{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,12]],"date-time":"2025-06-12T13:10:05Z","timestamp":1749733805191,"version":"3.41.0"},"reference-count":10,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,4,9]],"date-time":"2025-04-09T00:00:00Z","timestamp":1744156800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Sotalol is used for the maintenance of sinus rhythm among patients with atrial fibrillation. However, there is discretion regarding dosing of chronic therapy, and the target oral dose dictates infusion doses for intravenous sotalol loading. To date, use and outcomes by dose are not well\u2010described.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In the Prospective Evaluation Analysis and Kinetics of IV Sotalol (PEAKS) Registry, we analyzed outcomes among patients undergoing elective IV sotalol load for atrial arrhythmias (AT\/AF). Baseline characteristics, changes in ECG parameters, in\u2010hospital adverse events, and arrhythmia outcomes were compared based on target oral dose (80\u2009mg vs. 120\u2009mg).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 163 total patients, 85 (52%) of patients underwent loading anticipating target oral dose of 80\u2009mg, compared with 78 (48%) for 120\u2009mg. Those targeting 80\u2009mg were older (median age 70 vs. 66, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), with similar proportion female (24% vs. 21%, <jats:italic>p<\/jats:italic>\u2009=\u20090.71), and without significant differences in comorbidities or renal function. Patients targeted for 80\u2009mg were less frequently kept in\u2010hospital for 2 oral doses after intravenous infusion (45% vs. 89%, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). There were no significant differences in rates of sinus rhythm or adverse events during loading.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Selection of target oral sotalol dose (120 vs. 80\u2009mg) does not appear to be driven by patient characteristics, and may represent an opportunity for improved treatment. In\u2010hospital adverse events are low overall without differences between dose.<\/jats:p><\/jats:sec><jats:sec><jats:title>Trial Registration<\/jats:title><jats:p>Clinicaltrials. gov # NCT05247320.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jce.16677","type":"journal-article","created":{"date-parts":[[2025,4,10]],"date-time":"2025-04-10T06:19:01Z","timestamp":1744265941000},"page":"1352-1358","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Sotalol Dosing and Outcomes Among Patients Undergoing Intravenous Loading for Atrial Arrhythmias\u2014A PEAKS Registry Substudy"],"prefix":"10.1111","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4729-7820","authenticated-orcid":false,"given":"Benjamin A.","family":"Steinberg","sequence":"first","affiliation":[{"name":"Department of Medicine, Denver Health Medical Center Denver Colorado USA"},{"name":"Department of Medicine University of Colorado Anschutz Medical Campus Aroura Colorado USA"},{"name":"CPC Clinical Research Aurora Colorado USA"},{"name":"Department of Medicine University of Utah Health Sciences Center Salt Lake City Utah USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard","family":"Holubkov","sequence":"additional","affiliation":[{"name":"Data Coordinating Center, Department of Pediatrics University of Utah Health Sciences Center Salt Lake City Utah USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5349-0136","authenticated-orcid":false,"given":"T. Jared","family":"Bunch","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Utah Health Sciences Center Salt Lake City Utah USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas F.","family":"Deering","sequence":"additional","affiliation":[{"name":"Piedmont Heart Institute Atlanta Georgia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher A.","family":"Groh","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Utah Health Sciences Center Salt Lake City Utah USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Kennedy","sequence":"additional","affiliation":[{"name":"Munson Healthcare Traverse City Michigan USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2746-0202","authenticated-orcid":false,"given":"Marco","family":"Perez","sequence":"additional","affiliation":[{"name":"Stanford University Palo Alto California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0772-2404","authenticated-orcid":false,"given":"Jonathan P.","family":"Piccini","sequence":"additional","affiliation":[{"name":"Duke University Medical Center and the Duke Clinical Research Institute Durham North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Parash","family":"Pokharel","sequence":"additional","affiliation":[{"name":"Geisinger Health Danville Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Salvatore J.","family":"Savona","sequence":"additional","affiliation":[{"name":"Ohio State University Columbus Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4817-6614","authenticated-orcid":false,"given":"Nishant","family":"Verma","sequence":"additional","affiliation":[{"name":"Northwestern University Chicago Illinois USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kevin","family":"Watt","sequence":"additional","affiliation":[{"name":"Data Coordinating Center, Department of Pediatrics University of Utah Health Sciences Center Salt Lake City Utah USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8003-7254","authenticated-orcid":false,"given":"Suneet","family":"Mittal","sequence":"additional","affiliation":[{"name":"Valley Health System Paramus New Jersey USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,4,9]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2023.08.017"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(99)00275-1"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/jce.15342"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2024.02.046"},{"key":"e_1_2_9_6_1","unstructured":"FDA \u201cOral Sotalol US Package Insert \u201d inFood and Drug Administration 2011."},{"volume-title":"R: A Language and Environment for Statistical Computing [Computer Program]","year":"2024","key":"e_1_2_9_7_1"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1159\/000180580"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8159.2000.tb07044.x"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1053\/euhj.2000.2546"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/psp4.13302"}],"container-title":["Journal of Cardiovascular Electrophysiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jce.16677","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,12]],"date-time":"2025-06-12T12:47:33Z","timestamp":1749732453000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jce.16677"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,9]]},"references-count":10,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,6]]}},"alternative-id":["10.1111\/jce.16677"],"URL":"https:\/\/doi.org\/10.1111\/jce.16677","archive":["Portico"],"relation":{},"ISSN":["1045-3873","1540-8167"],"issn-type":[{"type":"print","value":"1045-3873"},{"type":"electronic","value":"1540-8167"}],"subject":[],"published":{"date-parts":[[2025,4,9]]},"assertion":[{"value":"2025-02-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-26","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-04-09","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}