{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T08:04:20Z","timestamp":1783065860023,"version":"3.54.6"},"reference-count":40,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,6,3]],"date-time":"2025-06-03T00:00:00Z","timestamp":1748908800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,6,3]],"date-time":"2025-06-03T00:00:00Z","timestamp":1748908800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Radiofrequency (RF) ablation of premature ventricular complexes (PVCs) is a well\u2010established treatment for patients high PVCs burden, even when arising from epicardial\/intramural localization. Consistent data about safety of using high power RF is lacking in the literature in these regions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>The aim of this study is to investigate the safety of different RF power settings, efficacy and outcome of non\u2010endocardial PVCs ablation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Consecutive patients who underwent PVC ablation were included (2017\u20132023). We defined \u201cNon\u2010Endocardial Radiofrequency Ablation\u201d(NERA) a procedure in which at least one ablation site has been identified into the CVS, aortic cusps, inter\u2010leaflet region or pulmonary cusps.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Total number of NERA sites was 64 in 56 procedures. In 63% of the procedures, high power (\u2265\u200940\u2009W) and in 60% long duration (\u2265\u200960\u2009s) RF was delivered in at least one site (median power: 40\u2009W(30\u201340), median duration of single RF 54\u2009s(45\u201391). In 21% of the procedures, a combination of both high power and long duration RF applications was performed. Overall procedural success was achieved in 46 procedures 82%), complete in 39 (70%), partial in 7 (12%). Only one severe complication (pericardial bleeding) was observed. Multisite ablation was associated with procedural failure. During follow\u2010up, median PVC burden was 0.5%(0.5\u20139.5), with a median reduction of 97%. Multisite ablation and coronary venous system RF were predictors of recurrence (HR 3.6;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.03) and HR 3.85;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.02).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Ablation from non\u2010endocardial sites is a safe and effective procedure, even using high power and\/or long duration RF with clear benefit in terms of PVC burden reduction.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jce.16716","type":"journal-article","created":{"date-parts":[[2025,6,3]],"date-time":"2025-06-03T03:09:25Z","timestamp":1748920165000},"page":"3126-3135","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Non\u2010Endocardial Radiofrequency Ablation of Premature Ventricular Complexes (NERA\u2010PVC): Safety, Efficacy and Outcome"],"prefix":"10.1111","volume":"36","author":[{"given":"Pasquale Valerio","family":"Falzone","sequence":"first","affiliation":[{"name":"Institut Clinic Cardiovascular, Hospital Cl\u00ednic Universitat de Barcelona Barcelona Catalonia Spain"},{"name":"Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS) Barcelona Catalonia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Vazquez\u2010Calvo","sequence":"additional","affiliation":[{"name":"Institut Clinic Cardiovascular, Hospital Cl\u00ednic Universitat de 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