{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T14:08:25Z","timestamp":1783087705386,"version":"3.54.6"},"reference-count":46,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,7,11]],"date-time":"2025-07-11T00:00:00Z","timestamp":1752192000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Differences in baseline characteristics and clinical outcomes exist between female and male patients with atrial fibrillation (AF).<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To assess sex\u2010specific symptoms within 1 month of AF catheter ablation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients undergoing AF ablation between 2000 and 2024 were identified from 57 healthcare organizations using a global federated research network. Female and male patients were 1:1 propensity score matched (PSM) based on baseline characteristics. Symptoms within a month of ablation were identified using ICD\u201010 codes and classified into major systems: cardiac (chest pain, palpitations), respiratory (dyspnea, cough), gastrointestinal (nausea, vomiting, heartburn, dysphagia, bloating, diarrhea, constipation, anorexia), neurological (headache, visual disturbance, speech disturbance, dizziness) and urological (urinary retention and dysuria).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>After PSM, 69\u2009244 patients were included (34\u2009622 in each group). Female patients had a higher incidence of cardiac (female, 8.9% vs. male, 6.1%; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), respiratory (7.9% vs. 6.1%; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), gastrointestinal (3.4% vs. 2.2%; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) and neurological symptoms (3.1% vs. 2.5%; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) compared with male patients. Urological symptoms were more common in male patients (1.6% vs. 0.9%; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) due to a higher incidence of urinary retention (1.1% vs. 0.3%; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). All individual symptom components of cardiac, respiratory, gastrointestinal and neurological composites were more common in female patients, except from heartburn (0.1% vs. 0.1%; <jats:italic>p<\/jats:italic>\u2009=\u20090.49), bloating (0.2% vs. 0.2%; <jats:italic>p<\/jats:italic>\u2009&gt;\u20090.99), anorexia (0.1% vs. 0.1%; <jats:italic>p<\/jats:italic>\u2009=\u20090.79), and speech disturbance (0.2% vs. 0.2%; <jats:italic>p<\/jats:italic>\u2009=\u20090.51) which were similar between sexes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Compared with male patients, female patients experience higher rates of cardiac, respiratory, gastrointestinal, and neurological symptoms within 1 month of AF ablation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jce.70009","type":"journal-article","created":{"date-parts":[[2025,7,11]],"date-time":"2025-07-11T11:14:19Z","timestamp":1752232459000},"page":"2271-2278","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Sex\u2010Based Differences in Symptomatology in the First Month Following Atrial Fibrillation Catheter Ablation"],"prefix":"10.1111","volume":"36","author":[{"given":"Mark T.","family":"Mills","sequence":"first","affiliation":[{"name":"Department of Cardiology Liverpool Heart and Chest Hospital Liverpool UK"},{"name":"Liverpool Centre for Cardiovascular Science at University of Liverpool Liverpool John Moores University and Liverpool Heart and Chest Hospital Liverpool UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory Y. 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