{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T11:16:30Z","timestamp":1788174990256,"version":"build-2803163510"},"reference-count":36,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T00:00:00Z","timestamp":1748304000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T00:00:00Z","timestamp":1748304000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Rhythm control with catheter ablation has been established in the management of atrial fibrillation (AF), but the recurrence of AF remains significant. Several studies have demonstrated the benefits of repeat catheter ablation in patients with recurrent AF. However, the optimal timing for repeat ablation to minimize adverse atrial remodeling following recurrence has not been adequately investigated. In this study, we aimed to determine if an optimal timing for repeat catheter ablation existed in patients with recurrent AF.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>We retrospectively screened 1131 patients receiving AF ablation at Taipei Veterans General Hospital and enrolled patients with paroxysmal AF undergoing repeat ablation procedures. Finally, 65 patients were enrolled for further analysis and patients are separated into two groups according to analysis of receiver operating characteristic (ROC) curve of recurrence to repeat ablation time (RAT).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Result<\/jats:title>\n                    <jats:p>\n                      After analysis, the optimal RAT was 222 days, around 7.5 months, with a sensitivity of 56% and a specificity of 78% for 2nd recurrence. KM survival curve also demonstrated Group 2 (RAT\u2009\u2265\u2009222) had higher recurrence of atrial arrhythmias after 2nd ablation (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.01). In multivariable analysis, RAT was shown to be an independent predictor of long\u2010term outcome in patient with AF.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our study suggests that early repeat ablation might be advantageous in managing AF, extending arrhythmia\u2010free intervals, and potentially preventing progression to more persistent arrhythmic forms. Given AF's progressive nature, these results advocate for early intervention strategies aimed at minimizing adverse atrial remodeling and enhancing quality of life for patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jce.16742","type":"journal-article","created":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T05:55:31Z","timestamp":1748325331000},"page":"1849-1857","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Impact of Recurrence\u2010to\u2010Repeat Ablation Time on Long\u2010Term Efficacy and Safety of Patients With Paroxysmal Atrial Fibrillation: Time Matters"],"prefix":"10.1111","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-1475-154X","authenticated-orcid":false,"given":"Yuen Hoong","family":"Phang","sequence":"first","affiliation":[{"name":"Department of Medicine, Heart Rhythm Center, Division of Cardiology Taipei Veterans General Hospital Taipei Taiwan"},{"name":"Division of Cardiology Hospital Sultanah Bahiyah Alor Setar Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2612-0057","authenticated-orcid":false,"given":"Ting\u2010Yung","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Medicine, Heart Rhythm Center, Division of Cardiology Taipei Veterans General Hospital Taipei Taiwan"},{"name":"School of Medicine National Yang Ming Chiao Tung University Taipei Taiwan"},{"name":"Institute of Clinical Medicine and Cardiovascular Research Institute National Yang\u2010Ming Chiao Tung University Taipei Taiwan"},{"name":"National Taipei University of Nursing and Health Sciences Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0545-2156","authenticated-orcid":false,"given":"Shih\u2010Lin","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Medicine, Heart Rhythm Center, Division of Cardiology Taipei Veterans General Hospital Taipei Taiwan"},{"name":"School of Medicine National Yang Ming Chiao Tung University Taipei Taiwan"},{"name":"Institute of Clinical Medicine and Cardiovascular Research Institute National Yang\u2010Ming Chiao Tung University Taipei Taiwan"},{"name":"Department of Experimental Examination, Healthcare and Services Center Taipei Veterans General Hospital Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8395-1052","authenticated-orcid":false,"given":"Yenn\u2010Jiang","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Medicine, Heart Rhythm Center, Division of Cardiology Taipei Veterans General Hospital Taipei Taiwan"},{"name":"School of Medicine National Yang Ming Chiao Tung University Taipei Taiwan"},{"name":"Institute of Clinical Medicine and Cardiovascular Research Institute National Yang\u2010Ming Chiao Tung University Taipei 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