{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T13:44:43Z","timestamp":1792158283694,"version":"4.4.0"},"reference-count":15,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,7,9]],"date-time":"2025-07-09T00:00:00Z","timestamp":1752019200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>The anterior interventricular vein (AIV) is an important and recognized source of ventricular arrhythmias (VAs) within the coronary venous system. However, no studies have specifically investigated the electrocardiographic (ECG) characteristics and ablation strategies for VAs originating from the AIV.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>This study aimed to investigate the ECG characteristics and optimal ablation strategies for VAs originating from the AIV.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This study comprised 51 patients with VAs originating from AIV.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The 51 patients were divided into proximal (40 cases) and non\u2010proximal groups (11 cases) based on their target sites in AIV. Successful ablation was achieved in 82.5% (33\/40) patients in the p\u2010AIV group and 72.7% (8\/11) patients in the np\u2010AIV group. By ECG analysis, we found a deeper <jats:italic>S<\/jats:italic>\u2010wave in lead I and a lower <jats:italic>R<\/jats:italic>\u2010wave in lead V1 and V2, indicating a more distal origin in AIV. <jats:italic>R<\/jats:italic><jats:sub>I<\/jats:sub>\/<jats:italic>S<\/jats:italic><jats:sub>I<\/jats:sub>\u2009&lt;\u20090.10, <jats:italic>R<\/jats:italic><jats:sub>V2<\/jats:sub>\u2009&lt;\u20090.325\u2009mV, and <jats:italic>R<\/jats:italic><jats:sub>V2<\/jats:sub>\/<jats:italic>S<\/jats:italic><jats:sub>V2<\/jats:sub>\u2009&lt;\u20090.20 were excellent differential indices for predicting VAs originating from the np\u2010AIV, with the predictive value of 91.3%, 95.1%, and 95.8%, respectively. Ablation modalities, including conventional radiofrequency catheter ablation (RFCA) and guidewire ablation, have been applied in AIV VAs. Among successful cases, 87.8% of VAs were ablated by conventional RFCA and 12.2% by guidewire ablation. In the situation of an acute angle between the AIV and distal great cardiac vein (DGCV) or a thin AIV lumen, guidewire ablation should be prioritized over RFCA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>There were significant differences in the ECG characteristics of VAs at different portions of AIV. Guidewire ablation could be considered an alternative approach for treating AIV\u2010originated VAs inaccessible to conventional ablation catheters.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jce.16785","type":"journal-article","created":{"date-parts":[[2025,7,9]],"date-time":"2025-07-09T15:35:27Z","timestamp":1752075327000},"page":"2205-2216","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Ventricular Arrhythmias Originating From Different Portions of the Anterior Interventricular Vein: Electrocardiographic Characteristics and Ablation Strategy"],"prefix":"10.1111","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0906-8485","authenticated-orcid":false,"given":"Zhi\u2010Wei","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Cardiology The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University Wenzhou 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Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University Wenzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jayaseelan Ranichandra","family":"Gokuljayanth","sequence":"additional","affiliation":[{"name":"Department of Cardiology The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University Wenzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1748-7794","authenticated-orcid":false,"given":"Jia\u2010Feng","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Cardiology The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University Wenzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6100-6671","authenticated-orcid":false,"given":"Cheng","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Cardiology The Second 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