{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T19:46:35Z","timestamp":1778355995653,"version":"3.51.4"},"reference-count":25,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,7,9]],"date-time":"2025-07-09T00:00:00Z","timestamp":1752019200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The rapid evolution of cardiac implantable electronic devices (CIEDs) has increased remote transmission data, leading to excessive non\u2010actionable alerts (NAA) and alert fatigue.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>Optimize alert parameters to minimize NAA and evaluate the impact on clinical outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We included 536 participants (mean age 75 (15) years, 60.4% male, 83.4% white) with CIEDs. In 413 patients, CIEDs were reprogrammed to censor alerts as follows: atrial fibrillation (AF) episodes &lt;\u20095.5\u2009h, persistent AF\u2009&gt;\u20091 month with prior alerts, AF\u2009&lt;\u200924\u2009h on anticoagulation or with prior appendage occlusion, and non\u2010sustained ventricular tachycardia (NSVT) in defibrillator platforms. NAAs were tracked 90\u2010days pre\u2010 and post\u2010reprogramming. Incident ischemic stroke and sudden cardiac death (SCD) were assessed over a median 1.8\u2010year follow\u2010up. Logistic regression models examined associations between reprogramming and outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Reprogramming was implemented for AF alerts (69.5%, <jats:italic>n<\/jats:italic>\u2009=\u2009287) and NSVT alerts (30.5%, <jats:italic>n<\/jats:italic>\u2009=\u2009126). After reprogramming, NAAs significantly decreased from 6.68 (SD\u2009=\u200910.02) to 2.27 (SD\u2009=\u20094.58), <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001. During follow\u2010up, ischemic stroke rates in AF patients were similar between reprogrammed (5.2%, <jats:italic>n<\/jats:italic>\u2009=\u200915) and control groups (5.4%, <jats:italic>n<\/jats:italic>\u2009=\u20095). In those with NSVT alerts, SCD incidence was lower in reprogrammed (2.3%, <jats:italic>n<\/jats:italic>\u2009=\u20093) versus controls (9.3%, <jats:italic>n<\/jats:italic>\u2009=\u20093). In logistic regression models adjusted for demographics, CHA\u2082DS\u2082VASC score, anticoagulation status, and prior stroke history, there was no statistically significant difference in stroke risk between groups (OR 0.82 [0.27\u20132.51]).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Guideline\u2010based alert parameters in CIED patients significantly reduced NAA burden with no increasing in adverse outcomes in patients with device\u2010detected AF or NSVT alerts. This approach may reduce noise and safely improve efficiency.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jce.16789","type":"journal-article","created":{"date-parts":[[2025,7,9]],"date-time":"2025-07-09T15:38:54Z","timestamp":1752075534000},"page":"2226-2232","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Exploring Optimal Cardiac Electronic Implantable Devices Programming: Reducing Non\u2010Actionable Alerts and Assessing Clinical Outcomes"],"prefix":"10.1111","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1651-8424","authenticated-orcid":false,"given":"Mohamed A.","family":"Mostafa","sequence":"first","affiliation":[{"name":"Department of Cardiology Wake Forest School of Medicine Winston Salem North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George","family":"Bodziock","sequence":"additional","affiliation":[{"name":"Department of Cardiology Wake Forest School of Medicine Winston Salem North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lindsey","family":"Cotten","sequence":"additional","affiliation":[{"name":"CV Remote Solutions Greensboro North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher L.","family":"Schaich","sequence":"additional","affiliation":[{"name":"Department of Surgery, Hypertension and Vascular Research Center Wake Forest University School of Medicine Winston\u2010Salem North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amber","family":"Seiler","sequence":"additional","affiliation":[{"name":"CV Remote Solutions Greensboro North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Dillon","sequence":"additional","affiliation":[{"name":"Department of Cardiology Wake Forest School of Medicine Winston Salem North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan","family":"Brock","sequence":"additional","affiliation":[{"name":"Department of Cardiology Wake Forest School of Medicine Winston Salem North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ross","family":"Hansen","sequence":"additional","affiliation":[{"name":"Department of Cardiology Wake Forest School of Medicine Winston Salem North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick","family":"Kozak","sequence":"additional","affiliation":[{"name":"Department of Cardiology Wake Forest School of Medicine Winston Salem North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tony","family":"Simmons","sequence":"additional","affiliation":[{"name":"Department of Cardiology Wake Forest School of Medicine Winston Salem North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natalie","family":"Bradford","sequence":"additional","affiliation":[{"name":"Department of Cardiology Wake Forest School of Medicine Winston Salem North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James","family":"Allred","sequence":"additional","affiliation":[{"name":"CV Remote Solutions Greensboro North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick","family":"Whalen","sequence":"additional","affiliation":[{"name":"Department of Cardiology Wake Forest School of Medicine Winston Salem North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0664-7828","authenticated-orcid":false,"given":"Prashant D.","family":"Bhave","sequence":"additional","affiliation":[{"name":"Department of Cardiology Wake Forest School of Medicine Winston Salem North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,7,9]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2015.05.008"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.110.937409"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2010.12.012"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)61176-4"},{"key":"e_1_2_9_6_1","article-title":"2023 HRS\/EHRA\/APHRS\/LAHRS Expert Consensus Statement on Practical Management of the Remote Device Clinic","volume":"25","author":"Ferrick A. 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