{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T09:32:58Z","timestamp":1790415178547,"version":"4.1.0"},"reference-count":35,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,8,6]],"date-time":"2025-08-06T00:00:00Z","timestamp":1754438400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,8,6]],"date-time":"2025-08-06T00:00:00Z","timestamp":1754438400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Catheter ablation is a major treatment for atrial fibrillation (AF), but its outcomes in relation to age and frailty are not well understood, especially in an aging population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A retrospective analysis of the 2016\u20132021 National Inpatient Sample database identified patients undergoing catheter ablation for AF. Patients were categorized by age and frailty status (low, intermediate, high). Multivariable logistic regression and propensity score matching were used to examine outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among 292,395 patients, 79.2% were aged 35\u201365 years, 15.7% were aged 66\u201379 years, and 5.1% were aged \u2265\u200980 years at the time of ablation. The proportion of patients aged \u2265\u200980 years increased from 11% in 2016% to 21.1% in 2021. Females comprised a higher proportion of the oldest age group (51.4%), but no sex differences were observed across frailty levels. In\u2010hospital mortality was highest in the high frailty group. Patients over 80 years had higher odds of cardiac rhythm restoration and pacemaker implantation but lower risks of cardiogenic shock, mechanical circulatory support, heart failure, myocardial infarction, and major adverse cardiac and cerebrovascular events (MACCE). Higher frailty was associated with an increased risk of in\u2010hospital mortality, complications, and MACCE.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Catheter ablation is increasingly performed in older patients. Advanced age and higher frailty are independently associated with adverse outcomes. These factors should be considered when evaluating patients for this procedure, and strategies to mitigate these risks should be explored.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jce.70032","type":"journal-article","created":{"date-parts":[[2025,8,6]],"date-time":"2025-08-06T11:45:53Z","timestamp":1754480753000},"page":"2509-2518","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Age, Frailty, and Outcomes After Atrial Fibrillation Ablation: A Nationwide Cohort Study"],"prefix":"10.1111","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6314-2071","authenticated-orcid":false,"given":"Olayiwola","family":"Bolaji","sequence":"first","affiliation":[{"name":"Rutgers University New Jersey Medical School Newark New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olanrewaju","family":"Adabale","sequence":"additional","affiliation":[{"name":"ECU Health Medical Center Greenville North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasemin","family":"Bahar","sequence":"additional","affiliation":[{"name":"Wayne State University Detroit Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Blanche","family":"Echari","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine The Brooklyn Hospital Center Brooklyn New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-2784-4878","authenticated-orcid":false,"given":"Vishnu","family":"Shenoy","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine The Brooklyn Hospital Center Brooklyn New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaskomal","family":"Phagoora","sequence":"additional","affiliation":[{"name":"Touro College of Osteopathic Medicine Harlem New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdul Rasheed","family":"Bahar","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Wayne State University\/Detroit Medical Center Detroit Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7874-4566","authenticated-orcid":false,"given":"M.","family":"Chadi Alraies","sequence":"additional","affiliation":[{"name":"Cardiovascular Institute, Detroit Medical Center, DMC Heart Hospital Detroit Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hakeem","family":"Ayinde","sequence":"additional","affiliation":[{"name":"Department of Cardiology University of North Carolina Chapel Hill North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John N.","family":"Catanzaro","sequence":"additional","affiliation":[{"name":"Division of Electrophysiology ECU Health Medical Center Greenville North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,8,6]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/1747493019897870"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.120.316340"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.113.005119"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/ehjqcco\/qcaa061"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2020.00003"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2019.0693"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2029980"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10840-024-01755-5"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehac544.459"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cger.2010.08.009"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.archger.2007.10.007"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2023.1295108"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/joa3.12580"},{"key":"e_1_2_8_15_1","unstructured":"Healthcare Cost and Utilization Project (HCUP). 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