{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T12:26:28Z","timestamp":1789043188866,"version":"build-2803163510"},"reference-count":26,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,8,7]],"date-time":"2025-08-07T00:00:00Z","timestamp":1754524800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,8,7]],"date-time":"2025-08-07T00:00:00Z","timestamp":1754524800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Intermittent ventricular pre\u2010excitation has long been considered a low\u2010risk marker for sudden death. Accessory pathways (APs) with high\u2010risk intermittent antegrade conductive properties may exist, but this still represents a gray area in current guidelines. We evaluated differences in risk characteristics between symptomatic and asymptomatic patients with intermittent pre\u2010excitation (IPX) and those with persistent pre\u2010excitation (PPX) in a multicenter international registry.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>392 consecutive patients [IPX: 79 (20.15%); PPX: 313 (79.85%)] underwent electrophysiological (EP) study. Data on arrhythmia inducibility (AVRT\/AF), AP antegrade conduction properties (ERP\/SPERRI), site, and number were collected.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>No significant differences were found in demographic characteristics and EP features between PPX and IPX patients, including antegrade conductive properties, prevalence of multiple APs, and AP locations, except for AVRT inducibility which was more frequent in IPX group. Similarly, no differences were detected between symptomatic and asymptomatic IPX patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Except for AVRT inducibility, our study shows no significant differences in demographic and other electrophysiological features between PPX and IPX patients. Likewise, no differences in demographic and EP features were detected between symptomatic and asymptomatic IPX patients. Therefore, intermittent pre\u2010excitation is an unreliable noninvasive marker of arrhythmic risk and it warrants an invasive risk assessment via EP study.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jce.70035","type":"journal-article","created":{"date-parts":[[2025,8,8]],"date-time":"2025-08-08T04:29:04Z","timestamp":1754627344000},"page":"2818-2826","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Intermittent Ventricular Pre\u2010Excitation: Clinical Features and Electrophysiological Properties"],"prefix":"10.1111","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2150-3788","authenticated-orcid":false,"given":"Antonio Gianluca","family":"Robles","sequence":"first","affiliation":[{"name":"Cardiology Department L. Bonomo Hospital Andria Italy"},{"name":"Department of Clinical Medicine, Public Health, Life and Environmental Science University of L'Aquila L'Aquila Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9262-6654","authenticated-orcid":false,"given":"Zefferino","family":"Palam\u00e0","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine, Public Health, Life and Environmental Science University of L'Aquila L'Aquila Italy"},{"name":"Villa Verde C.D.C. Health Centre Taranto Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9909-6513","authenticated-orcid":false,"given":"Francesco","family":"Santoro","sequence":"additional","affiliation":[{"name":"Cardiothoracic Department Cardiology Unit, Policlinico Riuniti Foggia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Rauber","sequence":"additional","affiliation":[{"name":"Cardiology Department University Medical Centre Ljubljana Ljubljana Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bor","family":"Antoli\u010d","sequence":"additional","affiliation":[{"name":"Cardiology Department University Medical Centre Ljubljana Ljubljana Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Domenico","family":"Gianfrancesco","sequence":"additional","affiliation":[{"name":"Cardiology Department L. Bonomo Hospital Andria Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Bartolomucci","sequence":"additional","affiliation":[{"name":"Cardiology Department L. Bonomo Hospital Andria Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2961-2783","authenticated-orcid":false,"given":"Pierluigi","family":"Pellegrino","sequence":"additional","affiliation":[{"name":"Cardiothoracic Department Cardiology Unit, Policlinico Riuniti Foggia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simona","family":"Alfieri","sequence":"additional","affiliation":[{"name":"Cardiothoracic Department Cardiology Unit, Policlinico Riuniti Foggia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessio","family":"Borelli","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine, Public Health, Life and Environmental Science University of L'Aquila L'Aquila Italy"},{"name":"Casa di Cura Di Lorenzo Avezzano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Scar\u00e0","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine, Public Health, Life and Environmental Science University of L'Aquila L'Aquila Italy"},{"name":"Casa di Cura Di Lorenzo Avezzano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriele De Masi De","family":"Luca","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine, Public Health, Life and Environmental Science University of L'Aquila L'Aquila Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ermenegildo","family":"de Ruvo","sequence":"additional","affiliation":[{"name":"Polyclinic Casilino Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonardo","family":"Cal\u00f2","sequence":"additional","affiliation":[{"name":"Polyclinic Casilino Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matev\u017e","family":"Jan","sequence":"additional","affiliation":[{"name":"Cardiovascular Surgery Department University Medical Centre Ljubljana Ljubljana Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrej","family":"Pernat","sequence":"additional","affiliation":[{"name":"Cardiology Department University Medical Centre Ljubljana Ljubljana Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvio","family":"Romano","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine, Public Health, Life and Environmental Science University of L'Aquila L'Aquila Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luigi","family":"Sciarra","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine, Public Health, Life and Environmental Science University of L'Aquila L'Aquila Italy"},{"name":"Casa di Cura Di Lorenzo Avezzano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,8,7]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehz467"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics14030296"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/anec.12464"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.98.5.1279"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8159.1990.tb06865.x"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.eurheartj.a059860"},{"issue":"14","key":"e_1_2_10_8_1","first-page":"e506","article-title":"2015 ACC\/AHA\/HRS Guideline for the Management of Adult Patients With Supraventricular Tachycardia: A Report of the American College of Cardiology\/American Heart Association Task Force on Clinical Practice Guidelines and the Heart Rhythm Society","volume":"133","author":"Page R. 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