary outcomes were assessed after 1 week, 6 months, and 12 months and included mechanical complications, need for re\u2010intervention, cardiac\u2010related hemodynamic instability (CRHI), hospitalizations, and mortality. The risk ratio (RR) with a 95% confidence interval (CI) was reported. An E\u2010sensitivity analysis assessed the impact of unmeasured confounders.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Each group had 1,158 patients after PSM; 58.4% versus 58.9% were males, with mean ages of 74.9 versus 77.4 years. LPMs showed lower mechanical complications at all follow\u2010up points (RR 0.16, 0.18, 0.21,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.0001). CRHI was lower in the LPM group at 1 week and 6 months (RR 0.72, 0.85,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05) but higher mortality at 6 and 12 months (RR 1.436, 1.314,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). Hospitalization rates and re\u2010intervention rates were comparable between both groups. The E\u2010value was satisfactory.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In the absence of HF, LPM was associated with fewer rates of mechanical complications and CRHI. However, late mortality was higher with LPMs. Randomized trials comparing the two devices are crucial.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jce.16672","type":"journal-article","created":{"date-parts":[[2025,4,11]],"date-time":"2025-04-11T00:32:42Z","timestamp":1744331562000},"page":"1362-1376","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Comparative Analysis of Leadless Versus Transvenous Pacemakers in Non\u2010Heart Failure Patients: A Multicenter US Retrospective Study"],"prefix":"10.1111","volume":"36","author":[{"given":"Michele","family":"Fouad","sequence":"first","affiliation":[{"name":"Faculty of Medicine Alexandria University Alexandria Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kerollos","family":"Abdelsayed","sequence":"additional","affiliation":[{"name":"Heart Rhythm Science Center, Minneapolis Heart Institute Foundation Minneapolis Minnesota 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