{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T02:40:12Z","timestamp":1792291212987,"version":"4.4.0"},"reference-count":30,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2025,5,23]],"date-time":"2025-05-23T00:00:00Z","timestamp":1747958400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,5,23]],"date-time":"2025-05-23T00:00:00Z","timestamp":1747958400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Obesity is an important risk factor associated with atrial fibrillation (AF). The impact of glucagon\u2010like peptide\u20101 receptor agonists (GLP\u20101 RAs) on recurrent AF among patients undergoing catheter ablation is not well described.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study aimed to evaluate the effect of GLP\u20101 RA on the recurrence of AF among obese patients after catheter ablation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Utilizing the TriNetX research network, we identified patients aged over 18 with obesity (BMI\u2009\u2265\u200930) who underwent AF ablation from January 1, 2015, to December 1, 2022, using Current Procedural Terminology codes. Patients were categorized based on their baseline GLP\u20101 RA use. Through propensity\u2010score matching, each cohort comprised 1558 patients. The primary outcome encompassed a composite of cardioversion, initiation of new antiarrhythmic drug (AAD) therapy, or redo AF ablation. Additional outcomes during the 12\u2010month follow\u2010up included AF readmission, heart failure readmissions, readmissions due to ischemic stroke, and mortality, with a separate analysis done for patients with BMI\u2009&gt;\u200940.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      GLP\u20101 RA use in patients with obesity undergoing AF ablation was linked to a significantly reduced risk of cardioversion, new AAD therapy, and the need for redo AF ablation (hazard ratio [HR] 0.72 [0.65\u20130.80];\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). At 12 months, individuals on GLP\u20101 agonists exhibited a lower likelihood of mortality (HR 0.61 [0.40\u20130.93];\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Although all other secondary outcomes were lower in the GLP\u20101 RA group, there was no significant difference in ischemic stroke between the groups. These results were consistent among patients with BMI\u2009&gt;\u200940, although apart from ischemic stroke, there was no difference in mortality between the two groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The utilization of GLP\u20101 RA in individuals with obesity is linked to a decreased likelihood of arrhythmia recurrence following AF ablation, leading to a reduced requirement for cardioversion, AAD therapy, or redo AF ablation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jce.16737","type":"journal-article","created":{"date-parts":[[2025,5,23]],"date-time":"2025-05-23T06:26:31Z","timestamp":1747981591000},"page":"1808-1816","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Long\u2010Term Impact of GLP\u20101 Receptor Agonists on AF Recurrence After Ablation in Obese Patients"],"prefix":"10.1111","volume":"36","author":[{"given":"Harsh","family":"Patel","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Medicine Southern Illinois University School of Medicine Springfield Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3041-5525","authenticated-orcid":false,"given":"Aakash","family":"Sheth","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine University of Pittsburgh Medical Center Harrisburg Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-5017-6592","authenticated-orcid":false,"given":"Ambica","family":"Nair","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Ocean University Medical Center Brick New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0961-3132","authenticated-orcid":false,"given":"Bhavin","family":"Patel","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Saint Joseph Mercy\u2010Oakland Pontiac Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samarth","family":"Thakkar","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Houston Methodist Debakey Heart and Vascular Center Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bharat","family":"Narasimhan","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Houston Methodist Debakey Heart and Vascular Center Houston Texas 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