{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T00:29:13Z","timestamp":1779064153979,"version":"3.51.4"},"reference-count":22,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2025,6,16]],"date-time":"2025-06-16T00:00:00Z","timestamp":1750032000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,6,16]],"date-time":"2025-06-16T00:00:00Z","timestamp":1750032000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100004374","name":"Medtronic","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004374","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Creation of a pocket and implant of a cardiac implantable electronic device (CIED) elicits a foreign body response in the presence of the normal wound healing process. An absorbable antibacterial envelope (TYRX\u2122, Medtronic Inc.) was developed to stabilize CIEDs and reduce infections. However, characterization of its impact on pocket healing is limited. We aimed to characterize histological and morphometric features of device capsules in patients previously implanted with an absorbable TYRX.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The TYRX Pocket Health Study (NCT05356546) was a prospective, observational study conducted from June 2022 to July 2023 at 9 sites. The study evaluated characteristics in existing CIED pockets of patients previously implanted with an absorbable TYRX returning for device replacement. Tissue sections were obtained, stained, and evaluated for adhesions, capsule thickness, inflammation, neovascularization, and calcification and compared to a historical control.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The mean time between procedures was 6.8 years. TYRX pockets had significantly decreased adhesions (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05) with no clinically significant calcification. TYRX capsules contained predominantly Type I collagen and were significantly thinner (0.33\u2009\u00b1\u20090.16\u2009mm TYRX, 0.8\u2009\u00b1\u20090.3\u2009mm controls,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.0001). TYRX pockets had low inflammation with 96% of TYRX pockets (26\/27) having absent to mild inflammation.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In this prospective evaluation of long\u2010term pocket healing with an absorbable TYRX, reduced adhesions, low inflammation, and well\u2010formed capsules were observed with no clinically significant calcification. This suggests that TYRX may promote creation of a well\u2010healed pocket desirable for subsequent procedures.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jce.16766","type":"journal-article","created":{"date-parts":[[2025,6,16]],"date-time":"2025-06-16T07:22:01Z","timestamp":1750058521000},"page":"1978-1986","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["An Absorbable Antibacterial Envelope Promotes Development of a Healthy Device Pocket: Results of the TYRX Pocket Health Study"],"prefix":"10.1111","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2012-0486","authenticated-orcid":false,"given":"Francois","family":"Philippon","sequence":"first","affiliation":[{"name":"Institut Universitaire de Cardiologie et de Pneumologie de Qu\u00e9bec Qu\u00e9bec City Quebec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena","family":"Ladich","sequence":"additional","affiliation":[{"name":"CVPath Institute Gaithersburg Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renu","family":"Virmani","sequence":"additional","affiliation":[{"name":"CVPath Institute Gaithersburg Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3461-505X","authenticated-orcid":false,"given":"James E.","family":"Ip","sequence":"additional","affiliation":[{"name":"Weill Cornell Medicine, New York Presbyterian Hospital New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jay","family":"Wright","sequence":"additional","affiliation":[{"name":"Liverpool Heart and Chest Hospital Liverpool UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Andrew Hazlitt","sequence":"additional","affiliation":[{"name":"Clearwater Cardiovascular Consultants Clearwater Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8003-7254","authenticated-orcid":false,"given":"Suneet","family":"Mittal","sequence":"additional","affiliation":[{"name":"Valley Health System Paramus New Jersey USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4590-8584","authenticated-orcid":false,"given":"Mauro","family":"Biffi","sequence":"additional","affiliation":[{"name":"Policlinico Sant Orsola Malpighi Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric","family":"Johnson","sequence":"additional","affiliation":[{"name":"The Stern Cardiovascular Foundation Germantown Tennessee USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Ihrke","sequence":"additional","affiliation":[{"name":"Medtronic Inc. Mounds View Minnesota USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeff","family":"Lande","sequence":"additional","affiliation":[{"name":"Medtronic Inc. Mounds View Minnesota USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aloke V.","family":"Finn","sequence":"additional","affiliation":[{"name":"CVPath Institute Gaithersburg Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chiara","family":"Baldovini","sequence":"additional","affiliation":[{"name":"Pathology Unit, IRCCS Azienda Ospedaliero\u2010Universitaria di Bologna Bologna Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7102-5190","authenticated-orcid":false,"given":"Kiah","family":"Butler","sequence":"additional","affiliation":[{"name":"Medtronic Inc. Mounds View Minnesota USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pauline J.","family":"Beckmann","sequence":"additional","affiliation":[{"name":"Medtronic Inc. Mounds View Minnesota USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7333-5720","authenticated-orcid":false,"given":"Christopher R.","family":"Ellis","sequence":"additional","affiliation":[{"name":"Vanderbilt University Medical Center Nashville Tennessee USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,6,16]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.5603\/FM.a2017.0048"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.smim.2007.11.004"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.2277"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2021.622524"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/pace.12184"},{"issue":"11","key":"e_1_2_10_7_1","article-title":"Device Pocket Scar Predicts Transvenous Lead Extraction Difficulty","volume":"6","author":"MA B and WH Cardiovascular Division, Boston","year":"2015","journal-title":"Journal of Innovations in Cardiac Rhythm Management"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2011.04.033"},{"issue":"8","key":"e_1_2_10_9_1","first-page":"1013","article-title":"Recurrent Implantable Cardioverter\u2010Defibrillator Replacement is Associated With an Increasing Risk of Pocket\u2010Related Complications","volume":"33","author":"Borleffs C. 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