{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,18]],"date-time":"2025-09-18T22:56:44Z","timestamp":1758236204789,"version":"3.44.0"},"reference-count":15,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,7,10]],"date-time":"2025-07-10T00:00:00Z","timestamp":1752105600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Wolff\u2013Parkinson\u2013White (WPW) syndrome is a disorder characterized by presence of an accessory pathway (AP) which predisposes patients to tachyarrhythmia and sudden death. The aim of this study was to evaluate the prevalence of high\u2010risk electrophysiologic AP features among WPW patients referred for electrophysiological study (EPS) and to explore whether the AP location can predict the high\u2010risk nature of the AP.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This descriptive observational study was carried out on 70 patients with WPW subjected to invasive EPS. All patients were subjected to determination of AP anterograde conduction properties [AP effective refractory period (APERP) and shortest pre\u2010excited RR interval (SPERRI)], mapping for localization, and ablation attempts of the AP.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty\u2010five patients (35.7%) had an AP antegrade refractory period (APERP)\u2009\u2264\u2009240\u2009ms. The shortest RR interval during pre\u2010excited AF (SPERRI) was \u2264\u2009250\u2009ms in 17 patients. Thirty\u2010two APs (45.7%) were classified as high\u2010risk AP (having APERP\u2009\u2264\u2009240\u2009ms and\/or SPERRI\u2009\u2264\u2009250\u2009ms). Radiofrequency ablation was successful in 59\/63 patients (93.7%). The mean APERP was significantly lower in postero\u2010septal than anteroseptal and mid\u2010septal APs (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.003), and in left sided than right sided APs (<jats:italic>p<\/jats:italic> value\u2009=\u20090.001). Left non\u2010septal APs (specially the left lateral APs) were significantly associated with the presence of high\u2010risk than low\u2010risk parameters. Septal APs (anterior, mid, and posterior) were significantly associated with the presence of low\u2010risk than high\u2010risk parameters.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>High\u2010risk AP features as determined by the antegrade conduction properties are common among WPW patients. AP location may hold significance in predicting the presence of those high\u2010risk electrophysiologic features.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jce.70008","type":"journal-article","created":{"date-parts":[[2025,7,11]],"date-time":"2025-07-11T05:03:17Z","timestamp":1752210197000},"page":"2264-2270","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Accessory Pathway Antegrade Electrophysiologic Features Among Wolff\u2013Parkinson\u2013White Patients: The Risk in Relation to the Location"],"prefix":"10.1111","volume":"36","author":[{"given":"Salah","family":"Atta","sequence":"first","affiliation":[{"name":"Department of Cardiology, Faculty of Medicine Assiut University Assiut Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8196-8878","authenticated-orcid":false,"given":"Mohamed","family":"Aboelhassan","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Faculty of Medicine Assiut University Assiut Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed Khairy","family":"Ibraheem","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Faculty of Medicine Assiut University Assiut Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Salma","family":"Taha","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Faculty of Medicine Assiut University Assiut Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,7,10]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8167.1998.tb00861.x"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199106063242301"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.eurheartj.a060500"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.84.4.1644"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/eux269"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.114.011154"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.116.005207"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8159.1987.tb04511.x"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.56.2.260"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2008.09.037"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.113.000930"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.108.827550"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.111.065722"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacep.2017.10.009"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(92)90022-F"}],"container-title":["Journal of Cardiovascular Electrophysiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jce.70008","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,18]],"date-time":"2025-09-18T13:40:51Z","timestamp":1758202851000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jce.70008"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,10]]},"references-count":15,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2025,9]]}},"alternative-id":["10.1111\/jce.70008"],"URL":"https:\/\/doi.org\/10.1111\/jce.70008","archive":["Portico"],"relation":{},"ISSN":["1045-3873","1540-8167"],"issn-type":[{"type":"print","value":"1045-3873"},{"type":"electronic","value":"1540-8167"}],"subject":[],"published":{"date-parts":[[2025,7,10]]},"assertion":[{"value":"2025-03-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-06-30","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-10","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}