{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T02:42:37Z","timestamp":1782960157829,"version":"3.54.5"},"reference-count":22,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2025,7,9]],"date-time":"2025-07-09T00:00:00Z","timestamp":1752019200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,7,9]],"date-time":"2025-07-09T00:00:00Z","timestamp":1752019200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The incidence and predictors of pacing\u2010induced cardiomyopathy (PICM) in patients undergoing attempted left bundle branch area pacing (LBBAP) are unknown.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To examine the incidence and predictors of PICM in patients with preserved left ventricular ejection fraction (LVEF) and atrioventricular block (AVB) undergoing attempted LBBAP.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The study cohort included consecutive patients undergoing an attempt at LBBAP at the Cleveland Clinic from 2018 until 2022 with preserved LVEF and AVB. PICM was defined as post\u2010PM LVEF decrease to &lt;\u200950% and &gt;\u20095%, &gt;\u200910% decrease from pre\u2010PM implantation. Patients who had alternative reasons for a decrease in LVEF during follow\u2010up were excluded. LBBAP was defined as meeting common criteria for LBBAP and the incidence of PICM was evaluated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 173 patients were included. PICM developed in 13\/173 (7.5%) of patients at 26 (IQR 7\u201370) weeks after PM implantation. In total, 12 (6.9%) patients experienced LVEF\u2009&gt;\u200910% decrease. Of 173 patients, 118 (68.2%) patients met criteria for LBBAP. The LBBAP group had a significantly lower incidence of PICM compared with the non\u2010LBBAP group (log rank\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.048). The optimal V6RWPT for predicting PICM was 80\u2009ms and the incidence of PICM increased in proportion to the increase in V6RWPT. In multivariate analysis, non\u2010LBBA capture (HR: 5.58, 95% CI: 1.46\u201324.32;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.01) and LVEF at pre\u2010PM implant per 10% (HR: 0.11, 95% CI: 0.02\u20130.40;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.0003) were independent predictors for the development of PICM.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The incidence of PICM with LBBAP in paced patients undergoing PM implant with AVB and preserved LVEF is low. LBBA capture was associated with freedom from PICM.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jce.16767","type":"journal-article","created":{"date-parts":[[2025,7,9]],"date-time":"2025-07-09T11:55:57Z","timestamp":1752062157000},"page":"1987-1995","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Incidence and Predictors of Pacing\u2010Induced Cardiomyopathy in Paced Patients Undergoing Attempted Left Bundle Branch Area Pacing"],"prefix":"10.1111","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7269-9808","authenticated-orcid":false,"given":"Katsuhide","family":"Hayashi","sequence":"first","affiliation":[{"name":"Cardiac Electrophysiology and Pacing Section, Department of Cardiovascular Medicine Cleveland Clinic Cleveland Ohio USA"},{"name":"Department of Heart Rhythm Management University of Occupational and Environmental Health, Japan Kitakyushu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3685-3318","authenticated-orcid":false,"given":"Aritra","family":"Paul","sequence":"additional","affiliation":[{"name":"Cardiac Electrophysiology and Pacing Section, Department of Cardiovascular Medicine Cleveland Clinic Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6415-3880","authenticated-orcid":false,"given":"Roy","family":"Chung","sequence":"additional","affiliation":[{"name":"Cardiac Electrophysiology and Pacing Section, Department of Cardiovascular Medicine Cleveland Clinic Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4495-3845","authenticated-orcid":false,"given":"Shady","family":"Nakhla","sequence":"additional","affiliation":[{"name":"Cardiac Electrophysiology and Pacing Section, Department of Cardiovascular Medicine Cleveland Clinic Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chadi","family":"Tabaja","sequence":"additional","affiliation":[{"name":"Cardiac Electrophysiology and Pacing Section, Department of Cardiovascular Medicine Cleveland Clinic Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David O.","family":"Martin","sequence":"additional","affiliation":[{"name":"Cardiac Electrophysiology and Pacing Section, Department of Cardiovascular Medicine Cleveland Clinic Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5281-7598","authenticated-orcid":false,"given":"Thomas","family":"Callahan","sequence":"additional","affiliation":[{"name":"Cardiac Electrophysiology and Pacing Section, Department of Cardiovascular Medicine Cleveland Clinic Cleveland Ohio 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