{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T04:53:04Z","timestamp":1773031984505,"version":"3.50.1"},"reference-count":27,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,7,31]],"date-time":"2025-07-31T00:00:00Z","timestamp":1753920000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,7,31]],"date-time":"2025-07-31T00:00:00Z","timestamp":1753920000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Ventricular arrhythmias (VAs) are common in patients with left ventricular assist devices (LVADs), but their prognostic impact remains uncertain. Prior studies have yielded conflicting results regarding their association with mortality and morbidity. We aimed to evaluate the incidence and clinical outcomes associated with VAs in a large, multicenter LVAD cohort.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We analyzed 408 patients who underwent LVAD implantation across five centers between 2007 and 2015. VA was defined as sustained VAs lasting &gt;\u200930\u2009s or requiring ICD therapy. The effects of pre\u2010 and post\u2010LVAD VA on clinical outcomes\u2014including survival, hospitalizations, and ICD shocks\u2014were assessed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of 408 patients, 254 (62%) had a history of pre\u2010LVAD VA. Compared to those without prior VA, patients with pre\u2010LVAD VA were more likely to be male (85% vs. 75%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.02), receive amiodarone (44% vs. 31%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.01), and have larger left ventricular end\u2010diastolic dimension (LVEDD) (7.1 vs. 6.8\u2009cm,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.01). Postimplant, the pre\u2010VA group had a significantly higher incidence of VA (73% vs. 37%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.0001), atrial arrhythmias (63% vs. 42%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.0001), ICD shocks (41% vs. 32%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.001), and cardiac hospitalizations (median 0.20 vs. 0.08 events\/year,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.0003). However, Kaplan\u2013Meier survival analysis showed no significant difference in overall mortality (log\u2010rank\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.10). On multivariate Cox regression, pre\u2010LVAD VA predicted post\u2010LVAD VA, but LVEDD was the only independent predictor of mortality.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In this multicenter cohort, pre\u2010LVAD VAs were strongly associated with postimplant arrhythmic burden and increased morbidity, but not with long\u2010term mortality. These findings highlight the importance of structural factors such as LVEDD over arrhythmia history in survival outcomes and underscore the need for individualized arrhythmia surveillance and management strategies in LVAD recipients with prior VAs.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jce.70033","type":"journal-article","created":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T05:35:15Z","timestamp":1754026515000},"page":"2478-2484","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Incidence, Predictors, and Outcomes With Ventricular Arrhythmias in Continuous Flow Left Ventricular Assist Device Recipients: A Multicenter Analysis"],"prefix":"10.1111","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4715-0279","authenticated-orcid":false,"given":"Jobin","family":"Varghese","sequence":"first","affiliation":[{"name":"MercyOne North Iowa Medical Center Mason City Iowa USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jashan","family":"Gill","sequence":"additional","affiliation":[{"name":"MercyOne North Iowa Medical Center Mason City Iowa USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rezwan","family":"Munshi","sequence":"additional","affiliation":[{"name":"MercyOne North Iowa Medical Center Mason City Iowa USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8011-0829","authenticated-orcid":false,"given":"Henri","family":"Roukoz","sequence":"additional","affiliation":[{"name":"University of Minnesota Minneapolis Minnesota USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaimin R.","family":"Trivedi","sequence":"additional","affiliation":[{"name":"University of Louisville Louisville Kentucky USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adarsh","family":"Bhan","sequence":"additional","affiliation":[{"name":"Advocate Christ Medical Center Oak Lawn Illinois USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ashwin","family":"Ravichandran","sequence":"additional","affiliation":[{"name":"St. Vincent Hospital Indianapolis Indiana USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer","family":"Cowger","sequence":"additional","affiliation":[{"name":"St. Vincent Hospital Indianapolis Indiana USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chirag","family":"Sandesara","sequence":"additional","affiliation":[{"name":"Inova Heart and Vascular Institute Fairfax Virginia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rahul","family":"Dhawan","sequence":"additional","affiliation":[{"name":"University of Louisville Louisville Kentucky USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rajakrishnan","family":"Vijayakrishnan","sequence":"additional","affiliation":[{"name":"University of Louisville Louisville Kentucky USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark S.","family":"Slaughter","sequence":"additional","affiliation":[{"name":"University of Louisville Louisville Kentucky USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mustafa M.","family":"Ahmed","sequence":"additional","affiliation":[{"name":"University of Florida Gainesville Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4611-3687","authenticated-orcid":false,"given":"Rakesh","family":"Gopinathannair","sequence":"additional","affiliation":[{"name":"Kansas City Heart Rhythm Institute Kansas City Missouri 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