{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T18:13:28Z","timestamp":1787508808779,"version":"build-2736575974"},"reference-count":17,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T00:00:00Z","timestamp":1753833600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>The mechanisms underlying recurrent atrial fibrillation (AF) despite durable pulmonary vein isolation (PVI) in patients with paroxysmal AF (PAF) remain unclear. This study investigates whether left atrial (LA) slow\u2010conduction channels act as a substrate for recurrence following durable PVI.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>High\u2010density LA mapping was performed in 120 PAF patients. LA conduction velocities were calculated using the Local Velocity Vector algorithm. Channels were defined as narrow regions with slow conduction (&lt;\u20090.5\u2009m\/s) and fragmented electrograms. All patients underwent PVI using radiofrequency energy. One\u2010year freedom from recurrent AF was compared based on baseline LA channel presence. A control group of five patients with atrioventricular reentrant tachycardia was included.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 120 patients, 42 (35%) had 54 LA channels identified. Channels represented ~1% of total LA surface area, exhibited slow conduction (~0.23\u2009m\/s), were bordered by lines of block, displayed abnormal electrograms, and demonstrated decremental conduction, suggesting a potential role in reentry. Half were in low\u2010voltage areas while the remainder were in regions with preserved voltage. At 1 year, 3 of 78 patients without channels (4%) had PAF recurrence, all due to PV reconnections, compared to 7 of 42 patients with channels (17%) who experienced recurrence (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.02), 6 of whom had durably isolated PVs on repeat study. No channels were identified in controls.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The absence of LA channels may indicate a PAF phenotype with high PVI success. Conversely, patients with channels are less likely to respond to PVI. It remains unclear whether channels serve as risk indicators or targets for ablation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jce.70023","type":"journal-article","created":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T08:30:12Z","timestamp":1753864212000},"page":"2397-2409","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Left Atrial Slow\u2010Conduction Channels Predict Pulmonary Vein Isolation Outcomes in Paroxysmal Atrial Fibrillation"],"prefix":"10.1111","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9568-2806","authenticated-orcid":false,"given":"Agust\u00edn","family":"Bortone","sequence":"first","affiliation":[{"name":"Service de Cardiologie, H\u00f4pital Priv\u00e9 Les Franciscaines, ELSAN N\u00eemes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4350-1652","authenticated-orcid":false,"given":"F. Daniel","family":"Ramirez","sequence":"additional","affiliation":[{"name":"Division of Cardiology University of Ottawa Heart Institute Ottawa Canada"},{"name":"School of Epidemiology and Public Health University of Ottawa Ottawa Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eloi","family":"Marijon","sequence":"additional","affiliation":[{"name":"D\u00e9partement de Cardiologie H\u00f4pital Europ\u00e9en Georges Pompidou Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5132-692X","authenticated-orcid":false,"given":"Francesco","family":"Montereggi","sequence":"additional","affiliation":[{"name":"Service de Cardiologie, H\u00f4pital Priv\u00e9 Les Franciscaines, ELSAN N\u00eemes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1600-3137","authenticated-orcid":false,"given":"Luca Rosario","family":"Limite","sequence":"additional","affiliation":[{"name":"Service de Cardiologie, Clinique Saint Pierre, ELSAN Perpignan France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,7,30]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.121.010663"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10840-023-01630-9"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000151289.73085.36"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.122.011354"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.121.009899"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/euad310"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacep.2022.01.019"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/pace.14490"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2024.09.017"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/jce.13797"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2021.08.001"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardiores.2003.11.035"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.115.003648"},{"key":"e_1_2_9_15_1","article-title":"Chronobiological Analysis of Electrical Storm at a Single Tertiary Care Center","volume":"6","author":"Incognito C.","year":"2024","journal-title":"Circulation: Arrhythmia and Electrophysiology"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/jce.16193"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2024.04.063"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1056\/EVIDoa2200141"}],"container-title":["Journal of Cardiovascular Electrophysiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jce.70023","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,18]],"date-time":"2025-09-18T13:40:06Z","timestamp":1758202806000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jce.70023"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,30]]},"references-count":17,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2025,9]]}},"alternative-id":["10.1111\/jce.70023"],"URL":"https:\/\/doi.org\/10.1111\/jce.70023","archive":["Portico"],"relation":{},"ISSN":["1045-3873","1540-8167"],"issn-type":[{"value":"1045-3873","type":"print"},{"value":"1540-8167","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,30]]},"assertion":[{"value":"2025-05-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-13","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-30","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}