{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T08:45:44Z","timestamp":1772613944956,"version":"3.50.1"},"reference-count":44,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,4,28]],"date-time":"2025-04-28T00:00:00Z","timestamp":1745798400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Catheter ablation of atrial fibrillation (AF) is an established treatment; however, recurrence remains a major issue.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This study included 606 patients with AF who underwent catheter ablation in Hiroshima University Hospital, including 143 and 463 patients with and without AF recurrence within 3 years after ablation, respectively. A logistic regression analysis and genome\u2010wide association study (GWAS) were conducted to identify the clinical and genetic factors, respectively, associated with the AF recurrence risk.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A logistic regression analysis revealed persistent AF, nonpulmonary vein AF triggers, the N\u2010terminal pro\u2010brain natriuretic peptide level, and the left atrial volume before catheter ablation were significant factors for recurrence (false discovery rate\u2009&lt;\u20090.05). Additionally, six variants (rs2106865, rs12577119, rs12574466, rs4902609, rs8027532, and rs2032303) were associated with the AF recurrence risk, based on the GWAS results' suggestive significance (<jats:italic>p<\/jats:italic>\u2009&lt;\u20095\u2009\u00d7\u200910<jats:sup>\u22126<\/jats:sup>). An expression quantitative trait locus analysis revealed a significant association between rs2106865 and ATP\u2010binding cassette subfamily C member 8 (<jats:italic>ABCC8<\/jats:italic>) expression in heart tissues (atrial appendage and left ventricle). A linear regression analysis demonstrated a significant association between the <jats:italic>ABCC8<\/jats:italic> variant rs2106865 and left atrium volume before ablation. Finally, the Cox proportional hazard model showed a significant association between the <jats:italic>ABCC8<\/jats:italic> variant and AF recurrence (<jats:italic>p<\/jats:italic>\u2009=\u20091.30\u2009\u00d7\u200910<jats:sup>\u22125<\/jats:sup> by log\u2010rank test; hazard ratio 1.74, 95% confidence interval 1.38\u20132.20).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our findings, which highlight both the clinical and genetic factors associated with AF recurrence in Japanese patients, may contribute to future efforts to improve treatment strategies for AF.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jce.16674","type":"journal-article","created":{"date-parts":[[2025,4,29]],"date-time":"2025-04-29T00:30:29Z","timestamp":1745886629000},"page":"1494-1503","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Genome\u2010Wide Association Study of Atrial Fibrillation Recurrence After Radiofrequency 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